Gender Differences in Bipolar Disorder

López-Zurbano, Saioa; González‐Pinto, Ana

doi:10.1007/978-3-030-15179-9_31

Cited by 3 publications

(3 citation statements)

References 80 publications

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“…Females show increased frequency of hypomania and more rapid cycling between manic and depressive states. Atypical depression symptoms are more common in BD females, and there is a higher risk for manic-depressive cycles during menopause and around childbirth, which has been attributed to intense hormonal fluctuations[López-Zurbano and González-Pinto, 2019;Sit, 2004]. Females are more frequently treated for BD with typical psychotropic medication (antidepressants, benzodiazepines) and cognitive behavioral therapy, whereas males are more commonly treated with lithium [López-Zurbano and González-Pinto, 2019].…”

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confidence: 99%

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Salminen¹,

Tubi²,

Bright³

et al. 2020

Preprint

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Sex differences are found in the incidence and expression of psychiatric and neurodegenerative conditions, and many studies suggest these differences are influenced by innate biological differences between males and females and risk factors that interact with these differences. However, few studies have used neuroimaging to examine brain signatures of disease separately by sex, and many studies of sex differences have been based on small samples and their findings have not been replicated in larger cohorts. Large-scale neuroimaging initiatives such as the Enhancing NeuroImaging Genetics through Meta-Analyses (ENIGMA) consortium, the UK Biobank, Human Connectome Project, and others offer an unprecedented source of power to address important questions about the role of sex as a risk or protective factor for suboptimal brain health, as well as sex-specific neuroimaging phenotypes in brain-related illnesses. Here we review the existing neuroimaging literature on sex differences in the human brain in healthy adults and those with the most common and debilitating psychiatric and age-related neurodegenerative conditions. Finally, we discuss key gaps in this literature and opportunities of large-scale collaborative efforts to identify, characterize, and explain how biological sex influences the humanbrain in health and disease.

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confidence: 99%

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Salminen¹,

Tubi²,

Bright³

et al. 2020

Preprint

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“…10 Women may be more likely to present with predominant depressive features and mixed symptoms, which may render them less likely to receive accurate diagnosis and timely treatment. 11 Further, comorbid gender-specific disorders, such as premenstrual dysphoric disorder, may complicate the accurate diagnosis and treatment of bipolar disorder. 12 Given the complexities of bipolar disorder in women of childbearing age, the purpose of this paper is to provide an overview of the differential diagnosis and management of bipolar disorder in women of childbearing age.…”

Section: Introductionmentioning

confidence: 99%

“…Rates of bipolar disorder in pregnant women at delivery are estimated at nearly 2% 10 . Women may be more likely to present with predominant depressive features and mixed symptoms, which may render them less likely to receive accurate diagnosis and timely treatment 11 . Further, comorbid gender‐specific disorders, such as premenstrual dysphoric disorder, may complicate the accurate diagnosis and treatment of bipolar disorder 12 .…”

Section: Introductionmentioning

confidence: 99%

Bipolar disorder: Treatment strategies for women of childbearing age

Kameg

2020

Perspect Psychiatr Care

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Purpose: Bipolar disorder is associated with increased rates of morbidity and mortality, magnified in women of childbearing age. The purpose of this paper is to provide an overview of the differential diagnosis and management of bipolar disorder in women of childbearing age.Conclusions: Differential diagnoses for bipolar disorder include depressive disorders, anxiety disorders, trauma-related disorders, attention-deficit/hyperactivity disorder, and personality disorders. Pharmacotherapeutic options for the treatment of bipolar disorder include lithium, anti-epileptic medications, and atypical antipsychotics. In regard to women of childbearing age, consideration of risks, benefits, and alternative therapies is needed before initiating therapy.Practice Implications: Caring for patients with bipolar disorder, particularly women of childbearing age, requires careful differentiation of bipolar disorder from other mental health problems, and prudent consideration of pharmacotherapeutic options.

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Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Salminen

Tubi

Bright

et al. 2021

Human Brain Mapping

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Sex is a biological variable that contributes to individual variability in brain structure and behavior. Neuroimaging studies of population-based samples have identified normative differences in brain structure between males and females, many of which are exacerbated in psychiatric and neurological conditions. Still, sex differences in MRI outcomes are understudied, particularly in clinical samples with known sex differences in disease risk, prevalence, and expression of clinical symptoms. Here we review the existing literature on sex differences in adult brain structure in normative samples and in 14 distinct psychiatric and neurological disorders. We discuss commonalities and sources of variance in study designs, analysis procedures, disease subtype effects, and the impact of these factors on MRI interpretation. Lastly, we identify key problems in the neuroimaging literature on sex differences and offer potential recommendations to address current barriers and optimize rigor and reproducibility. In particular, we emphasize the importance of large-scale neuroimaging initiatives such as the Enhancing NeuroImaging Genetics through Meta-Analyses consortium, the UK Biobank, Human Connectome Project, and others to provide unprecedented power to evaluate sex-specific phenotypes in major brain diseases.

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Gender Differences in Bipolar Disorder

Cited by 3 publications

References 80 publications

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Bipolar disorder: Treatment strategies for women of childbearing age

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

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