Gender differences in chronic obstructive pulmonary diseases: a narrative review

Nicolini, Antonello; Barbagelata, Elena; Tagliabue, Elena; Colombo, Daniela; Monacelli, Fiammetta; Braido, Fulvio

doi:10.23736/s0031-0808.18.03463-8

Cited by 20 publications

(13 citation statements)

References 67 publications

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“…Men and women evaluated health status differently. Females pay more attention to dyspnea, emotions, and anxiety; and they had more comorbidities [5,72]. The present study demonstrated that females had (nonsignificant) larger MCID estimates for improvement and smaller ones for deterioration.…”

Section: Gender Age and Comorbiditiesmentioning

confidence: 50%

Baseline health status and setting impacted minimal clinically important differences in COPD: an exploratory study

Alma

Jong

Jelusic

et al. 2019

Journal of Clinical Epidemiology

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Objectives: Minimal clinically important differences (MCIDs) are used as fixed numbers in the interpretation of clinical trials. Little is known about its dynamics. This study aims to explore the impact of baseline score, study setting, and patient characteristics on health status MCIDs in chronic obstructive pulmonary disease (COPD). Study Design and Setting: Baseline and follow-up data on the COPD Assessment Test (CAT), Clinical COPD Questionnaire (CCQ), and St. George's Respiratory Questionnaire (SGRQ) were retrospectively analyzed from pulmonary rehabilitation (PR) and routine clinical practice (RCP). Anchor-and distribution-based MCID estimates were calculated and tested between settings, gender, age, Global initiative Funding: The main RIMTCORE trial (#DRKS00004609) was funded by the Deutsche Rentenversicherung, Germany. The Dutch observational study on COPD health status in routine clinical practice (MCID study) as well as the current combined retrospective analysis of both studies received financial support from the Junior Scientific Masterclass (JSM) as part of the

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Section: Gender Age and Comorbiditiesmentioning

confidence: 50%

Baseline health status and setting impacted minimal clinically important differences in COPD: an exploratory study

Alma

Jong

Jelusic

et al. 2019

Journal of Clinical Epidemiology

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“…Gender differences in the clinical presentation and prognosis for COPD have been previously described. 25,[71][72][73][74] For example, women have more severe COPD symptoms than men, 25 despite less smoking exposure history. 61,71 Furthermore, women have a greater risk of exacerbations (after adjusting for smoking) 24,25 and, COPD-related hospitalization and death compared with men.…”

Section: Discussionmentioning

confidence: 99%

“…75,76 Other factors, such as comorbidities and adherence to treatment may also differ between men and women and should be considered. 72,74 A goal of this literature review was to investigate biological factors potentially underlying these differences. Overall, we found the number of such studies to be limited.…”

Section: Discussionmentioning

confidence: 99%

<p>Chronic Obstructive Pulmonary Disease in Women: A Biologically Focused Review with a Systematic Search Strategy</p>

Han

2020

COPD

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Purpose: Evidence suggests that chronic obstructive pulmonary disease (COPD) symptoms and progression may differ between men and women. However, limited information is currently available on the pathophysiological and biological factors that may underlie these sex-related differences. The objective of this review is to systematically evaluate reports of potential sexrelated differences, including genetic, pathophysiological, structural, and other biological factors, that may influence COPD development, manifestation, and progression in women. Patients and Methods: A PubMed literature search was conducted from inception until January 2020. Original reports of genetic, hormonal, and physiological differences, and biological influences that could contribute to COPD development, manifestation, and progression in women were included. Results: Overall, 491 articles were screened; 29 articles met the inclusion criteria. Results from this analysis demonstrated between-sex differences in inflammatory, immune, genetic, structural, and physiological factors in patients with COPD. Conclusion: Various biological differences are observed between men and women with COPD including differences in inflammatory and metabolic pathways related to obesity and fat distribution, immune cell function and autophagy, extent and distribution of emphysema and airway wall remodeling. An enhanced understanding of these differences has the potential to broaden our understanding of how COPD develops and progresses, thereby providing an opportunity to ultimately improve diagnosis, treatment, and monitoring of COPD in both men and women.

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“…COPD is estimated to become the third leading cause of death in the world by 2020, which is an alarming news (1). COPD is generally considered to be more prevalent in men than in women (4). Smoking is a growing habit in women in developing and developed countries, and exposure to biomass fuel for domes-tic purposes is also a recognized risk factor of COPD among women.…”

Section: Introductionmentioning

confidence: 99%

“…Smoking is a growing habit in women in developing and developed countries, and exposure to biomass fuel for domes-tic purposes is also a recognized risk factor of COPD among women. As a matter of fact, women often develop more severe COPD compared to men if they are ever exposed to tobacco, which could be due to a genetic predisposition (4).…”

Section: Introductionmentioning

confidence: 99%

The Burden of Chronic Obstructive Pulmonary Disease and Its Risk Factors in the Iranian Population: Results from the Global Burden of Disease Study 2016

Izadi

2018

Int J Health Life Sci

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Background: Chronic obstructive pulmonary disease (COPD) is an important public health challenge. This report studies the burden of COPD and its risk factors in the Iranian population. Methods: This study has used the data from a study by the Institute for Health Metrics and Evaluation (IHME) on the disability adjusted life year (DALY) of COPD and its risk factors in Iran in 2016. Results: Based on the IHME results, the DALY was 201.8 per 100 000 population in 1999 and 303.1 per 100 000 population in 2016. About 0.47% of the total estimated DALYs in Iran (1990) were related to COPD. The risk of COPD attributable to tobacco was 140.3 DALYs per 100 000, and air pollution and occupational hazards were responsible for 98.4 and 39.5 DALYs per 100 000 population. In Iran, the DALY of COPD attributable to behavioral and environmental risk factors was 75.7% in 1990 and 91.6% in 2016. Conclusions: Health policy makers need to have a holistic approach in order to decrease the burden of COPD in the future years. Targeting behavioral and environmental risk factors requires a strong organizational and social commitment to health.

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Gender differences in chronic obstructive pulmonary diseases: a narrative review

Cited by 20 publications

References 67 publications

Baseline health status and setting impacted minimal clinically important differences in COPD: an exploratory study

Baseline health status and setting impacted minimal clinically important differences in COPD: an exploratory study

<p>Chronic Obstructive Pulmonary Disease in Women: A Biologically Focused Review with a Systematic Search Strategy</p>

The Burden of Chronic Obstructive Pulmonary Disease and Its Risk Factors in the Iranian Population: Results from the Global Burden of Disease Study 2016

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