Gender differences in prediabetes and insulin resistance among 1356 obese children in Northern California

Tester, June M.; Sharma, Sushma; Jasik, Carolyn Bradner; Mietus‐Snyder, Michele; Tinajero-Deck, Lydia

doi:10.1016/j.dsx.2013.06.002

Cited by 31 publications

(35 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While insulin levels were higher overall in females, the male patients were more likely to have metabolic abnormalities associated with IR including hypertriglyceridemia (33.3% vs. 18.5%) and impaired fasting glucose (22.2% vs. 8.9%). These results are similar to those reported by Tester et al in a study of pediatric patients in Northern California (19). In this population of predominantly Hispanic obese and overweight children, male patients were more likely to have impaired fasting glucose while female patients were more likely to have elevated HOMA.…”

Section: Discussionsupporting

confidence: 92%

“…Our findings also suggest that there may be gender differences in the progression of these metabolic disturbances that may impact the ability of screening studies to identify children at the greatest risk. In the study by Tester et al, no gender differences were seen in HbA 1c which identified more pre-diabetic patients than fasting glucose measurement (19). Because HbA 1c does not require fasting, it may be a better screening tool than TRG/HDL ratio or insulin and glucose based measures.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Use of the triglyceride to HDL cholesterol ratio for assessing insulin sensitivity in overweight and obese children in rural Appalachia

Bridges

Jarrett

Thorpe

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

Background Studies have suggested that triglyceride to HDL-cholesterol ratio (TRG/HDL) is a surrogate marker of insulin resistance (IR), but information regarding its use in pediatric patients is limited. Objective This study investigated the ability of TRG/HDL ratio to assess IR in obese and overweight children. Subjects The sample consisted of de-identified electronic medical records of patients aged 10–17 years (n = 223). Materials and methods Logistic regression was performed using TRG/HDL ratio as a predictor of hyperinsulinemia or IR defined using homeostasis model assessment score. Results TRG/HDL ratio had limited ability to predict hyperinsulinemia (AUROC 0.71) or IR (AUROC 0.72). Although females had higher insulin levels, male patients were significantly more likely to have hypertriglyceridemia and impaired fasting glucose. Conclusions TRG/HDL ratio was not adequate for predicting IR in this population. Gender differences in the development of obesity-related metabolic abnormalities may impact the choice of screening studies in pediatric patients.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Use of the triglyceride to HDL cholesterol ratio for assessing insulin sensitivity in overweight and obese children in rural Appalachia

Bridges

Jarrett

Thorpe

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…Sex disparities in cardiometabolic risk factors have been described by others (7, 24, 26, 27) although few studies include Hispanic/Latino children in adequate numbers to examine results by sex. A prospective study of cardiometabolic risk factors during adolescence showed an increased risk in males that was independent of adiposity (27).…”

Section: Discussionmentioning

confidence: 99%

“…Another study, based on NHANES data suggested that the impact of obesity on cardiometabolic risk factors was stronger in boys compared with girls (4). A large study of Hispanic/Latino youth in California found that boys were more likely to have impaired fasting glucose, but girls were more insulin resistant (7). It’s interesting to note that the adverse cardiometabolic profile in boys was observed among boys in the normal weight range and not among those with overweight or obesity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sex Differences in Cardiometabolic Risk Factors among Hispanic/Latino Youth

Isasi

Parrinello

Ayala

et al. 2016

The Journal of Pediatrics

View full text Add to dashboard Cite

Objective To determine the prevalence of obesity and cardiometabolic risk in US Hispanic/Latino youth and examine whether there are disparities by sex in cardiometabolic risk factors. Study design SOL Youth is a population-based cross-sectional study of 1466 Hispanic/Latino youth (8-16 years old) who were recruited from four urban US communities (Bronx, NY; Chicago, IL, Miami, FL, and San Diego, CA) in 2012-2014. The majority of children were US-born (78%) and from low-income and immigrant families. Cardiometabolic risk factors were defined using national age- and sex-specific guidelines. Results The prevalence of obesity was 26.5%. The prevalence of class II-III obesity, diabetes and dyslipidemia was high (9.7%, 16.5%, and 23.3%, respectively). The prevalence of cardiometabolic risk factors increased with severity of obesity in both, boys and girls. Boys had a higher prevalence of diabetes and of elevated blood pressure than girls (20.9% vs. 11.8% and 8.5% vs. 3.3%). In multivariable analyses, younger boys were more likely to have obesity class II-III than girls (OR = 3.59; 95% CI 1.44, 8.97). Boys were more likely to have prediabetes than girls (OR = 2.02; 95% CI 1.35, 3.02), and the association was stronger at older ages. Conclusions The prevalence of cardiometabolic risk factors was high in this sample of Hispanic youth. Boys had a more adverse cardiometabolic profile compared with girls that may put them at higher risk of diabetes and cardiovascular disease later in life. Reasons for this disparity and the long-term clinical implications remain to be elucidated.

show abstract

Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity

Bonito¹,

Pacifico

Chiesa

et al. 2016

J Endocrinol Invest

View full text Add to dashboard Cite

show abstract

Gender differences in prediabetes and insulin resistance among 1356 obese children in Northern California

Cited by 31 publications

References 15 publications

Use of the triglyceride to HDL cholesterol ratio for assessing insulin sensitivity in overweight and obese children in rural Appalachia

Use of the triglyceride to HDL cholesterol ratio for assessing insulin sensitivity in overweight and obese children in rural Appalachia

Sex Differences in Cardiometabolic Risk Factors among Hispanic/Latino Youth

Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity

Contact Info

Product

Resources

About