Gender differences in the effect of fish oil on appetite, inflammation and nutritional status in haemodialysis patients

Zabel, Rachel; Ash, Susan; King, Neil; Näslund, Erik; Bauer, Judy

doi:10.1111/j.1365-277x.2010.01064.x

Cited by 14 publications

(4 citation statements)

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“…Although the FA compositions are typical and specific to each biological specimen, changes in FA profile in response to dietary manipulation have been demonstrated in intervention trials [ 10 ]. Studies in dialysis patients have shown that supplementation of marine n -3 PUFA resulted in incorporation of n -3 PUFA in total plasma [ 33 , 35 , 75 ], TAG [ 36 ], PL [ 66 , 74 ], and erythrocytes [ 32 , 75 ]. Apart from being a biomarker of dietary intake, circulating FAs also have major physiological roles.…”

Section: Discussionmentioning

confidence: 99%

Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review

et al. 2018

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Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA status of DP from different countries, (ii) compare blood FA composition between healthy controls and DP, and (iii) evaluate FA profile and clinical endpoints in DP. Fifty-three articles from 1980 onwards, reporting FA profile in hemodialysis and peritoneal DP, were identified from PubMed, Embase, and the Cochrane library. Studies on pediatric, predialysis chronic kidney disease, acute kidney injury, and transplant patients were excluded. Moderate to high levels of n-3 polyunsaturated fatty acids (PUFA) were reported in Japan, Korea, Denmark, and Sweden. Compared to healthy adults, DP had lower proportions of n-3 and n-6 PUFA, but higher proportion of monounsaturated fatty acids. Two studies reported inverse associations between n-3 PUFAs and risks of sudden cardiac death, while one reported eicosapentaenoic acid + docosahexaenoic acid)/arachidonic acid ratio was inversely associated with cardiovascular events. The relationship between all-cause mortality and blood FA composition in DP remained inconclusive. The current evidence highlights a critical role for essential FA in nutritional management of DP.

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Section: Discussionmentioning

confidence: 99%

Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review

et al. 2018

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“…EPA and DHA have often been used to assess compliance to fish and fish oil intake in intervention studies [175–179], and have been extensively associated with self-reported fish intake, measured either through 24-h dietary recalls or FFQs in a wide range of cohort and cross-sectional studies carried out in different populations [45, 180–183]. Furthermore, EPA and DHA have been widely used to validate proposed FFQs for assessment of fish intake [83, 184–187].…”

Section: Resultsmentioning

confidence: 99%

Biomarkers of meat and seafood intake: an extensive literature review

et al. 2019

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Meat, including fish and shellfish, represents a valuable constituent of most balanced diets. Consumption of different types of meat and fish has been associated with both beneficial and adverse health effects. While white meats and fish are generally associated with positive health outcomes, red and especially processed meats have been associated with colorectal cancer and other diseases. The contribution of these foods to the development or prevention of chronic diseases is still not fully elucidated. One of the main problems is the difficulty in properly evaluating meat intake, as the existing self-reporting tools for dietary assessment may be imprecise and therefore affected by systematic and random errors. Dietary biomarkers measured in biological fluids have been proposed as possible objective measurements of the actual intake of specific foods and as a support for classical assessment methods. Good biomarkers for meat intake should reflect total dietary intake of meat, independent of source or processing and should be able to differentiate meat consumption from that of other protein-rich foods; alternatively, meat intake biomarkers should be specific to each of the different meat sources (e.g., red vs. white; fish, bird, or mammal) and/or cooking methods. In this paper, we present a systematic investigation of the scientific literature while providing a comprehensive overview of the possible biomarker(s) for the intake of different types of meat, including fish and shellfish, and processed and heated meats according to published guidelines for biomarker reviews (BFIrev). The most promising biomarkers are further validated for their usefulness for dietary assessment by published validation criteria.

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“…A quasi-experimental study 32 showed that the low dose omega-3 had no effect on CRP in the treatment group, but when patients were stratified for CRP levels and diabetes, the CRP levels decreased in elevated CRP and non-diabetes patients. An exploratory study 33 reported that fish oil affected inflammatory markers differently between men and women, with males maintaining or reducing CRP and IL-6 levels and females increasing levels of inflammatory markers. That may be associated with estrogen.…”

Section: Agreements and Disagreements With Other Studies Or Reviewsmentioning

confidence: 99%

The effect of fish oil on inflammation markers in adult patients undergoing hemodialysis: A meta‐analysis

Zhou

Tang

et al. 2021

Seminars in Dialysis

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Objective: This meta-analysis was to assess the effect of fish oil supplementation on inflammation markers in adult patients receiving hemodialysis.Methods: CENTRAL, EMBASE, MEDLINE databases were searched from inception to 10 April 2020. Two authors independently searched, selected, and screened the literature. The pooled results are represented by WMD or SMD with 95% confidence intervals. Subgroup analysis and meta-regression were used to explore sources of heterogeneity, and sensitivity analysis was used to assess the robustness of the pooled results. Funnel plots were used to assess publication bias.Results: Eleven RCT (randomized control trials) studies were included. The pooled results showed that fish oil supplementation caused a significant reduction of the CRP(C-reactive protein) level (random model: WMD, À3.36, 95%CI: À5.46 to À1.26, P = .002), especially in patients with baseline CRP ≥ 5 mg/L (random model: WMD, À4.43, 95%CI: À6.10 to À2.76, P = .00001, I 2 = 41%). Meta-regression analyses showed that CRP baseline level (CRP < 5 mg/L) was the main source of heterogeneity (P = .036). Sensitive analyses revealed that the result was hardly changed. Fish oil supplementation might not reduce the level of IL-6 (random model: WMD, À2.26, 95%CI: À19.61 to 15.09, P = .80) in four studies or the level of TNF-α (random model: SMD, À2.51, 95%CI: À6.08 to 1.06, P = .17) in three studies.Conclusions: Fish oil supplementation could reduce the level of CRP in hemodialysis patients, especially in patients with CRP ≥ 5 mg/L, but had no effects on IL-6 and TNF-α. | INTRODUCTIONESRD (end stage renal disease) is a common disease with high incidence. In the United States, there were 124,500 cases of ESRD in 2017, with an incidence of 370.2 per million every year. For this disease, 86.9% of new cases preferred hemodialysis, 1 the most common renal replacement therapy (RRT). Chronic inflammation is a common complication in MHD (maitenance hemodialysis) patients, which can lead to multiple complications, such as malnutrition, erythropoietin resistance, anemia, atherosclerosis, and cardiovascular events, as well as susceptibility to infection. The common inflammatory markers include CRP, IL-6, and TNF-α. Inflammatory markers are significantly associated with cardiovascular events in the general population and MHD patients. [2][3][4][5] The anti-inflammatory therapy can lower the levels of inflammatory markers and reduce cardiovascular events.The ω-3 fatty acids include α-linolenic acid (ALA, C18:3 n-3), eicosapentaenoic acid (EPA, C20:5 n-3), and docosahexaenoic acid (DHA, C22:6 n-3). ALA is short-chain unsaturated fatty acid derived from plants such as linseed, soy, flaxseed, and walnut, which is rarely converted into long-chain unsaturated fatty acid in the body. EPA and DHA are long-chain unsaturated fatty acids derived from fish or fish oil. Fish oil, antiarrhythmic, antithrombotic, and anti-arteriosclerosis, is beneficial in preventing cardiovascular disease, 6 improving

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Gender differences in the effect of fish oil on appetite, inflammation and nutritional status in haemodialysis patients

Cited by 14 publications

References 64 publications

Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review

Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review

Biomarkers of meat and seafood intake: an extensive literature review

The effect of fish oil on inflammation markers in adult patients undergoing hemodialysis: A meta‐analysis

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