Gender differences in the antioxidant response of oral administration of hydroxytyrosol and oleuropein against N-ethyl-N-nitrosourea (ENU)-induced glioma

Ramírez-Expósito, María Jesús; Carrera-González, María Pilar; Mayas, Marı́a Dolores; Martı́nez-Martos, José Manuel

doi:10.1016/j.foodres.2020.110023

Cited by 11 publications

(9 citation statements)

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“…The restorative effects exhibited by olive extracts are corroborated with Ramírez‐Expósito et al. (2021) who observed treatment with olive polyphenols, that is, oleuropein and hydroxytyrosol preserved the cellular architecture of stressed rat's neural parenchyma. Likewise, Park et al.…”

Section: Discussionsupporting

confidence: 66%

“…inhibition of the inflammatory enzymes, quenching and neutralization of free radicals, antioxidants, and antiinflammatory properties (Angeloni et al., 2017; Rodríguez‐Morató et al., 2015). Furthermore, oleuropein and hydroxytyrosol have shown neuroprotective effects by passing through the blood–brain barrier (BBB) thus contribute to the brain's antioxidant pool and minimize the adverse impact of excessive reactive oxygen and reactive nitrogen species (Ramírez‐Expósito et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke‐induced depressive‐like behaviors in Sprague–Dawley rats

et al. 2021

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Depression is broadly acclaimed as a mental health anomaly and despite advancements in the development of antidepressant drugs, they are linked with side effects. Dietary modifications and medicinal plants like olives can be used as effective strategies due to their antioxidant, immune‐modulatory, antiinflammatory, and anticonvulsant properties. Considering the compositional alterations in olive fruits during ripening, the antidepressant potential of olive fruits at different degrees of ripeness, that is, un‐ripened (green) and ripened (black) was investigated. Rats were randomly divided into five groups: G0 (Normal diet), G1 (Normal diet + smoke exposure (SE), G2 (Normal diet + SE + Citalopram), G3 (Normal diet + SE + Green olive extract), and G4 (Normal diet + SE + Black olive extract). Depressive‐like behaviors were induced in all groups through cigarette smoke exposure except G0. Green and black olive extracts prevented depressive behaviors by reducing the immobility time of rats in forced swim test and tail suspension test while increased the latency to respond in hot plate assay. Moreover, lipid peroxidation in brain tissue was reduced with citalopram, green, and black olive extracts. Additionally, treatments also enhanced the antioxidant pool of brain tissues. Histological examination revealed that olive extracts and citalopram prevented cigarette smoke‐induced moderate to severe necrosis and congestion in the brain parenchyma and elucidated antidepressant potential by improving the expression of monoamine oxidase‐A, solute carrier family 6 member 4, and brain‐derived neurotrophic factor genes. Conclusively, olives may act as a promising antidepressant agent in ameliorating cigarette smoke‐induced depressive‐like behaviors. Practical applications Olive extracts at both ripening stages revealed an antidepressant‐like effect almost similar to the standard antidepressant drug and also prevented oxidative damages. Therefore, from the current findings, it can be recommended that food ingredients with antidepressant potential like olives should be incorporated in future interventions to combat depression/psychiatric anomalies and diet therapy should be encouraged to alleviate lifestyle‐related disorders.

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke‐induced depressive‐like behaviors in Sprague–Dawley rats

et al. 2021

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“…Cancer Seçme et al, 2016;Capo et al, 2017;Sherif, Al-Gayyar, 2018;Ruzzolini e al., 2018;;Nicolin et al, 2019;Torić et al, 2019;Przychodzen et al,2019a;Przychodzen et al, 2019b;Castejón et al, 2020;Leto et al, 2020;Asgharzade et al, 2021;Hamed et al, 2021;Ramírez-Expósito et al, 2021.…”

Section: Cholesterolmentioning

confidence: 99%

Leaves of Olea europaea L. as a source of oleuropein: characteristics and biological aspects

Otero¹,

Lorini

Oliveira

et al. 2021

RSD

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Olive fruits, leaves and derived virgin oils are known to be good sources of polyphenols and other antioxidants that have recently received increasing interest. In addition, its derivatives are responsible for the bitter and spicy taste of green olive fruits and virgin olive oils. In the physiology of the olive plant, the enzymatic biotransformation of oleuropein is related to fruit ripening and the tissue-specific defense mechanism. The oleuropein is one of the main phenolic compounds identified in fruits and olive leaves. It has several pharmacological properties, including antioxidant, cardioprotective, anti-heterogeneous, neuropathic, anti-cancer and other effects. Oleuropein is slightly absorbed after oral administration and reaches a maximum plasma concentration, being widely distributed in various organs and tissues, including the heart, liver and brain. In view of recent studies on the use oleuropein obtained from olive leaves in the treatment and prevention of diseases, this work was carried out with the aim of compiling the main information available in the literature through this review.

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“…Hydroxytyrosol (HT) is a kind of polyphenolic compounds which mainly exist in the fruits and branches of olive oil, and acts as a natural antioxidants. 16 It is reported that HT has various physiological effects, including lipid-lowering, 17 anti-inflammatory, 18 and antitumor, 19 these effects are usually related to their antioxidant capacity. The HT monomer and a number of dimer derivatives have previously been isolated from the B. rynchopetera , 14,20 further chemical constituents provided three new HT dimers, rynchopeterine H ( 1 ), rynchopeterine I ( 2 ) and trans -2-(3,4-dihydroxy-phenyl)-3-hydroxy-7-(2-hydroxyethyl)-1,4-benzdioxane ( 3 ), and another four dimers, trans -2-(3,4-dihydroxy-phenyl)-3-hydroxy-6-(2-hydroxyethyl)-1,4-benzdioxane ( 4 ), trans -2-(3,4-dihydroxyphenyl)-3-acetylamino-7-(N-acetyl-2-aminoethyl)-1,4-benzodioxane( 5 ), trans -2-(3,4-dihydroxyphenyl)-3-acetylamino-7-(2-hydroxyethyl)-1,4-benzodioxane( 6 ), and trans -2-(3,4-dihydroxyphenyl)-3-acetylamino-6-(2-hydroxyethyl)-1,4-benzodioxane( 7 ) (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…10,14 Hydroxytyrosol (HT) is a kind of polyphenolic compounds which mainly exist in the fruits and branches of olive oil, and acts as a natural antioxidants. 16 It is reported that HT has various physiological effects, including lipid-lowering, 17 antiinflammatory, 18 and antitumor, 19 these effects are usually related to their antioxidant capacity. The HT monomer and a number of dimer derivatives have previously been isolated from the B. rynchopetera, 14,20 1).…”

Section: Introductionmentioning

confidence: 99%

Hydroxytyrosol Dimers from Medicinal Insect Blaps Rynchopetera and the in Vitro Cytotoxic Activity

Pang

Wang

et al. 2022

Natural Product Communications

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The edible Blaps rynchopetera Fairmaire is widely used for its various medicinal effects. From its ethyl acetate fraction, three new hydroxytyrosol dimers, rynchopeterine H (1), rynchopeterine I (2) and trans-2-(3,4-dihydroxy-phenyl)-3-hydroxy-7-(2-hydroxyethyl)-1,4-benzdioxane (3), together with four known similar dimers were obtained by chromatography of silica gel and Sephadex LH-20. Their structures were identified by HRESIMS, 1D and 2D NMR spectra analysis. Compounds 1-4 were obtained as a mixture, and cytotoxicity screening for HepG2, Caco-2, U251, AGS, B16 and Bel-7402 cell lines showed that the mixture of compounds 1-4 exhibited significantly selective cytotoxicity and good inhibitory activity on the proliferation of mouse melanoma cells (B16) with an IC50 value of 27.37 μg·mL−1.

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Gender differences in the antioxidant response of oral administration of hydroxytyrosol and oleuropein against N-ethyl-N-nitrosourea (ENU)-induced glioma

Cited by 11 publications

References 82 publications

Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke‐induced depressive‐like behaviors in Sprague–Dawley rats

Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke‐induced depressive‐like behaviors in Sprague–Dawley rats

Leaves of Olea europaea L. as a source of oleuropein: characteristics and biological aspects

Hydroxytyrosol Dimers from Medicinal Insect Blaps Rynchopetera and the in Vitro Cytotoxic Activity

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