Gender Differences in Nonalcoholic Fatty Liver Disease

Mahtab, Mamun Al; Ghosh, Jayanta; Bhatia, Shobna; Nagral, Aabha; Bangar, Manisha; Menezes, Sherna; Butt, Nazish; Manchanayake, Jayani Harshika; Singh, Shivaram Prasad

doi:10.5005/jp-journals-10018-1370

Cited by 20 publications

(19 citation statements)

References 78 publications

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“…It has been observed that sex differences contribute significantly to the prevalence and development of MASLD [ 52 ]. We also found differences between men and women regarding their significant barriers to exercise ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

Barriers to Exercise in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Patient Survey

Deshpande,

Olynyk,

Ayonrinde

et al. 2024

J Clin Med Res

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Background Although adequate physical activity is an essential component of treatment for metabolic dysfunction-associated steatotic liver disease (MASLD), the majority of people with MASLD do not engage in regular exercise and lead sedentary lifestyles. We aimed to identify perceived barriers to exercise and to examine awareness about the role of exercise in the treatment of MASLD. Methods Individuals aged 18 years and above were recruited from a hepatology outpatient clinic. MASLD severity was assessed using controlled attenuation parameter (CAP) and transient elastography (TE) determined liver stiffness measurement (LSM) for the severity of hepatic steatosis and fibrosis, respectively. An online questionnaire was administered to record self-reported exercise patterns, barriers to exercise, and knowledge regarding effectiveness of different types of exercise for MASLD. Results Eighty-one participants (57% female) with a mean age of 55.3 ± 13.4 years and a mean body mass index (BMI) of 33.8 ± 6.4 answered the questionnaire. The mean CAP score was 335.7 ± 47.8 dB/m, and the median LSM was 12.45 kPa. While most patients (83%) considered MASLD to be a serious health concern, 73% did not achieve the recommended exercise levels of ≥ 150 min of moderate-intensity physical activity per week, and 54% were unsure about the role of exercise in the treatment of MASLD. Commonly reported barriers to exercise included physical and mental health issues (57%), lack of time (43%), lack of enjoyment in exercising (31%), fatigue caused by exercise (24%), and others (25%). Conclusions Most participants with MASLD were unaware of the role of exercise as a potential treatment option and were not achieving recommended exercise levels. Inadequate time, physical and mental health problems, lack of enjoyment in exercise, and fatigue were major barriers.

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Section: Discussionmentioning

confidence: 99%

Barriers to Exercise in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Patient Survey

Deshpande,

Olynyk,

Ayonrinde

et al. 2024

J Clin Med Res

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“…Another study from South China reported that the prevalence of NAFLD in the age group under 50 years old was significantly higher in men compared with women (22.4% vs. 7.1%, respectively, p < 0.001). However, this pattern was reversed in the age group of 50 years and older (20.6% vs. 27.6%, respectively, p < 0.05) [ 158 , 160 ].…”

Section: Mechanisms Of the Relationship Between Nafld And Ahmentioning

confidence: 99%

“…Also, it was shown that the frequency of NAFLD in women increases with age to a greater extent than in men, and the maximum differences were recorded in the age group of 70–79 years. On the contrary, the incidence of this pathology in men was similar in all age groups [ 157 , 158 , 159 ]. Another study from South China reported that the prevalence of NAFLD in the age group under 50 years old was significantly higher in men compared with women (22.4% vs. 7.1%, respectively, p < 0.001).…”

Section: Mechanisms Of the Relationship Between Nafld And Ahmentioning

confidence: 99%

“…It has been argued that increased adiposity was due to the presence of an extra X chromosome rather than the absence of a Y chromosome, as shown by genetic studies in mice with XO and XXY chromosomes. The established mechanism involved certain genes avoiding X chromosome inactivation and exhibiting increased levels of expression in the adipose tissue and liver of XX mice rather than XY mice [ 158 , 171 ].…”

Section: Mechanisms Of the Relationship Between Nafld And Ahmentioning

confidence: 99%

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Which Comes First, Nonalcoholic Fatty Liver Disease or Arterial Hypertension?

Golubeva,

Sheptulina,

Elkina

et al. 2023

Biomedicines

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Non-alcoholic fatty liver disease (NAFLD) and arterial hypertension (AH) are widespread noncommunicable diseases in the global population. Since hypertension and NAFLD are diseases associated with metabolic syndrome, they are often comorbid. In fact, many contemporary published studies confirm the association of these diseases with each other, regardless of whether other metabolic factors, such as obesity, dyslipidemia, and type 2 diabetes mellites, are present. This narrative review considers the features of the association between NAFLD and AH, as well as possible pathophysiological mechanisms.

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“…It further contributes to extra-hepatic chronic complications and regulatory pathways [4]. The current gender-based prevalence of NAFLD is approximately 30-40% in men and 15-20% in women [5].…”

Section: Introductionmentioning

confidence: 99%

The Pivotal Role of the Membrane-Bound O-Acyltransferase Domain Containing 7 in Non-Alcoholic Fatty Liver Disease

Chandrasekaran,

Weiskirchen

2023

Livers

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Non-alcoholic fatty liver disease (NAFLD) is a common and prevalent disorder affecting 25 percent of the adults in the United States and 32 percent of adults globally. It is one of the common causes of chronic liver disease characterized by steatosis, which can lead to inflammation, fibrosis, and cirrhosis. NAFLD is strongly associated with obesity and insulin resistance. Multiple genetic variants have been consistently found to be associated with NAFLD; one of them is found in the TMC4-MBOAT7 loci. One variant (rs641738 C>T) within MBOAT7 encoding lysophosphatidyl inositol acyltransferase increases the risk for NAFLD development and triggers hepatic inflammation by regulating arachidonic acid levels. This review provides an overview of the MBOAT7 gene, pathogenesis of NAFLD, understanding the regulation of MBOAT7 and mechanistic link between MBOAT7 and NAFLD. It further summarizes pathophysiologically relevant in vivo and in vitro studies on MBOAT7 and challenges in treating complex NAFLD with recent progress made in the treatment of NAFLD. As such, this review provides useful information on MBOAT7 and NAFLD interrelation, which has the potential of deciphering novel therapeutic targets rather than well-known genetic variants such as PNPLA3 and TM6SF2.

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Gender Differences in Nonalcoholic Fatty Liver Disease

Cited by 20 publications

References 78 publications

Barriers to Exercise in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Patient Survey

Barriers to Exercise in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Patient Survey

Which Comes First, Nonalcoholic Fatty Liver Disease or Arterial Hypertension?

The Pivotal Role of the Membrane-Bound O-Acyltransferase Domain Containing 7 in Non-Alcoholic Fatty Liver Disease

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