Gender differences in initial symptoms and symptoms at diagnosis in dementia with Lewy bodies

Utsumi, Kumiko; Fukatsu, Reiko; Hara, Yuko

doi:10.1111/psyg.12642

Cited by 2 publications

(4 citation statements)

References 5 publications

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“…In contrast, our analyses on w -scores showed that none of the observed sex differences in network measures in healthy controls were statistically significant in DLB patients. At a first glance, this might seem to be at odds with the previously reported sex differences in many aspects of DLB, ranging from epidemiology to pathogenesis to progression to symptom manifestation 2 – 4 , 9 , 12 , 27 . However, our findings suggest a potentially disease-driven convergence of grey matter networks in women and men with DLB.…”

Section: Discussionmentioning

confidence: 86%

“…Additionally, sex differences have been found regarding core clinical features of DLB and their order of appearance 10 . Whereas men with DLB more often present with REM-sleep behaviour disorder (RBD) and parkinsonism 11 , 12 , visual hallucinations are typically more frequent in women with DLB 12 , 13 . The sex differences in clinical features and their time course, together with a higher likelihood of Alzheimer’s disease co-pathology in women, were previously suggested to cause a delay in women meeting clinical diagnostic criteria for DLB 9 , 10 , 14 , 15 .…”

Section: Introductionmentioning

confidence: 99%

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Grey matter networks in women and men with dementia with Lewy bodies

Habich,

Oltra,

Schwarz

et al. 2024

npj Parkinsons Dis.

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Sex differences permeate many aspects of dementia with Lewy bodies (DLB), yet sex differences in patterns of neurodegeneration in DLB remain largely unexplored. Here, we test whether grey matter networks differ between sexes in DLB and compare these findings to sex differences in healthy controls. In this cross-sectional study, we analysed clinical and neuroimaging data of patients with DLB and cognitively healthy controls matched for age and sex. Grey matter networks were constructed by pairwise correlations between 58 regional volumes after correction for age, intracranial volume, and centre. Network properties were compared between sexes and diagnostic groups. Additional analyses were conducted on w-scored data to identify DLB-specific sex differences. Data from 119 (68.7 ± 8.4 years) men and 45 women (69.9 ± 9.1 years) with DLB, and 164 healthy controls were included in this study. Networks of men had a lower nodal strength compared to women. In comparison to healthy women, the grey matter networks of healthy men showed a higher global efficiency, modularity, and fewer modules. None of the network measures showed significant sex differences in DLB. Comparing DLB patients with healthy controls revealed global differences in women and more local differences in men. Modular analyses showed a more distinct demarcation between cortical and subcortical regions in men compared with women. While topologies of grey matter networks differed between sexes in healthy controls, those sex differences were diluted in DLB patients. These findings suggest a disease-driven convergence of neurodegenerative patterns in women and men with DLB, which may inform precision medicine in DLB.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Grey matter networks in women and men with dementia with Lewy bodies

Habich,

Oltra,

Schwarz

et al. 2024

npj Parkinsons Dis.

View full text Add to dashboard Cite

show abstract

“…In contrast, almost none of the observed of sex differences in global network measures in healthy controls was signi cant in DLB patients. At a rst glance, this might seem to be at odds with the previously reported sex differences in many aspects of DLB, ranging from epidemiology to pathogenesis to progression to symptom manifestation (Perez et al 2010;Fereshtehnejad et al 2013;Savica et al 2013;Kane et al 2018;Fujimi et al 2008;van de Beek et al 2020;Utsumi, Fukatsu, and Hara 2021;Tsunoda et al 2018). However, even though the cross-sectional design of our study does not allow us to observe the effects directly, it marks a potentially disease-driven convergence of female and male grey matter networks in DLB.…”

Section: Discussionmentioning

confidence: 96%

“…Additionally, sex differences have been found regarding core clinical features of DLB. Whereas male DLB patients more often present with REMsleep behavioural disorder (RBD) and parkinsonism (Bayram et al 2021;Utsumi, Fukatsu, and Hara 2021), psychiatric symptoms are more frequent in female DLB patients (Chiu et al 2018;Tsunoda et al 2018;Utsumi, Fukatsu, and Hara 2021) but compare (Bayram et al 2021). Especially hallucinations, both visual and auditory, are more frequent in female DLB patients and the content of the hallucinations also differs between the sexes (Chiu et al 2018;Tsunoda et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Sex differences in grey matter networks in dementia with Lewy bodies

Habich

Oltra

Schwarz

et al. 2023

Preprint

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Objectives Sex differences permeate many aspects of dementia with Lewy bodies (DLB), including epidemiology, pathogenesis, disease progression, and symptom manifestation. However, less is known about potential sex differences in patterns of neurodegeneration in DLB. Here, we test whether grey matter networks also differ between female and male DLB patients. To assess the specificity of these sex differences to DLB, we additionally investigate sex differences in healthy controls (HCs). Methods A total of 119 (68.7 ± 8.4 years) male and 45 female (69.9 ± 9.1 years) DLB patients from three European centres and the Mayo Clinic were included in this study. Additionally, we included 119 male and 45 female age-matched HCs from the Mayo Clinic. Grey matter volumes of 58 cortical, subcortical, cerebellar, and pontine brain regions derived from structural magnetic resonance images were corrected for age, intracranial volume, and centre. Sex-specific grey matter networks for DLB patients and HCs were constructed by correlating each pair of brain regions. Network properties of the correlation matrices were compared between sexes and groups. Additional analyses were conducted on W-scored data to identify DLB-specific findings. Results Networks of male HCs and male DLB patients were characterised by a lower nodal strength compared to their respective female counterparts. In comparison to female HCs, the grey matter networks of male HCs showed a higher global efficiency, modularity, and a lower number of modules. None of the global and nodal network measures showed significant sex differences in DLB. Conclusions The disappearance of sex differences in the structural grey matter networks of DLB patients compared to HCs may indicate a sex-dependent network vulnerability to the alpha-synuclein pathology in DLB. Future studies might investigate whether the differences in structural network measures are associated with differences in cognitive scores and clinical symptoms between the sexes.

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Gender differences in initial symptoms and symptoms at diagnosis in dementia with Lewy bodies

Cited by 2 publications

References 5 publications

Grey matter networks in women and men with dementia with Lewy bodies

Grey matter networks in women and men with dementia with Lewy bodies

Sex differences in grey matter networks in dementia with Lewy bodies

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