Gender differences in clinical characteristic and in-hospital outcome in patients with takotsubo syndrome

Budnik, Monika; Nowak, Radosław; Fijałkowski, Marcin; Kochanowski, Janusz; Nargiełło, Ewa; Piątkowski, Radosław; Peller, Michał; Kucharz, Jakub; Jaguszewski, Miłosz; Gruchała, Marcin; Opolski, Grzegorz

doi:10.20452/pamw.14970

Cited by 9 publications

(27 citation statements)

References 4 publications

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“…Indeed, the incidence of cardiovascular diseases in post-menopausal women is equal to those in age-matched men [2]. Furthermore, there are a number of cardiovascular diseases that are more prevalent in women than in men, including Takotsubo cardiomyopathy [3,4] and microvascular angina [5]. Importantly, there are marked sex differences in the pathogenesis and/or clinical presentation of several cardiovascular diseases [6].…”

Section: Introductionmentioning

confidence: 99%

Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction

et al. 2020

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Sex-related differences in cardiovascular diseases are highly complex in humans and model-dependent in experimental laboratory animals. The objective of this work was to comprehensively investigate key sex differences in the response to acute and prolonged adrenergic stimulation in C57Bl/6NCrl mice. Cardiac function was assessed by trans-thoracic echocardiography before and after acute adrenergic stimulation (a single sub-cutaneous dose of isoproterenol 10 mg/kg) in 15 weeks old male and female C57Bl/6NCrl mice. Thereafter, prolonged adrenergic stimulation was achieved by sub-cutaneous injections of isoproterenol 10 mg/kg/day for 14 days in male and female mice. Cardiac function and morphometry were assessed by trans-thoracic echocardiography on the 15 th day. Thereafter, the mice were euthanized, and the hearts were collected. Histopathological analysis of myocardial tissue was performed after staining with hematoxylin & eosin, Masson's trichrome and MAC-2 antibody. Gene expression of remodeling and fibrotic markers was assessed by real-time PCR. Cardiac function and morphometry were also measured before and after isoproterenol 10 mg/kg/day for 14 days in groups of gonadectomized male and female mice and sham-operated controls. In the current work, there were no statistically significant differences in the positive inotropic and chronotropic effects of isoproterenol between male and female C57Bl/6NCrl. After prolonged adrenergic stimulation, there was similar degree of cardiac dysfunction, cardiac hypertrophy, and myocardial fibrosis in male and female mice. Similarly, prolonged isoproterenol administration induced hypertrophic and fibrotic genes in hearts of male and female mice to the same extent. Intriguingly, gonadectomy of male and female mice did not have a significant impact on isoproterenol-induced cardiac dysfunction as compared to sham-operated animals. The current work demonstrated lack of significant sex-related differences in isoproterenol-induced cardiac hypertrophy, dysfunction, and fibrosis in C57Bl/6NCrl mice. This study suggests that female sex may not be sufficient to protect the heart in this model of isoproterenol-induced cardiac dysfunction and underscores the notion that sexual dimorphism in cardiovascular diseases is highly model-dependent.

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Section: Introductionmentioning

confidence: 99%

Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction

et al. 2020

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“…Assessing sex differences in patients with takotsubo syndrome requires homogeneous cohorts Authors' reply We would like to thank Finsterer and Stöllberger for the interesting comment on our article. 1 We fully agree that the main limitation of the study is the small number of men included in the analysis, but this is due to rare occurrence of takotsubo syndrome (TTS) in men in general population. The percentage of men among patients with TTS is only about 10% worldwide.…”

Section: Letter To the Editormentioning

confidence: 65%

“…Sex differences were found with regard to the frequency of living alone (higher in men), frequency of physical triggers (higher in men), frequency of emotional triggers (higher in women), frequency of smoking (higher in men), peak level of N-terminal prohormone of brain natriuretic peptide (higher in women), frequency of ST -segment depression (higher in men), and reduced ejection fraction (higher in men), but no sex difference was reported for in -hospital outcomes. 1 Based on that, we have the following comments and concerns.…”

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confidence: 99%

Assessing sex differences in patients with takotsubo syndrome requires homogeneous cohorts. Authors' reply

Budnik

Opolski

2020

Polish Archives of Internal Medicine

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“…To date, interesting results have been published involving single-center experience regarding markers used in TTS diagnosis, sex differences, application of the GRACE scale, and poor prognosis of patients with chronic kidney disease or low body mass index (BMI) [10][11][12][13][14]. It would, however, be extremely valuable to verify these results for a large-scale population.…”

Section: Resultsmentioning

confidence: 99%

Pol-tako — the first, nationwide Polish multicenter analysis of patients with takotsubo syndrome

et al. 2021

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Gender differences in clinical characteristic and in-hospital outcome in patients with takotsubo syndrome

Cited by 9 publications

References 4 publications

Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction

Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction

Assessing sex differences in patients with takotsubo syndrome requires homogeneous cohorts. Authors' reply

Pol-tako — the first, nationwide Polish multicenter analysis of patients with takotsubo syndrome

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