Gender Differences in Clinical, Angiographic and Procedural Profiles between Young Patients with Acute Coronary Syndrome undergoing Percutaneous Coronary Intervention

Cader, Fathima Aaysha; Rahman, Afzalur; Ullah, Mohammad; Rahman, Mohammad Arifur; Alam, Shariful; Nasrin, Sahela; Momen, Abdul; Kundu, Samir Kumar; Chakraborty, Shubhra; Bala, Poppy

doi:10.3329/cardio.v10i2.36277

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…In case of PCI and NSTE-ACS [13][14] , the rate was quite high in case of women. These findings are consistent with the previous reports where similar success ratio was found between men and women 15 .…”

Section: Discussionsupporting

confidence: 94%

Gender Differences in Percutaneous Coronary Intervention Insights from the Coronary Angiography

Ahmed¹,

Shabir²

2022

PJMHS

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Background: The data from the prior studies have reported inconsistencies in the comorbidity burden, and baseline risk profile. Objective: The data provide insights into the sex difference in percutaneous coronary interventions. Study design: It is a retrospective study with statistical approach, conducted in the Department of Cardiology, Rehman Medical Institute Peshawar. Material and Methods: The study was conducted from December 2021 to May 2022. The 400 patients visited the cardiology department of the hospital were included in the study. The selected patients were enrolled in the coronary angiography. The data was collected from cardiology department of two hospitals and analyzed. The ethical and review committee of the hospital approved the study. The informed consent was taken from the selected patients. The data contains demographic features, baselines characteristics, hospital complications and PCI course. The patients having residual stenosis of less than 50% after balloon angioplasty were included in the groups rated as successful PCI groups. Results: Out of 400 patients taken from two hospitals there were 50% female. The women included in the study were 5 years older than the male patients. Women were on average 67 years old and men were 72 years old. Women in general had more cases of coronary angiography, also women were reported with cases like diabetes mellitus, and some of the cases reported congestive heart failure. The success of the procedure was more successful in case of women with 95% of female patients receiving successful procedure. Conclusions: The overview of sex linked variations in PCI was observed in this study. The hospital mortality was found to be high in case of women, there was also not significant differences found between hospital mortalities for NSTE-2CS in case of cardiogenic problems Keywords: Percutaneous coronary interventions (PCI), coronary angiography, cardiogenic shock, Non-ST elevation acute coronary syndrome (NSTE-ACS) and myocardial infraction.

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Section: Discussionsupporting

confidence: 94%

Gender Differences in Percutaneous Coronary Intervention Insights from the Coronary Angiography

Ahmed¹,

Shabir²

2022

PJMHS

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“…The South Asian nations of India, Pakistan, Bangladesh, Sri Lanka, and Nepal account for about a quarter of the world’s population and contribute the highest proportion of the world’s CVD burden, many of whom are also young [ 103 ]. There are considerable data on sex differences of ACS in the region, particularly from India [ 11 , 12 , 106 , 107 , 108 ] and Bangladesh [ 18 , 105 , 109 , 110 ], albeit women comprising less than a quarter of participants [ 11 , 12 , 105 , 106 ]. Demographics were similar to global patterns, with women being older, with more CV risk factors, notably more diabetes and hypertension [ 11 , 12 , 105 , 106 , 107 , 108 , 109 , 111 , 112 ].…”

Section: South-east Asian Region (Sear)mentioning

confidence: 99%

“…There are considerable data on sex differences of ACS in the region, particularly from India [ 11 , 12 , 106 , 107 , 108 ] and Bangladesh [ 18 , 105 , 109 , 110 ], albeit women comprising less than a quarter of participants [ 11 , 12 , 105 , 106 ]. Demographics were similar to global patterns, with women being older, with more CV risk factors, notably more diabetes and hypertension [ 11 , 12 , 105 , 106 , 107 , 108 , 109 , 111 , 112 ]. Sex-based analyses of Indian ACS registries reveal conflicting evidence on ACS care [ 11 , 12 , 106 , 108 ].…”

Section: South-east Asian Region (Sear)mentioning

confidence: 99%

Sex Differences in Acute Coronary Syndromes: A Global Perspective

Cader

Banerjee

Gulati

2022

JCDD

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Despite increasing evidence and improvements in the care of acute coronary syndromes (ACS), sex disparities in presentation, comorbidities, access to care and invasive therapies remain, even in the most developed countries. Much of the currently available data are derived from more developed regions of the world, particularly Europe and the Americas. In contrast, in more resource-constrained settings, especially in Sub-Saharan Africa and some parts of Asia, more data are needed to identify the prevalence of sex disparities in ACS, as well as factors responsible for these disparities, particularly cultural, socioeconomic, educational and psychosocial. This review summarizes the available evidence of sex differences in ACS, including risk factors, pathophysiology and biases in care from a global perspective, with a focus on each of the six different World Health Organization (WHO) regions of the world. Regional trends and disparities, gaps in evidence and solutions to mitigate these disparities are also discussed.

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“…However, this finding is in contrast to that of Cader et al who showed that women tended to have a better ejection fraction and less severe coronary involvement. 24 This study highlights data from our part of world, as data on gender differences in young adults who presented with ACS are sparse. Our results were similar to those of earlier studies (but they were from an older age population) and our study emphasized that young women were relatively older in age, sought medical attention later, and had poor overall outcomes than men.…”

Section: Discussionmentioning

confidence: 81%

Impact of Gender on the Clinical Features, Angiographic Findings, and Outcomes of Young Patients Presented With Acute Coronary Syndrome

et al. 2022

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Objectives: Acute coronary syndrome (ACS) at a younger age is now becoming a crucial problem. This study determined the effect of gender on the clinical findings and outcomes of young patients (≤ 45 years) with ACS. Methodology: In this descriptive cross sectional study, young patients (≤45 years) who presented with ACS and underwent coronary angiography were recruited. The comparison of clinical profile, angiographic findings, in-hospital, and 90-days mortality between genders were made. Results: A total of 335 young patients with ACS were included, 80.6% of whom were men. A significant difference was found between men and women in terms of mean age: 38±6 vs. 40±5 (p=0.014), hypertension: 37.8% vs. 58.5% (p=0.002), diabetes: 17.4% vs. 35.4% (p=0.001), smoking: 50.4% vs. 6.2% (p≤0.001), use of smokeless tobacco: 14.1% vs. 4.6% (p=0.037), median time from symptom onset to first medical contact: 270 [420–165] minutes vs. 346 [499.5–240] minutes (p=0.047), ST-segment elevation myocardial infarction (STEMI) 89.6% vs. 78.5% (p=0.015), non-ST-elevation myocardial infarction (NSTEMI) 8.5% vs. 18.5% (p=0.019), and three-vessel disease (3VD) 10.7% vs. 21.5% (p=0.019), respectively. In-hospital and 90-day mortality rates were 0.4% vs. 3.1% (p=0.097) and 1.5% vs. 4.6% (p=0.136) for men and women, respectively. Conclusion: Women tended to have a higher age at presentation, more frequent traditional risk factors, late presentation after symptom onset, frequent NSTEMI, and 3VD, whereas men were distinct with frequent STEMI and higher tobacco use. In addition, women trended to have a higher in-hospital as well as short-term mortality than men did.

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Gender Differences in Clinical, Angiographic and Procedural Profiles between Young Patients with Acute Coronary Syndrome undergoing Percutaneous Coronary Intervention

Cited by 3 publications

References 20 publications

Gender Differences in Percutaneous Coronary Intervention Insights from the Coronary Angiography

Gender Differences in Percutaneous Coronary Intervention Insights from the Coronary Angiography

Sex Differences in Acute Coronary Syndromes: A Global Perspective

Impact of Gender on the Clinical Features, Angiographic Findings, and Outcomes of Young Patients Presented With Acute Coronary Syndrome

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