“…The cardiac muscle is quantitatively the very important target tissues for insulin-stimulated glucose disposal which predominantly depends on GLUT4 [3,15,27]. The GLUT4 expression level is lower in cardiac muscle of animals and patients with type 2 diabetes [5,6,11,27]. Besides, previous studies revealed that in the myocardium of insulin resistant patients with cardiac hypertrophy and ischemic injury the GLUT4 contents were decreased, which represents an obstacle in glucose uptake into the cardiomyocytes [5,6,24,31].…”