Gender Differences in COPD – Are Women More Susceptible to Smoking Effects?.

Soerheim, I; Johannessen, Ane; Bakke, Per; Gulsvik, Amund; Silverman, EK; DeMeo, DL

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3750

Cited by 2 publications

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“…4,25 Men and women may have differential susceptibility to the lung-damaging effects of cigarette smoking; in a large population study, females appear to have more severe COPD with early-onset disease (<60 yr) and a greater susceptibility to COPD with lower tobacco exposure. 6 Several studies have searched the biological background of possible greater susceptibility to cigarette smoke in women: several etiologies are possible. First, women could be genetically more predisposed to smoking-induced lung damage; second, there might be a greater dose-dependent effect in women smokers.…”

Section: Smokingmentioning

confidence: 99%

“…All those factors are mostly related to low socio-economic status associated with poverty, which disproportionately affects women. 6 Table 1 summarizes the gender differences in risk factors for COPD.…”

Section: Infectionsmentioning

confidence: 99%

“…3,5 Furthermore, several studies have suggested that women may have an increased susceptibility to the lung-damaging effects of smoking compared with men. 4,6 In underdeveloped and developing countries, COPD is still a men's disease and the rate of smoking in women is still less, which is about 10%. However, there have been other noxious sources such as biomass exposure and secondhand smoking that mainly affect women.…”

Section: Introductionmentioning

confidence: 99%

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Gender differences and chronic obstructive pulmonary disease: an update on the literature

Barbagelata

Nicolini

Ambrosino³

et al. 2018

Ital J Med

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Chronic obstructive pulmonary disease (COPD) has traditionally been viewed as a disease affecting older men with a history of smoking, while being neglected and under-diagnosed in women. This scenario has changed in recent years as there has been a steady increase in COPD prevalence and mortality rates in women. The increased prevalence of COPD among women is likely attributable to several factors including the increased rates of cigarette smoking observed in women during recent years, exposure to indoor air pollution as well as increased occupational exposures since women take on previously male-dominated occupational roles related to risk exposure. In this review we have analyzed the difference in COPD phenotypes and features related to gender difference.

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Section: Smokingmentioning

confidence: 99%

Section: Infectionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gender differences and chronic obstructive pulmonary disease: an update on the literature

Barbagelata

Nicolini

Ambrosino³

et al. 2018

Ital J Med

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Gender differences in COPD: are women more susceptible to smoking effects than men?

Sørheim

Johannessen

Gulsvik

et al. 2010

Thorax

275

198

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BackgroundThe number of female smokers developing chronic obstructive pulmonary disease (COPD) is rapidly increasing, but whether or not there exists a differential susceptibility by gender remains controversial. Methods How smoking behaviour and subsequent lung function reduction differed by gender was examined in a study including 954 subjects with COPD and 955 subjects without COPD. The study focused on two subgroups: subjects with COPD <60 years of age (earlyonset group, n¼316) and subjects with COPD with <20 pack-years of smoking (low exposure group, n¼241). Results In the low exposure group, female subjects with COPD had lower forced expiratory volume in 1 s (FEV 1 ) % predicted (48.7% vs 55.8%, p¼0.001) and more severe disease (50.4% vs 35.6%, p¼0.020, in GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage 3 and 4) than male subjects with COPD. Females also had lower FEV 1 % predicted (50.6% vs 56.0%, p¼0.006) and more severe COPD (41.7% vs 31.1% in GOLD stage 3 and 4, p¼0.050) in the early-onset group. Using multivariate regression, female gender was associated with 5.7% lower FEV 1 % predicted in the low exposure group (p¼0.012) and a similar trend was observed in the early-onset group (p¼0.057). The number of pack-years was not significantly associated with lung function in female subjects with COPD in this study, and the doseeresponse relationship between smoking and lung function differed by gender at lower levels of smoking exposure. Interaction analysis suggested that the effect of smoking on lung function might be different by gender (p¼0.027 in all subjects with COPD). Conclusions Female gender was associated with lung function reduction and more severe disease in subjects with COPD with early onset of disease or low smoking exposure. The findings may suggest a gender difference in susceptibility to the lung-damaging effects of cigarette smoking, but alternative explanations should be considered.For many years chronic obstructive pulmonary disease (COPD) was considered a disease of men, with higher global prevalence in men than in women. Today the number of women with COPD is rapidly increasing, and for the first time the number of deaths from COPD in women have surpassed those in men in the USA. 1 This development has been attributed to changes in the historical differences in smoking behaviour in men and women. Recent research has suggested that women may be more susceptible to the lungdamaging effects of smoking, but the findings are inconsistent. Several studies have indicated an increased female susceptibility to smoking-related decline in lung function, 2e7 whereas other studies have suggested an opposite gender effect.8 Whether or not there exists a differential susceptibility by gender remains controversial, and little is known about the mechanisms and implications of a possible gender difference in COPD.Maleefemale differences are often divided into sex-related (biological) and gender-related (environmental and socio-cultural) differences. 9 In this manuscript, w...

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Gender Differences in COPD – Are Women More Susceptible to Smoking Effects?.

Cited by 2 publications

References 0 publications

Gender differences and chronic obstructive pulmonary disease: an update on the literature

Gender differences and chronic obstructive pulmonary disease: an update on the literature

Gender differences in COPD: are women more susceptible to smoking effects than men?

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