The purpose of this study was to ascertain vocational interests and self-estimated work-relevant abilities of young adults with disabilities. Results showed that young adults with both low incidence and high incidence disabilities have a wide range of interests and self-estimated work-relevant abilities that are comparable to those in the general population. However, in this sample, less than 50% were employed in jobs that matched their Holland Theme interest/ability profiles. Suggestions for both employers and counselors to assist young adults with disabilities to work in employment that is satisfying and congruent with their vocational personalities are offered.The focus on the employment of people with disabilities is a critical concern of vocational psychologists. As we face worldwide economic challenges, the unemployment and misemployment of persons with disabilities and the cascading impacts these realities have on individuals can affect all aspects of their lives. Unemployment rates are especially high among adults with disabilities, who comprise approximately 20.4% of the U.S. population (National Council on Disability, 2008). Indeed, in 2009, the Bureau of Labor Statistics (BLS) reported that only 22.6% of persons with disabilities of working age were employed, compared to 71.9% of persons without disabilities. These statistics reflect persons with both low incidence disabilities (e.g., autism, blindness, deafness, severe cognitive disabilities) and high incidence disabilities (e.g., learning disabilities, communication disabilities, emotional/behavioral disorders, mild cognitive impairments, other health