Gender differences in Damp-Heat Syndrome: A review

Yuan, Shenfang; Wang, Ning; Wang, Junlei; Pan, Jin; Xue, Xiaoyan; Zhang, Yanan; Ma, Ting

doi:10.1016/j.biopha.2021.112128

Cited by 3 publications

(4 citation statements)

References 75 publications

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“…The dampness-heat pattern is the most common CM pattern in patients with T2DM and is also a hot spot for combined disease and CM pattern research [[ 35 ]]. To the best of our knowledge, this will be the first published study to generate machine-learning algorithms to distinguish the dampness-heat pattern of T2DM.…”

Section: Discussionmentioning

confidence: 99%

Application of machine learning in Chinese medicine differentiation of dampness-heat pattern in patients with type 2 diabetes mellitus

Liu¹,

Huang²,

Zhao³

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Application of machine learning in Chinese medicine differentiation of dampness-heat pattern in patients with type 2 diabetes mellitus

Liu¹,

Huang²,

Zhao³

et al. 2023

Heliyon

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“…Damp-heat syndrome evaluation based on these findings, ranging from general appearance, and gross pathology to objective blood indicators can be a favorable reference. Because current studies on damp-heat syndrome are mostly based on male subjects ( 7 ), our modeling and evaluation were also conducted with male mice. However, it is still worth noting that sex differences have been shown to affect the behavioral and pathological appearances of patients with damp-heat syndrome ( 7 ); this limitation in our study warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…Because current studies on damp-heat syndrome are mostly based on male subjects ( 7 ), our modeling and evaluation were also conducted with male mice. However, it is still worth noting that sex differences have been shown to affect the behavioral and pathological appearances of patients with damp-heat syndrome ( 7 ); this limitation in our study warrants further investigation. More attention should be given to sex differences when studying particular diseases, especially those susceptible to sex hormones.…”

Section: Discussionmentioning

confidence: 99%

“…Insights on this typical syndrome extend from conventionally febrile illness to psychosis, metabolic diseases, and various cancers (1)(2)(3)(4)(5)(6); ever-increasing research has been conducted to investigate damp-heat syndrome's essence for an evidence-based medical interpretation from the perspective of modern medicine. The historical origin, syndrome name determination, concept connotation, and main symptoms were summarized in Yuan's review, in which the bibliometric research underscored the broad prospect of damp-heat syndrome exploration (7). Given the limitations of clinical studies in mechanism mining, an appropriate animal model with damp-heat syndrome is imperative.…”

Section: Introductionmentioning

confidence: 99%

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A Mouse Model of Damp-Heat Syndrome in Traditional Chinese Medicine and Its Impact on Pancreatic Tumor Growth

Jiao

Cheng²,

Xu³

et al. 2022

Front. Oncol.

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BackgroundDamp-heat syndrome is one of the most important syndrome types in the traditional Chinese medicine (TCM) syndrome differentiation and treatment system, as well as the core pathogenesis of pancreatic cancer (PC) which remains a challenge to medical researchers due to its insidious onset and poor prognosis. Great attention has been given to the impact of damp-heat syndrome on tumorigenesis and progression, but less attention has been given to damp-heat modeling per se. Studying PC in a proper damp-heat syndrome animal model can recapitulate the actual pathological process and contribute to treatment strategy improvement.MethodsHere, an optimized damp-heat syndrome mouse model was established based on our prior experience. The Fibonacci method was applied to determine the maximum tolerated dosage of alcohol for mice. Damp-heat syndrome modeling with the old and new methods was performed in parallel of comparative study about general appearance, food intake, water consumption and survival. Major organs, including the liver, kidneys, lungs, pancreas, spleen, intestines and testes, were collected for histological evaluation. Complete blood counts and biochemical tests were conducted to characterize changes in blood circulation. PC cells were subcutaneously inoculated into mice with damp-heat syndrome to explore the impact of damp-heat syndrome on PC growth. Hematoxylin-eosin staining, Masson staining and immunohistochemistry were performed for pathological evaluation. A chemokine microarray was applied to screen the cytokines mediating the proliferation-promoting effects of damp-heat syndrome, and quantitative polymerase chain reaction and Western blotting were conducted for results validation.ResultsThe new modeling method has the advantages of mouse-friendly features, easily accessible materials, simple operation, and good stability. More importantly, a set of systematic indicators was proposed for model evaluation. The new modeling method verified the pancreatic tumor-promoting role of damp-heat syndrome. Damp-heat syndrome induced the proliferation of cancer-associated fibroblasts and promoted desmoplasia. In addition, circulating and tumor-located chemokine levels were altered by damp-heat syndrome, characterized by tumor promotion and immune suppression.ConclusionsThis study established a stable and reproducible murine model of damp-heat syndrome in TCM with systematic evaluation methods. Cancer associated fibroblast-mediated desmoplasia and chemokine production contribute to the tumor-promoting effect of damp-heat syndrome on PC.

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Identification of the therapeutic effect and molecular mechanism of Coptis chinensis Franch. and Magnolia officinalis var. biloba on chronic gastritis

Song

et al. 2023

Journal of Ethnopharmacology

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Gender differences in Damp-Heat Syndrome: A review

Cited by 3 publications

References 75 publications

Application of machine learning in Chinese medicine differentiation of dampness-heat pattern in patients with type 2 diabetes mellitus

Application of machine learning in Chinese medicine differentiation of dampness-heat pattern in patients with type 2 diabetes mellitus

A Mouse Model of Damp-Heat Syndrome in Traditional Chinese Medicine and Its Impact on Pancreatic Tumor Growth

Identification of the therapeutic effect and molecular mechanism of Coptis chinensis Franch. and Magnolia officinalis var. biloba on chronic gastritis

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