Gender differences in brain regional homogeneity of healthy subjects after normal sleep and after sleep deprivation: A resting-state fMRI study

Dai, Xuesong; Gong, Honghan; Wang, Yixiang; Zhou, Fuqing; Min, You-jiang; Zhao, Feng; Wang, Si-Yong; Liu, Bixia; Xiangzuo, Xiao

doi:10.1016/j.sleep.2011.09.019

Cited by 120 publications

(123 citation statements)

References 31 publications

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“…5,35 These studies provided supported evidence that the hyperarousal model is a core predisposing or perpetuating factor of chronic insomnia. 36 Our previous sleep deprivation study found that the female sleep deprivation subjects showed hyperarousal re-activation in the bilateral occipital gyrus compared with the GS-Fs, 21 and our previous regional homogeneity study demonstrated the excessive hyperarousal reactivities in the temporal lobe in the PCPIs, PCPI-Ms and PCPI-Fs, and the excessive hyperarousal reactivation in the occipital cortex in the PCPI-Fs. 23 The vision-related regions were not only activated by real vision, but also by visual mental imagery, 37,38 since the visual cortex was relevant to emotional activities, as emotional changes could lead to higher BOLD signal regions in the visual cortex.…”

Section: Discussionmentioning

confidence: 81%

“…21 In this study, there was a lopsided sex ratio in PCPIs, and 23 PCPIs had taken medications before. However, whether the medication or gender had any effects is still unknown.…”

Section: Groupsmentioning

confidence: 73%

“…Therefore, the excessive hyperarousal reactivities in the visual cortex and temporal lobe may be a core predisposing or perpetuating factor of ultimately hampering the ability to initiate or maintain sleep. Our previous sleep deprivation study found that the occipital gyrus was strengthened in the females and weakened in the males from a rested wakeful status to a sleep deprivation status, 21 which may explain why the PCPI-Ms had few lower ALFF response in the occipital gyrus.…”

Section: Discussionmentioning

confidence: 93%

“…21,22 However, whether chronic primary insomnia shows analogous outcomes remains unclear. In this study, we hypothesized that the PCPIs also shows aberrant regional brain activity and gender differences in the regional brain activity.…”

Section: Introductionmentioning

confidence: 99%

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Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia: Evidence from a Resting-State fMRI Study

Dai

Nie

Liu

et al. 2016

Journal of Clinical Sleep Medicine

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113

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Study Objectives: To explore the regional brain activities in patients with chronic primary insomnia (PCPIs) and their sex differences. Methods: Forty-two PCPIs (27 females, 15 males) and 42 good sleepers (GSs; 24 females, 18 males) were recruited. Six PCPIs (3 males, 3 females) were scanned twice by MRI to examine the test-retest reliability. Amplitude of low frequency fluctuation (ALFF) method was used to assess the local brain features. The mean signal values of the different ALFF areas were analyzed with a receiver operating characteristic (ROC) curve. Simple linear regression analysis was performed to investigate the relationships between clinical features and different brain areas. Results: Both female and male PCPIs showed higher ALFF in the temporal lobe and occipital lobe, especially in female PCPIs. Female PCPIs had lower ALFF in the bilateral cerebellum posterior lobe, left dorsolateral prefrontal cortex, and bilateral limbic lobe; however, male PCPIs showed lower ALFF in the left occipital gyrus. The mean signal value of the cerebellum in female PCPIs showed negative correlations with negative emotions. Compared with male PCPIs, female PCPIs showed higher ALFF in the bilateral middle temporal gyrus and lower ALFF in the left limbic lobe. The different areas showed high testretest stability (Clusters of contiguous volumes ≥ 1080 mm 3 with an intraclass correlation coefficient ≥ 0.80) and high degree of sensitivity and specificity. Conclusions: Female PCPIs showed more regional brain differences with higher and lower ALFF responses than male PCPIs. However, they shared analogous excessive hyperarousal mechanism and wide variations in aberrant brain areas. I NTRO DUCTI O NPatients with chronic primary insomnia (PCPIs), who underwent the subjective experience of chronically disturbed sleep, sleep loss, non-refreshing sleep, and heightened arousal in bed with impaired quality of life, showed a decreased ability to disengage from external information processing at sleep onset.1-3 Occasional episodes of insomnia symptoms are reported in half of all adults, while chronic insomnia is prevalent in 10-15% of the adult population. 4 In spite of a recent increase in neuroimaging research into PCPIs, it has not gleaned a consistent conclusion about its neuropathology after reviewing the neuroimaging studies of primary insomnia, especially with regard to the structural studies of brain alterations. 5 The results of structural studies are either contradictory or required replication. Altena et al. found that PCPIs had a smaller volume of reduced gray matter in the precuneus and left orbitofrontal cortex which strongly correlated with the subjective severity of insomnia, but increased gray matter volume was not found. 6 Joo et al. demonstrated significantly reduced gray matter concentrations in the dorsolateral prefrontal and pericentral cortices, superior temporal gyrus, and cerebellum, and decreased gray matter volumes in the medial frontal lobe and middle temporal lobe in PCPIs compared with good sleepers (GSs), ...

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Section: Discussionmentioning

confidence: 81%

“…21 In this study, there was a lopsided sex ratio in PCPIs, and 23 PCPIs had taken medications before. However, whether the medication or gender had any effects is still unknown.…”

Section: Groupsmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia: Evidence from a Resting-State fMRI Study

Dai

Nie

Liu

et al. 2016

Journal of Clinical Sleep Medicine

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113

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“…Concerning the influence of gender on the RSN, a few studies have been conducted with mixed results: there is evidence for gender differences in resting‐state FC (rs‐FC) in specific brain regions such as the amygdala (Dai et al., 2012; Kogler et al., 2016), insula (Li, Qin, Jiang, Zhang, & Yu, 2012) and within the sensorimotor network (Allen et al., 2011). In addition, men showed stronger connectivity in parieto‐temporal regions, and within cognitive and sensory networks.…”

Section: Introductionmentioning

confidence: 99%

Male‐to‐female gender dysphoria: Gender‐specific differences in resting‐state networks

et al. 2017

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IntroductionRecent research found gender‐related differences in resting‐state functional connectivity (rs‐FC) measured by functional magnetic resonance imaging (fMRI). To the best of our knowledge, there are no studies examining the differences in rs‐FC between men, women, and individuals who report a discrepancy between their anatomical sex and their gender identity, i.e. gender dysphoria (GD).MethodsTo address this important issue, we present the first fMRI study systematically investigating the differences in typical resting‐state networks (RSNs) and hormonal treatment effects in 26 male‐to‐female GD individuals (MtFs) compared with 19 men and 20 women.ResultsDifferences between male and female control groups were found only in the auditory RSN, whereas differences between both control groups and MtFs were found in the auditory and fronto‐parietal RSNs, including both primary sensory areas (e.g. calcarine gyrus) and higher order cognitive areas such as the middle and posterior cingulate and dorsomedial prefrontal cortex. Overall, differences in MtFs compared with men and women were more pronounced before cross‐sex hormonal treatment. Interestingly, rs‐FC between MtFs and women did not differ significantly after treatment. When comparing hormonally untreated and treated MtFs, we found differences in connectivity of the calcarine gyrus and thalamus in the context of the auditory network, as well as the inferior frontal gyrus in context of the fronto‐parietal network.ConclusionOur results provide first evidence that MtFs exhibit patterns of rs‐FC which are different from both their assigned and their aspired gender, indicating an intermediate position between the two sexes. We suggest that the present study constitutes a starting point for future research designed to clarify whether the brains of individuals with GD are more similar to their assigned or their aspired gender.

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Gender‐related difference in altered fractional amplitude of low‐frequency fluctuations after electroacupuncture on primary insomnia patients: A resting‐state fMRI study

Shi

Wang

et al. 2020

Brain and Behavior

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Gender differences in brain regional homogeneity of healthy subjects after normal sleep and after sleep deprivation: A resting-state fMRI study

Cited by 120 publications

References 31 publications

Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia: Evidence from a Resting-State fMRI Study

Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia: Evidence from a Resting-State fMRI Study

Male‐to‐female gender dysphoria: Gender‐specific differences in resting‐state networks

Gender‐related difference in altered fractional amplitude of low‐frequency fluctuations after electroacupuncture on primary insomnia patients: A resting‐state fMRI study

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