2003
DOI: 10.1080/1462220021000060482
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Gender differences in quit rates following smoking cessation with combination nicotine therapy: Influence of baseline smoking behavior

Abstract: Women are less successful than men at quitting smoking. We examined whether the male vs. female cessation outcome was influenced by baseline smoking behavior in participants who attempted to quit by using nicotine inhaler (NI) plus nicotine patch (NP) combination therapy. This double-blind, randomized, placebo-controlled trial enrolled 196 men and 204 women. Group 1 (99 men, 101 women) received NI plus NP (15 mg nicotine/16 h) for 6 weeks, then NI plus placebo patch (PP) for 6 weeks, then NI alone for 14 weeks… Show more

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Cited by 160 publications
(102 citation statements)
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“…FTND is a measure of nicotine dependence that is subjective in nature. In some studies it is indicated that men tend to be more dependent than women, and in some others no difference was reported (Berlin et al, 2003;Bohadana et al, 2003;Targowski, et al, 2004;Gallus et al, 2005;John et al 2005). In this study there was inter-gender difference in terms of mean FTND scores, i.e.…”
Section: Discussionmentioning
confidence: 44%
“…FTND is a measure of nicotine dependence that is subjective in nature. In some studies it is indicated that men tend to be more dependent than women, and in some others no difference was reported (Berlin et al, 2003;Bohadana et al, 2003;Targowski, et al, 2004;Gallus et al, 2005;John et al 2005). In this study there was inter-gender difference in terms of mean FTND scores, i.e.…”
Section: Discussionmentioning
confidence: 44%
“…Data about this issue are mixed, with some studies supporting a gender difference in cessation success [19][20][21][22][23] and others not supporting this finding. [24][25][26] Furthermore, the presence of hardcore smokers, those most likely to have substantial difficulty quitting, may have far-reaching impact on how to best allocate cessation resources.…”
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confidence: 99%
“…27 Rodent studies have also shown that the OPRM1 G allele may play a role in susceptibility to addiction to alcohol, nicotine, heroin and cocaine. [28][29][30][31][32] There is considerable evidence for sex differences in smoking cessation, 33 with men demonstrating higher levels of successful cessation than women, although the evidence that men and women derive differential benefit from NRT remains equivocal. 34 It has been argued that these differences may in part be owing to sex differences in the reinforcing effects of nicotine, 35 and it is notable that there is growing evidence for sex differences in the activity of the opioid pathway.…”
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confidence: 99%