Gender Differences in Cerebral Regional Homogeneity of Adult Healthy Volunteers: A Resting-State fMRI Study

Abstract

Objective. We sought to use the regional homogeneity (ReHo) approach as an index in the resting-state functional MRI to investigate the gender differences of spontaneous brain activity within cerebral cortex and resting-state networks (RSNs) in young adult healthy volunteers. Methods. One hundred and twelve healthy volunteers (56 males, 56 females) participated in the resting-state fMRI scan. The ReHo mappings in the cerebral cortex and twelve RSNs of the male and female groups were compared. Results. We found statistically significant gender differences in the primary visual network (PVN) (P < 0.004, with Bonferroni correction) and left attention network (LAtN), default mode network (DMN), sensorimotor network (SMN), executive network (EN), and dorsal medial prefrontal network (DMPFC) as well (P < 0.05, uncorrected). The male group showed higher ReHo in the left precuneus, while the female group showed higher ReHo in the right middle cingulate gyrus, fusiform gyrus, left inferior parietal lobule, precentral gyrus, supramarginal gyrus, and postcentral gyrus. Conclusions. Our results suggested that men and women had regional specific differences during the resting-state. The findings may improve our understanding of the gender differences in behavior and cognition from the perspective of resting-state brain function.

Brain changes associated with cognitive and emotional factors in chronic pain: A systematic review

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Reproducibility of R‐fMRI metrics on the impact of different strategies for multiple comparison correction and sample sizes

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Reproducibility of R-fMRI Metrics on the Impact of Different Strategies for Multiple Comparison Correction and Sample Sizes

“…Sex differences were chosen because sex is an objective category that can be readily investigated across large scale datasets. To wit, differences in brain function between men and women have been well documented in the R-fMRI literature (Allen, et al, 2011;Bluhm, et al, 2008;Filippi, et al, 2013;Hjelmervik, et al, 2014;Kilpatrick, et al, 2015;Scheinost, et al, 2015;Tomasi and Volkow, 2012;Xu, et al, 2015). We chose to examine differences between EO and EC conditions to test whether our approach to within-subject designs.…”