Gender differences in the bacteriology of rhinosinusitis

Golan, Yitzhak; Gavriel, Haim; T, Lazarovich; Eviatar, Ephraim

doi:10.1007/s00405-017-4560-5

Cited by 9 publications

(10 citation statements)

References 15 publications

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“…Males may have higher clinical disease measures due to greater incidence of nasal polyps, which has been demonstrated 45 . Sex differences in the microbiome may contribute to differences in symptoms and responsiveness to therapy; Golan et al noted that when compared with females, males undergoing ESS had significantly higher rates of staphylococcal, anaerobic, and polymicrobial growths on sinonasal cultures 46 . At this time, the sinus microbiome has been associated with disease presence and treatment outcome, but its role in disease severity and specific symptom domains is unclear 47 .…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Presentation and Surgical Outcomes From a Prospective Multicenter Chronic Rhinosinusitis Study

Asokan

Mace

Rice

et al. 2022

Otolaryngol.--head neck surg.

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Objective Despite extensive research into chronic rhinosinusitis (CRS) epidemiology, presentation, and outcomes, there is scant knowledge on sex-specific differences. The objective of this study was to identify differences between male and female patients with CRS in baseline disease severity at presentation, choice for surgery vs continued medical treatment, and postoperative response. Study Design We evaluated data on demographic and health characteristics, clinical objective disease measures, and sinus-specific and general health patient-reported outcome measures. Setting Secondary analysis of prospective multicenter outcome study. Methods Comparison of cohort characteristics and baseline and postoperative measures was performed with a t test, chi-square test of independence, or Fisher exact test. Within-subject improvement was compared between sexes with a linear mixed model. Results Females reported worse quality of life on presentation and postsurgery, despite experiencing less severe disease by standard clinical measures. Overall, females and males showed similar within-subject improvement after surgery. However, certain quality of life domains and disease measures showed sex-specific improvement. Females demonstrated greater within-subject improvement in SF6D-derived health utility and the SNOT-22 ear and facial, psychological, and sleep subdomains, although this did not reach statistical significance for the overall cohort. Conclusion Incorporating data on sex-specific differences may be important to personalize CRS treatment decision making. The discordance between patient-reported and clinical measures in CRS has been demonstrated in other pathologies and appears to be exaggerated by sex. Biological and psychological bases for sex-specific differences in CRS manifestations are an intriguing topic for further research.

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Section: Discussionmentioning

confidence: 99%

Sex Differences in Presentation and Surgical Outcomes From a Prospective Multicenter Chronic Rhinosinusitis Study

Asokan

Mace

Rice

et al. 2022

Otolaryngol.--head neck surg.

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“…Although the impact of sex in CRSwNP and AERD is not yet fully elucidated, studies evaluating e.g. the nasal microbiome in patients with CRS suggest differences in microbial colonization in women and men [24]. Furthermore, sex and gender specific differences might differ in CRS phenotypes like CRsNP, CRSwNP patients and patients suffering from AERD.…”

Section: Discussionmentioning

confidence: 99%

Differences in men and women suffering from CRSwNP and AERD in quality of life

Bartosik

Liu

Campion

et al. 2020

Eur Arch Otorhinolaryngol

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Purpose While the overall impact of chronic rhinosinusitis (CRS) on patients’ health is diverse, many affected individuals have a substantially impaired quality of life (QoL). The aim of this study was to evaluate the impact of sex-associated differences specifically in the subgroups of CRS with nasal polyps (CRSwNP) and aspirin-exacerbated respiratory disease (AERD) by assessing QoL parameters in women and men separately. Methods In a retrospective single-center study, 59 patients with CRSwNP (39 males and 20 females) and 46 patients with AERD (18 males and 28 females) were included. Patient-reported outcome measures (PROM) evaluating QoL via the Sino-Nasal Outcome Test-20 German Adapted Version (SNOT-20 GAV) as well as the total polyp score (TPS) were analysed. Results There was no significant difference in TPS (p = 0.5550) and total SNOT-20 GAV scores (p = 0.0726) between male or female patients with CRSwNP or AERD. Furthermore, no significant sex differences were found within disease groups regarding the subcategories of the SNOT-20 GAV items. Conclusion Thus, quality of life is severely impaired in patients suffering from various forms of CRS regardless of their sex.

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“…There are several possible reasons for this. There may be a gender difference in the bacteriology of CRS, as male patients are more likely to have Staphylococcus aureus identified in cultures taken during functional endoscopic sinus surgery (FESS) . Another factor may be the distribution of the inflammatory changes in the sinuses.…”

Section: Discussionmentioning

confidence: 99%

“…16 A subsequent study looking at the most recent NSAS from 2006 showed no significant difference in sinus surgery by gender, 8 whereas data from the SASD of Florida found that men had more procedures per ESS case than women. 9 One conclusion that can be drawn from these 24 Another factor may be the distribution of the inflammatory changes in the sinuses. In a study looking specifically at the gender differences in patients with CRS who elected to proceed with FESS, women were shown to have less-severe findings on preoperative imaging despite having worse preoperative quality of life symptom scores.…”

Section: Discussionmentioning

confidence: 99%