Gender differences in clinical and biochemical parameters of patients consecutively hospitalized for unipolar depression

Ceresa, Alessandro; Esposito, Cecilia Maria; Surace, Teresa; Legnani, F; Cirella, Luisa; Cetti, Denise; Paolo, M. Di; Nosari, Guido; Quarantini, Francesco Zanelli; Serati, Marta; Ciappolino, Valentina; Caldiroli, Alice; Capuzzi, Enrico; Buoli, Massimiliano

doi:10.1016/j.psychres.2022.114476

Cited by 11 publications

(12 citation statements)

References 56 publications

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“…In the current study, the prevalence of depressive symptoms was signi cantly higher in women with relatively lower uric acid levels than in those with high uric acid levels. This nding is in agreement with previous studies that have shown that women with depression have lower plasma levels of uric acid 17,24 . In particular, the results of the study on older adults in the Korean population are consistent with the ndings that used KNHANES data from 2016 18 .…”

Section: Discussionsupporting

confidence: 93%

Association between uric acid and depressive symptoms in older adults: The Korea National Health and Nutrition Examination Survey

Kim

Park

et al. 2022

Preprint

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Uric acid is known for its antioxidant capacity; however, whether uric acid is independently associated with depression in the older population remains controversial. The current study aimed to investigate the association between uric acid and depressive symptoms in older adults according to sex, using a large national sample population. Data from the 2016, 2018, and 2020 Korean National Health and Nutrition Examination Surveys were analyzed, and 5609 participants older than 60 years were included in this study. We defined a Patient Health Questionnaire-9 score ≥ 5 as indicating the presence of depressive symptoms. The prevalence of depressive symptoms was higher in women with lower uric acid levels than in those with higher uric acid levels. In women, uric acid was significantly associated with depressive symptoms in the multivariable logistic regression analysis (odds ratio, 1.36; 95% confidence interval, 1.10–1.68; p = 0.005). However, no significant association between uric acid levels and depressive symptoms was observed in men. The findings of this study suggest that uric acid is associated with depressive symptoms in older women, but not in men. Further research is needed on sex differences in the relationship between serum uric acid levels and depressive symptoms.

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Section: Discussionsupporting

confidence: 93%

Association between uric acid and depressive symptoms in older adults: The Korea National Health and Nutrition Examination Survey

Kim

Park

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…This finding is in agreement with previous studies that have shown that women with depression have lower plasma levels of uric acid. 17,31 In particular, the results of the study on older adults in the Korean population are consistent with the findings that used KNHANES data from 2016. 18 This sex-specific difference may be attributed to the susceptibility of women to oxidative stress, which is a major factor in depression.…”

Section: P-valuesupporting

confidence: 85%

Association between uric acid and depressive symptoms in older adults: The Korea National Health and Nutrition Examination Survey

Kim

Park

et al. 2023

Int J Geriat Psychiatry

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“…The levels of serum and plasma UA in patients with depression and CMS rats were lower than in control, which was a depression biomarker (Peng et al, 2016 ; Xiong et al, 2016 ; Meng et al, 2020 ; Yuan et al, 2021 ; Ceresa et al, 2022 ). Plasma UA-adjusted mean levels were lower in current major depressive disorder compared to remitted disorders and controls (Black et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis

Chen

Zhou

Chen

et al. 2022

Front. Mol. Neurosci.

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Major depression (MD) is a severe mental illness that creates a heavy social burden, and the potential molecular mechanisms remain largely unknown. Lots of research demonstrate that the olfactory bulb is associated with MD. Recently, gas chromatography-mass spectrometry-based metabolomic studies on depressive rats indicated that metabolisms of purine and lipids were disordered in the olfactory bulb. With various physicochemical properties and extensive concentration ranges, a single analytical technique could not completely cover all metabolites, hence it is necessary to adopt another metabolomic technique to seek new biomarkers or molecular mechanisms for depression. Therefore, we adopted a liquid chromatography-mass spectrometry metabonomic technique in the chronic mild stress (CMS) model to investigate significant metabolic changes in the olfactory bulb of the mice. We discovered and identified 16 differential metabolites in the olfactory bulb of the CMS treatments. Metabolic pathway analysis by MetaboAnalyst 5.0 was generated according to the differential metabolites, which indicated that the tryptophan metabolism pathway was the core pathogenesis in the olfactory bulb of the CMS depression model. Further, the expressions of tryptophan hydroxylase (TpH) and aromatic amino acid decarboxylase (AAAD) were detected by western blotting and immunofluorescence staining. The expression of TpH was increased after CMS treatment, and the level of AAAD was unaltered. These results revealed that abnormal metabolism of the tryptophan pathway in the olfactory bulb mediated the occurrence of MD.

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Gender differences in clinical and biochemical parameters of patients consecutively hospitalized for unipolar depression

Cited by 11 publications

References 56 publications

Association between uric acid and depressive symptoms in older adults: The Korea National Health and Nutrition Examination Survey

Association between uric acid and depressive symptoms in older adults: The Korea National Health and Nutrition Examination Survey

Association between uric acid and depressive symptoms in older adults: The Korea National Health and Nutrition Examination Survey

Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis

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