Gender Differences in the Clinical Characteristics Among Japanese Patients With Obstructive Sleep Apnea Syndrome

Yukawa, Kumiko; Inoue, Yuichi; Yagyu, Hisanaga; Hasegawa, Tatsuya; Komada, Yoko; Namba, Kazuyoshi; Nagai, Noriko; Nemoto, Shoko; Sano, Erika; Shibusawa, Minoru; Nagano, Naoko; Suzuki, Mamoru

doi:10.1378/chest.08-1414

Cited by 50 publications

(34 citation statements)

References 37 publications

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“…Associations with the metabolic syndrome have been described [6,7], especially in females with severe OSA [7]. Despite the controversy in the development of new onset hypertension in patients with OSA in the Wisconsin Sleep Cohort Study [8] and the Sleep Heart Health Study [9], the association of OSA with hypertension was described in females [8,10,11]. In a recent study, the relative risk of hypertension in subjects with OSA was higher than controls (apnoea/hypopnoea index ,15) and similar in males and females [11].…”

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confidence: 99%

“…Despite the controversy in the development of new onset hypertension in patients with OSA in the Wisconsin Sleep Cohort Study [8] and the Sleep Heart Health Study [9], the association of OSA with hypertension was described in females [8,10,11]. In a recent study, the relative risk of hypertension in subjects with OSA was higher than controls (apnoea/hypopnoea index ,15) and similar in males and females [11]. Another study reported that normotensive females snoring occasionally or regularly have a 29% and 55% increased risk of developing hypertension, respectively, compared with non-snorers [10].…”

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confidence: 99%

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Pregnancy and fetal outcomes of symptoms of sleep-disordered breathing

Bourjeily

Raker²,

Chalhoub³

et al. 2010

European Respiratory Journal

207

230

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The physiological changes of pregnancy may predispose females to develop sleepdisordered breathing (SDB) or protect against it. Studies evaluating outcomes of SDB symptoms in pregnancy are scarce. The goal of this study was to evaluate the prevalence of SDB symptoms in pregnancy and their relationship with pregnancy and neonatal outcomes.A cross-sectional survey of randomly selected immediate postpartum females was performed using the multivariable apnoea prediction index. Record review, including demographics and medical history, was performed. Main outcome measures included pregnancy and neonatal outcomes.1,000 subjects were recruited. Mean¡SD age was 29.1¡6.1 yrs. Factors used in the regression analysis included age, body mass index, diabetes, chronic hypertension, multifetal gestations, smoking and renal disease. Snoring was present in 35.1% of subjects. Symptoms of SDB were associated with a higher likelihood of pregnancy-induced hypertension and pre-eclampsia (adjusted OR 2.3, 95% CI 1.4-4.0), gestational diabetes (adjusted OR 2.1, 95% CI 1.3-3.4) and unplanned Caesarean deliveries (adjusted OR 2.1, 95% CI 1.4-3.2) after multivariable regression analysis. Gasping may have been associated with a higher likelihood of preterm delivery, after adjusting for age and multifetal pregnancies (adjusted OR 1.8, 95% CI 1.1-3.2) but this association appeared to be mediated by pre-eclampsia.Symptoms of SDB are common in pregnancy and associated with a higher likelihood of gestational hypertensive disorders, gestational diabetes and unplanned Caesarean deliveries.

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confidence: 99%

mentioning

confidence: 99%

Pregnancy and fetal outcomes of symptoms of sleep-disordered breathing

Bourjeily

Raker²,

Chalhoub³

et al. 2010

European Respiratory Journal

207

230

View full text Add to dashboard Cite

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“…hypopneas. There are studies (4,6,9,(13)(14)(15)(20)(21)(22)(23)(24) concerning the gender difference in sleep architecture in OSA, but there is no study that emphasizes the difference in apnea/hypopnea component in two genders. Neck circumference and BMI were the most associated with parameters to AHI in males whereas abdominal circumference and BMI were the most associated with parameters to AHI in females in the linear regression analysis.…”

Section: Discussionmentioning

confidence: 99%

Obstrüktif Uyku Apnesinde Apne ve Hipopne İçeriğindeki Cinsiyet Farkı

Yüceege¹,

Fırat²,

Ardıç³

et al. 2014

jtsm

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SummaryIntroduction: We aimed to analyze the apnea and hypopnea structure separately with demographic parameters and sleep architecture in men and women with sleep apnea. Materials and Methods: Patients referred for snoring, witnessed apnea and/or day time sleepiness to Dışkapı Yıldırım Beyazıt Research and Educational Hospital Sleep Center and gone under polysomnography (PSG) between December 2010 and June 2012 were taken in order. PSG reports were analyzed retrospectively. The patients with sleep efficiency less than 40% were excluded. The BMI, neck circumference (NC), abdominal circumference (AC) and PSG values were recorded. Results: Totally 406 patients (250 male, 156 female patients) were studied. NC was found more in males whereas AC and BMI were found significantly more in females. Mean age, apne-hypopnea index (AHI), oxygen desaturation index (ODI) for 3% were similar in two genders. Percentage of total light sleep (Stage 1+2) was significantly more in males while Stage 3 (slow wave sleep: SWS) was more in females. Total apneas were significantly more in males and hypopneas were significantly more in females. The factors associated with AHI were NC and BMI in males and AC and BMI in females. Discussion: We found that, females are more hypopneic and men are more apneic, in a study group of similar apne-hypopnea indexed patients. The different distribution of fat in genders seems to effect the apnea/hypopnea predominance. The clinical significance of the apnea and hypopnea indexes separately can be related with SWS percentage. Prospective studies are needed to evaluate the effect of apneas and hypopneas on morbidity and mortality in both genders. (JTSM 2014;1:16-21)

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Section: Managerial Implicationsmentioning

confidence: 99%

“…Currently there is no questionnaire that targets women for the prediction of obstructive sleep apnoea (Yukawa et al 2009). There have been a number of studies (Chervin 2000;Shepertycky et al 2005;Smith et al 2002;Yukawa et al 2009) showing that women present differently to a clinician with Obstructive Sleep Apnoea. Both the symptoms of depression and obstructive sleep apnoea can be described as sleepiness, fatigue, tiredness and lack of energy, so there is an overlap between these disorders however most clinicians expect extreme daytime sleepiness to be the overriding symptom of obstructive sleep apnoea (Chervin 2000).…”

Section: Managerial Implicationsmentioning

confidence: 99%

Sleep disorder diagnosis: the design and implications of online tools

Blake

Kerr

2014

Decis. Anal.

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Sleep disorders are a significant and growing problem, both for the economy of the nation and for the physical and psychological well-being of individual sufferers. The purpose of this research was to investigate the operational, administrative and medical environment within which sleep physicians currently diagnose patients with sleep disorders and develop an online support system that would more efficiently gather patient history data, and so improve the effectiveness of patient-physician consultations, the diagnoses, and patients' self-management of any subsequent treatment plans. The development of the online tools used a design science approach and those tools evaluated for usefulness and ease of use by physicians and the general population. The physicians found that the patient history information was in a form that facilitated assimilation with the removal of routine data collection allowing a more targeted or shorter consultation. The users found the application easy to use and that it made them think about their sleep quality. The implications for future practice of sleep disorder diagnosis and the value of the collection of patient history which would be available for analysis is also discussed.

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Gender Differences in the Clinical Characteristics Among Japanese Patients With Obstructive Sleep Apnea Syndrome

Cited by 50 publications

References 37 publications

Pregnancy and fetal outcomes of symptoms of sleep-disordered breathing

Pregnancy and fetal outcomes of symptoms of sleep-disordered breathing

Obstrüktif Uyku Apnesinde Apne ve Hipopne İçeriğindeki Cinsiyet Farkı

Sleep disorder diagnosis: the design and implications of online tools

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