Gender differences in LDL- and HDL-cholesterol subfractions in patients after the acute ischemic stroke and their association with oxidative stress markers
Abstract:The aim of our study was to examine gender differences of LDL- and HDL-cholesterol subfractions in patients after the acute ischemic stroke with focus on small LDL and HDL subfractions, and their association with oxidative stress markers. In addition, we have monitored the 7-day effect of cholesterol-lowering drugs administered to patients after the acute ischemic stroke, on these subfractions. Eighty two stroke patients and 81 age matched controls were included in this study. Blood was collected from patients… Show more
“…After 50 years, cholesterol levels in men tend to continue to grow. 22 This is consistent with the study results, although the number of men but the mean cholesterol level of men was higher by a difference of 17.47 mg/dl. Statistically, there was no relationship between gender and cholesterol levels in respondents (p=0.883), supporting previous studies with the results that there was no relationship between sex and cholesterol levels (p=0.847).…”
Section: Effects Of Red Dragon Fruit On Cholesterolsupporting
Background: Nutritional status is closely related to high cholesterol levels. High cholesterol levels as a trigger for other metabolic diseases. Fruits high in fiber and vitamin C can be used to keep blood cholesterol levels regularly.
Aim:To determine the effect of red dragon fruit on blood cholesterol levels in people with excessive nutritional status.
Methods:Research used an experimental approach with a pretest and post-test control group design. The sample consisted of 2 groups, namely the control group and the intervention group, with 50 respondents in each group. The sample was taken using purposive sampling. The intervention group got red dragon fruit juice for seven days. Blood cholesterol levels are measured by laboratory tested using intravenous blood. The statistical test used the Paired T-Test and Independent T-Test.
Results:The difference mean posttest-pretest control group and intervention groups were 13.56 mmHg and -13.06 mmHg. The analysis of pretest-posttest blood cholesterol levels among the control and intervention groups were p=0.514 and p=0.035. The difference between the control group and the intervention group was 0.022.
Conclusion:Red dragon fruit is effective in reducing blood cholesterol levels in people with excessive nutritional status.
“…After 50 years, cholesterol levels in men tend to continue to grow. 22 This is consistent with the study results, although the number of men but the mean cholesterol level of men was higher by a difference of 17.47 mg/dl. Statistically, there was no relationship between gender and cholesterol levels in respondents (p=0.883), supporting previous studies with the results that there was no relationship between sex and cholesterol levels (p=0.847).…”
Section: Effects Of Red Dragon Fruit On Cholesterolsupporting
Background: Nutritional status is closely related to high cholesterol levels. High cholesterol levels as a trigger for other metabolic diseases. Fruits high in fiber and vitamin C can be used to keep blood cholesterol levels regularly.
Aim:To determine the effect of red dragon fruit on blood cholesterol levels in people with excessive nutritional status.
Methods:Research used an experimental approach with a pretest and post-test control group design. The sample consisted of 2 groups, namely the control group and the intervention group, with 50 respondents in each group. The sample was taken using purposive sampling. The intervention group got red dragon fruit juice for seven days. Blood cholesterol levels are measured by laboratory tested using intravenous blood. The statistical test used the Paired T-Test and Independent T-Test.
Results:The difference mean posttest-pretest control group and intervention groups were 13.56 mmHg and -13.06 mmHg. The analysis of pretest-posttest blood cholesterol levels among the control and intervention groups were p=0.514 and p=0.035. The difference between the control group and the intervention group was 0.022.
Conclusion:Red dragon fruit is effective in reducing blood cholesterol levels in people with excessive nutritional status.
“…To interpret these findings, further studies including fecal metabolome analysis should be necessary. However, of the 32 pathways, lipid metabolism seems of note, because Žitňanová et al (17) recently reported that subfractions of plasma lipid were significantly altered in acute phase of stroke, another limitation was that we did not adjust background factors to compare gut microbiota between groups. Previous report showed that several changes in gut microbiota were associated with age and sex, by analyzing 277 healthy individuals.…”
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a major hereditary small vessel disease caused by mutations in NOTCH3. The variations in progression and severity among patients suggest that the CADASIL phenotype is modified by some genetic and environmental factors. Recent studies have shown the potential roles of gut microbiota in human diseases. We hypothesized that gut microbiota modifies the disease phenotype. We performed gut microbial meta 16S rRNA analysis of fecal samples from 15 CADASIL patients and 16 controls. The microbial α and β diversities and taxonomy were compared between CADASIL patients and controls and between CADASIL patients with and without an ischemic stroke history. No signifi cant difference in α or β diversity was observed in either case control or subgroup comparisons. In the taxonomic microbial analysis, there was a significant increase in abundance of 6 genera and significant decrease in 2 genera in CADASIL patients compared with controls. There was a significant decrease in abundance of 2 genera in CADASIL patients with compared with those without stroke. This is the first study on CADASIL focusing on gut micro biota. Our findings suggest that gut microbiota modifies the onset and progression of CADASIL.
“…Notwithstanding that this study of middle-aged and older adults is the largest application of a HDLperox assay to date, and a number of unique findings were generated, there were also limitations. It should be acknowledged that the origins and consequences of gender and race-related differences in physiology and disease are multifactorial [ 34 ]. The current analysis did not consider many lifestyle variables and health care practices that can influence lipid metabolism and function, including diet, smoking, alcohol consumption and physical activity.…”
Background
High-density lipoprotein (HDL) plays a critical role in protection against atherosclerosic and cardiovascular disease (ASCVD). In addition to contributing to clearing excess vascular cholesterol, HDL particles exhibit antioxidative functions, helping to attenuate adverse effects of oxidized low-density lipoproteins. However, these beneficial properties can be undermined by oxidative stress, inflammation, and unhealthy lifestyles and diet, as well as influenced by race and sex. Thus, when assessing cardiovascular risk, it is important to consider multifactorial aspects of HDL, including antioxidant activity rather than just total amount and type of HDL-cholesterol (HDL-C) particles. Because prior research showed HDL peroxide content (HDLperox) can be inversely associated with normal anti-oxidant HDL activity, elevated HDLperox may serve as a bioindicator of HDL dysfunction.
Methods
In this study, data from a large national cohort of Americans was utilized to determine the impact of sex, race, and diabetes status on HDLperox in middle-aged and older adults. A previously developed cell-free fluorometric method was utilized to quantify HDLperox in serum depleted of apo-B containing lipoproteins.
Results
In keeping with predictions, white men and diabetics exhibited HDLperox in the atypical upper range, suggestive of less functional HDL. White men had higher HDLperox levels than African American males (13.46 ± 6.10 vs. 10.88 ± 5.81, p < .001). There was also a significant main effect of type 2 diabetes (F(1,1901) = 14.9, p < .0001). Overall, African Americans evinced lower HDLperox levels, despite more obesity (10.3 ± 4.7 vs.11.81 ± 5.66 for Whites) suggesting that other aspects of lipid metabolism and psychosocial factors account for the higher prevalence of ASCVD in African Americans.
Conclusion
This research helps to provide a more comprehensive understanding of HDL function in a racially and metabolically diverse adult population. HDLperox content was significantly different in adults with type 2 diabetes, and distinctive in nondiabetic White males, and suggests other processes account for the higher prevalence of ASCVD among African Americans.
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