Gender differences in temporomandibular disorders in adult populational studies: A systematic review and meta‐analysis

The aim of this systematic review (SR) was to determine the association between temporomandibular disorders (TMDs) and pubertal development. Due to the inadequacy of the conventional PICO (Population, Interventions, Comparisons and Outcome) format used for intervention-based SRs, the Joanna Briggs Institute's guidelines for synthesising evidence related to associations with a focus on aetiology were adopted. A search of the PubMed and LIVIVO databases covering the period from January 1980 to May 2018 yielded four publications, which fulfilled the inclusion criteria. Analysis of articles based on the Pubertal Development Scale showed that TMD prevalence increases with pubertal development. Although no sex difference in TMD prevalence and diagnosis was observed, more females reported TMD anamnestic variables, including accounts of temporomandibular pain during pubertal maturity. The higher prevalence of depression and somatisation during pubertal development may contribute to more TMD symptom reporting in females. More prospective studies incorporating standardised methods for diagnosing TMDs and detecting comorbid psychosocial and somatic problems are desired to further elucidate the relationship between TMDs and pubertal development.

Section: Discussionmentioning

confidence: 77%

Association between temporomandibular disorders and pubertal development: A systematic review

Song

Yap

Türp

2018

“…This observation may also apply in other countries. Yet, it should be borne in mind that the risk of adult females developing TMD is greater than among males . Considering the aforementioned statements and the elevated TMD prevalence during adolescence, there is a high possibility that orthodontists and dentists will encounter patients with pre‐existing TMD who seek therapy for their malocclusion.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of temporomandibular disorders in patients seeking orthodontic treatment: A systematic review

Lai

Yap

Türp

2019

The objective of this systematic review was (a) to establish the prevalence of temporomandibular disorders (TMDs) in patients seeking orthodontic treatment and (b) to determine the association between the presence of TMD and sex, age and malocclusion. A systematic literature search was performed according to PRISMA guidelines from 1969 to 2019 using the PubMed and LIVIVO databases. Eight study articles met the inclusion and exclusion criteria. An additional three contributions were identified through manual searching of the reference lists of retrieved articles.The methodological quality of the 11 articles was assessed with the Joanna Briggs Institute Critical Appraisal Checklist for prevalence studies. TMD prevalence ranged from 21.1% to 73.3%. The frequency of painful TMD signs/symptoms varied from 3.4% to 65.7%, while non-painful signs/symptoms ranged from 3.1% to 40.8%. The percentage of males and females presenting with TMD varied from 10.6% to 68.1% and 21.2 to 72.4%, respectively. In all studies, TMD prevalence was higher among females. The majority of articles reported more TMD signs/symptoms in individuals older than 18 years as compared to younger ones (≤18 years). While in four studies no association between TMD and malocclusion was found, another three investigations indicated that TMD may be related to certain occlusal traits. The TMD prevalence in patients seeking orthodontic treatment was high, with many individuals presenting painful TMD signs/symptoms. Female and older patients appear to have a greater occurrence of TMD. Although no strong association between TMD and malocclusion was established, several occlusal traits were implicated. K E Y W O R D Sage, malocclusion, orthodontics, sex, temporomandibular disorders | 271 LAI et AL.

“…With regard to the prevalence of TMDs, epidemiological data have shown that women are at higher risk than men of developing TMD, as well as of having more inflammation, facial pain and sensitivity in the masticatory muscles and TMJ. The same scenario was observed in the compilation of the data in the present review, where 408 patients were women and 101 were men.…”

Section: Discussionmentioning

confidence: 99%

Association between oxidative stress and temporomandibular joint dysfunction: A narrative review

Braz

Portella

Seehaber

et al. 2020

Background The role of oxidative stress in temporomandibular disorders (TMDs) has been studied using synovial fluid, to evaluate oxidative stress (im)balance and its potential role in the onset and/or progression of the disease. Objective This review aimed to evaluate the association between oxidative stress markers and the etiopathogenesis of TMJ dysfunction by means of synovial fluid analysis. Methods Two independent reviewers searched the electronic databases from inception to March 2019: PubMed/MEDLINE, LILACS, SciELO, EMBASE, TRIPDATABASE, SCOPUS, and Google Scholar. The following key search terms were used: Temporomandibular Joint Disorders OR Temporomandibular Joint Disc OR Temporomandibular Joint Dysfunction Syndrome OR Temporomandibular Joint OR Facial Pain AND Free Radicals OR Oxidative Stress. Data were extracted from the selected articles, including study design, sample profile, TMJ disease reported, diagnostic method, reactive oxygen and nitrogen species evaluated, enzymatic and non‐enzymatic antioxidants evaluated, and techniques used to measure free radicals and antioxidants. Results After title and abstract screening of 6974 results, and full‐text reading, 19 studies were included. All selected articles were cross‐sectional observational studies. Enzymatic and non‐enzymatic antioxidant defences appeared to be reduced in these patients, resulting in the establishment of the oxidative stress process. In addition, the studies showed a positive correlation between the severity of the intra‐articular TMD and the increase in oxidative damage. Conclusion The establishment of oxidative stress, whether by an increase in reactive oxygen/nitrogen species or by a decrease in antioxidant defences, or a combination of both, may be associated with the establishment and maintenance of intra‐articular damage.