Gender Differences in Inflammatory Bowel Disease

Greuter, Thomas; Manser, Christine N.; Pittet, Valérie; Vavricka, Stephan R.; Biedermann, Luc

doi:10.1159/000504701

Cited by 114 publications

(77 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study published in 2020 reports similar results: a lower QoL among women, compared to men diagnosed with IBD [10]. This nding corresponds to data observed in the general population, more precisely a higher rate of absenteeism from work and a more frequent use of health care services among women compared to men [10,11].…”

Section: Discussionsupporting

confidence: 57%

Quality of Life Impact and Special Issues in Women with Inflammatory Bowel Diseases

Constantinescu

Gheorghe

Rinja

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: The impact of inflammatory bowel diseases (IBD) on quality of life (QoL) of patients is significant and has important social and professional consequences. Methods: We aimed to describe the patients’ perspective regarding the impact of IBD on their overall QoL and to evaluate the differences between men and women. An observational cross-sectional study, that included 180 patients with IBD in clinical remission, was conducted. All the patients completed a number of 3 questionnaires in order to evaluate the general aspects of their QoL. A separate questionnaire was created regarding gender-specific issues in women with IBD encounter. Also, particular features such as the incidence of anemia and osteoporosis among IBD patients were documented. The data obtained were analyzed and compared between the two gender-classified groups. Results: According to the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), patients had a general perception of a good QoL, but the impact was higher in women. Fatigue and tiredness were severely perceived almost to the same degree regardless of gender, whereas anxiety and unemployment were more present in men. No significant differences in women with IBD during active disease and during disease remission were found. Conclusions: The overall quality of life of IBD patients is affected in many aspects, leading to the deterioration of their social and professional lives, for both men and women, but some aspects remain gender-specific and require a personalized standard of care.

show abstract

Section: Discussionsupporting

confidence: 57%

Quality of Life Impact and Special Issues in Women with Inflammatory Bowel Diseases

Constantinescu

Gheorghe

Rinja

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Though to date there is no obvious explanation for this difference, it has been suspected that this could be due to genetic, environmental and hormonal differences 3,4 . Notably, in inflammatory bowel disease, it has been suggested that the menstrual cycle specifically impacts disease presentation, course and complications 6 . This finding opens the question and potential to further understand how hormonal differences impact AP presentation and disease course.…”

Section: Discussionmentioning

confidence: 99%

“…Hormonal differences have been seen in PBC, primary sclerosing cholangitis and autoimmune hepatitis, noting that estrogen may play a role in the immune system response 4 . The role of estrogen has proven to be more significant in autoimmune disorders, such as Sjogren's syndrome or PBC, but it is unclear what role it plays in AP 6 . Additional studies to clarify the role of sex biology in AP could help to both triage cases and tailor treatment, as current practices for resuscitation and treatment for AP are uniform for men and women.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sex differences in outcomes of acute pancreatitis: Findings from a nationwide analysis

Sharma

Weissman

Aburayyan

et al. 2021

J Hepato Biliary Pancreat

View full text Add to dashboard Cite

Background Sex is thought to play a significant role in predicting outcomes in numerous diseases. The role sex plays in acute pancreatitis (AP) remains limited. We sought to determine if sex is associated with hospitalization outcomes in this population, using a large national database. Methods This was a retrospective study of adult patients with AP utilizing the 2016 and 2017 National Inpatient Sample via ICD‐10 codes. The clinical courses of females were compared to that of males. The primary outcome was all‐cause inpatient mortality. Secondary outcomes, including healthcare utilization, were assessed. Statistical analyses were performed using STATA, version 16.1. Results Of the 553 480 adult patients hospitalized with AP; 25.3% had AP secondary to alcohol (61.4% male, 38.6% female) and 17.44% secondary to gallstones (48.6% male, 51.4% female). Females were significantly older than males (52.81 years vs 50.97 years, P < .01). Females had a significantly lower likelihood of mortality (aOR: 0.69), shock (aOR: 0.64), sepsis (aOR: 0.70), acute kidney injury (aOR 0.66), intensive care unit admission (aOR 0.53), and pancreatic drainage (aOR 0.61) as compared to males (all with P < .01). There was no significant difference between females and males with regards to mean length of stay and hospitalization charges and costs. Conclusions In this large cohort of patients admitted for AP, despite being significantly older, we found that females had significantly improved clinical outcomes, including lower mortality, compared to males. Further prospective studies are needed to accurately understand these differences to guide clinical practice.

show abstract

“…In human studies, while there are reports of a male predisposition to ulcerative colitis development, these are largely in populations over the age of 45. Our model at 5 weeks in the adult mouse better mimics an earlier onset of disease in humans, where sex‐specific difference in measures of weight loss and colon length are less consistently observed 21,22 . These results provide insights into how the in utero immune environment can influence postnatal susceptibility to disease, and in particular to the development of ulcerative colitis, a condition which has been linked in the past to changes in the maternal environment, but for which there was prior little evidence to support this possibility.…”

Section: Discussionmentioning

confidence: 68%

The role of in utero endotoxin exposure in the development of inflammatory bowel disease in mice

Banfield

Fulton

Burd

et al. 2020

American J Rep Immunol

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD), which is comprised of the clinical subtypes ulcerative colitis and Crohn's disease, is characterized by episodes of excessive inflammation of the gastrointestinal tract. In ulcerative colitis, the inflammation is limited to the colonic mucosa, whereas Crohn's disease is characterized by transmural inflammation that can extend anywhere from the mouth to the anus. 1-3 Although the precise mechanisms leading to IBD remain incompletely understood, current thinking suggests that the disease stems from dysregulation of the mucosal immune response in a genetically susceptible host, in association with ill-defined dietary factors. 1-5 While environmental factors are thought to be important in driving disease development, 6,7 the potential role of the in utero environment on IBD pathogenesis remains largely unexplored. Previous authors have shown that maternal smoking during early pregnancy 8

show abstract

Gender Differences in Inflammatory Bowel Disease

Abstract: a on behalf of Swiss IBDnet, an official working group of the Swiss Society of Gastroenterology

Cited by 114 publications

References 62 publications

Quality of Life Impact and Special Issues in Women with Inflammatory Bowel Diseases

Quality of Life Impact and Special Issues in Women with Inflammatory Bowel Diseases

Sex differences in outcomes of acute pancreatitis: Findings from a nationwide analysis

The role of in utero endotoxin exposure in the development of inflammatory bowel disease in mice

Contact Info

Product

Resources

About