Gender differences in Parkinson's disease depression

Perrin, Andrew J.; Nosova, Ekaterina; Co, Kim Carmela D.; Book, Adam A.; Iu, Oscar; Silva, Vanessa; Thompson, Christina; McKeown, Martin J.; Stoessl, A. Jon; Farrer, Matthew J.; Appel‐Cresswell, Silke

doi:10.1016/j.parkreldis.2016.12.026

Cited by 38 publications

(35 citation statements)

References 11 publications

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“…This aspect is particularly relevant, since depressive symptoms have a great negative impact upon QoL and personality ( 9 , 78 ). In general, women showed more depressive symptoms than men, in line with results from other groups ( 27 , 79 , 80 ). Repeated measures correlations confirmed a direct link between the level of depressive signs in female patients and their individual LEDD at the three stages.…”

Section: Discussionsupporting

confidence: 89%

Sex Disparities in the Self-Evaluation of Subthalamic Deep Brain Stimulation Effects on Mood and Personality in Parkinson's Disease Patients

et al. 2020

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Changes in personality are one of the main concerns Parkinson's disease (PD) patients raise when facing the decision to undergo neurosurgery for deep brain stimulation (DBS) of the subthalamic nucleus (STN). While clinical instruments for monitoring functional changes following DBS surgery are well-established in the daily therapeutic routine, personality issues are far less systematically encompassed. Moreover, while sex disparities in the outcomes of STN-DBS therapy have been reported, little is known about the different effects that DBS treatment may have on mood and personality traits in female and male patients. To this aim, the effect of STN-DBS on personality traits was assessed in 46 PD patients (12 women and 34 men) by means of the Freiburg Personality Inventory. The Becks Depression Inventory (BDI-I) and the Parkinson's Disease Questionnaire were used to evaluate patients' level of depression and quality of life (QoL). Patients completed the questionnaires a few days before, within the first year, and 2 years after surgery. The 12 personality traits defined by the FPI-R questionnaire did not change significantly after STN-DBS surgery ( p = 0.198). Women declared higher depression scores through all study stages ( p = 0.009), but also showed a stronger QoL amelioration after surgery than male patients ( p = 0.022). The BDI-I scores of female patients clearly correlated with their levodopa equivalent daily dose (LEDD; r = 0.621, p = 0.008). Remarkably, in both male and female patients, higher pre-operative LEDDs were related to worse post-operative QoL scores ( p = 0.034). These results mitigate the concerns about systematic personality changes due to STN-DBS treatment in PD patients and encourage an early DBS approach, before severe levodopa-induced sequelae may irreparably compromise the patients' QoL. In the future, more focus should lie on sex-related effects, since female patients seem to profit more than male patients from STN-DBS, in terms of reduced depressive symptoms associated with a reduction of the LEDD and amelioration of QoL. These aspects may help to redress the sex imbalance in PD patients treated with DBS, given that women are still strongly under-represented.

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Section: Discussionsupporting

confidence: 89%

Sex Disparities in the Self-Evaluation of Subthalamic Deep Brain Stimulation Effects on Mood and Personality in Parkinson's Disease Patients

et al. 2020

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“…However, gender differences in motor and non-motor symptoms are not apparent, except for increased incidence of depression in women in one study [62]. It is uncertain how a female-specific depressive profile will impact diagnosis and treatment [63].…”

Section: Limitationsmentioning

confidence: 99%

Subtyping of Parkinson’s Disease - Where Are We Up To?

Qian

Huang

2019

Aging and disease

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Heterogenous clinical presentations of Parkinson's disease have aroused several attempts in its subtyping for the purpose of strategic implementation of treatment in order to maximise therapeutic effects. Apart from a priori classifications based purely on motor features, cluster analysis studies have achieved little success in receiving widespread adoption. A priori classifications demonstrate that their chosen factors, whether it be age or certain motor symptoms, do have an influence on subtypes. However, the cluster analysis approach is able to integrate these factors and other clinical features to produce subtypes. Differences in inclusion criteria from datasets, in variable selection and in methodology between cluster analysis studies have made it difficult to compare the subtypes. This has impeded such subtypes from clinical applications. This review analysed existing subtypes of Parkinson's disease, and suggested that future research should aim to discover subtypes that are robustly replicable across multiple datasets rather than focussing on one dataset at a time. Hopefully, through clinical applicable subtyping of Parkinson's disease would lead to translation of these subtypes into research and clinical use.

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“…Women are more likely than are men to report fatigue, depression, and anxiety, but less likely to report hyposmia or sexual dysfunction. [39][40][41][42][43][44] Feelings of worthlessness, irritability, agitation, self-punishment, loss of pleasure, and self-dislike may differentiate women with PD and depression from those without depression. 39 Women also have a lower risk of developing cognitive impairment.…”

Section: Parkinson's Diseasementioning

confidence: 99%

“…[39][40][41][42][43][44] Feelings of worthlessness, irritability, agitation, self-punishment, loss of pleasure, and self-dislike may differentiate women with PD and depression from those without depression. 39 Women also have a lower risk of developing cognitive impairment. 45,46 Nonetheless, women with PD are more likely than men to utilize long-term care facilities.…”

Section: Parkinson's Diseasementioning

confidence: 99%

Movement Disorders in Women

Baker

Hung

2017

Semin Neurol

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Movement disorders such as Parkinson's disease (PD), restless legs syndrome (RLS), chorea, essential tremor, and Tourette syndrome, occur in men and women of all ages. Yet, considerable sex differences in epidemiology, clinical features, and treatment exist in these disorders. In this review, we highlight key differences in the evaluation and management of women with movement disorders, addressing sex-specific complications of treatment and unique challenges surrounding the management of movement disorders during pregnancy. We review the complex relationship between estrogen and movement disorders, including the putative neuroprotective effects of estrogen in PD and the modulatory effects on RLS and chorea associated with autoimmune disease. Further understanding of sex-specific and hormonal effects on clinical features will be important to optimize the management of women with movement disorders in the future.

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Gender differences in Parkinson's disease depression

Cited by 38 publications

References 11 publications

Sex Disparities in the Self-Evaluation of Subthalamic Deep Brain Stimulation Effects on Mood and Personality in Parkinson's Disease Patients

Sex Disparities in the Self-Evaluation of Subthalamic Deep Brain Stimulation Effects on Mood and Personality in Parkinson's Disease Patients

Subtyping of Parkinson’s Disease - Where Are We Up To?

Movement Disorders in Women

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