Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood

Schutová, Barbora; Hrubá, Lenka; Rokyta, Richard; Šlamberová, Romana

doi:10.1002/dev.21016

Cited by 37 publications

(34 citation statements)

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“…Prenatal methamphetamine alters exploratory behavior and locomotor activity in adult rats (39). Thus, locomotor activity was measured as a "positive control" to verify that our methamphetamine treatments produced a behavioral effect that is consistent with previous work.…”

Section: Animals and Prenatal Methamphetamine Treatmentsupporting

confidence: 48%

“…Pregnant rats were subcutaneously injected once per day (at 1000) with methamphetamine (5 mg·kg Ϫ1 ·day Ϫ1 ) or saline starting at gestational day 1 and continuing throughout the pregnancy. This dose was chosen on the basis of previous work demonstrating that prenatal exposure to methamphetamine (5 mg·kg Ϫ1 ·day Ϫ1 ) alters exploratory behavior, locomotor activity, and memory in adult rats (39,40,41). Pups were weaned at 21 days of age and housed three to four per cage.…”

Section: Animals and Prenatal Methamphetamine Treatmentmentioning

confidence: 99%

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Prenatal methamphetamine differentially alters myocardial sensitivity to ischemic injury in male and female adult hearts

Rorabaugh

Seeley

Bui

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

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Rorabaugh BR, Seeley SL, Bui AD, Sprague L, D'Souza MS. Prenatal methamphetamine differentially alters myocardial sensitivity to ischemic injury in male and female adult hearts. Am J Physiol Heart Circ Physiol 310: H516 -H523, 2016. First published December 18, 2015 doi:10.1152/ajpheart.00642.2015-Methamphetamine is one of the most common illicit drugs abused during pregnancy. The neurological effects of prenatal methamphetamine are well known. However, few studies have investigated the potential effects of prenatal methamphetamine on adult cardiovascular function. Previous work demonstrated that prenatal cocaine exposure increases sensitivity of the adult heart to ischemic injury. Methamphetamine and cocaine have different mechanisms of action, but both drugs exert their effects by increasing dopaminergic and adrenergic receptor stimulation. Thus the goal of this study was to determine whether prenatal methamphetamine also worsens ischemic injury in the adult heart. Pregnant rats were injected with methamphetamine (5 mg·kg Ϫ1 ·day Ϫ1 ) or saline throughout pregnancy. When pups reached 8 wk of age, their hearts were subjected to ischemia and reperfusion by means of a Langendorff isolated heart system. Prenatal methamphetamine had no significant effect on infarct size, preischemic contractile function, or postischemic recovery of contractile function in male hearts. However, methamphetamine-treated female hearts exhibited significantly larger infarcts and significantly elevated enddiastolic pressure during recovery from ischemia. Methamphetamine significantly reduced protein kinase Cε expression and Akt phosphorylation in female hearts but had no effect on these cardioprotective proteins in male hearts. These data indicate that prenatal methamphetamine differentially affects male and female sensitivity to myocardial ischemic injury and alters cardioprotective signaling proteins in the adult heart. prenatal methamphetamine; ischemia; heart; pregnancy; drug abuse NEW & NOTEWORTHY Prenatal exposure to methamphetamine increases myocardial sensitivity to ischemic injury and alters proteins involved in cardioprotective signaling pathways in the adult female rat heart. These changes were not observed in male hearts. The responses of adult male and female hearts to an ischemic insult are differentially altered by prenatal methamphetamine.METHAMPHETAMINE is one of the most common illicit drugs abused during pregnancy (2, 29). One study found that 5.2% of pregnant women use methamphetamine at some point during their pregnancy (2). Most studies of prenatal methamphetamine have focused on the impact of this drug on behavior and cognitive effects during early childhood. Prenatal methamphetamine produces a variety of neurological effects, including structural changes in the brain (8, 37), increased prevalence of cognitive and behavioral problems (11, 23), delayed development of gross motor skills (42), and decreased verbal and spatial memory (8). In contrast to these neurological effects, the impact of prenatal methamphetamin...

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Section: Animals and Prenatal Methamphetamine Treatmentsupporting

confidence: 48%

Section: Animals and Prenatal Methamphetamine Treatmentmentioning

confidence: 99%

Prenatal methamphetamine differentially alters myocardial sensitivity to ischemic injury in male and female adult hearts

Rorabaugh

Seeley

Bui

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

show abstract

“…115 (2014) No. 1-2, p. 43-59 with respect of adult MA challenge affects behaviour in unknown environment (Schutová et al, 2013), learning abilities tested in Morris water maze (Schutová et al, 2008;Macúchová et al, 2013), anxiety-like behaviour in elevated plus-maze and in the open field (Schutová et al, 2009b), pain sensitivity tested in plantar tests (Yamamotová and Šlamberová, 2012) and seizure susceptibility in adult male and female rats Bernášková et al, 2011;Matějovská et al, 2014). Thus, these results suggest that prenatal MA exposure may induce long-term effects that influence the sensitivity to the same drug in adulthood.…”

Section: )mentioning

confidence: 99%

“…Laboras is a fully automatic system for continuous behaviour recognition and tracking in small rodents (for details see Schutová et al, 2013). Challenge dose of AMP (5 mg/ml/kg) or saline (1 ml/kg) was administered immediately prior to placing the animal to the Laboras cage to both of the prenatal exposure groups (prenatally MA-exposed and prenatally saline-exposed).…”

Section: )mentioning

confidence: 99%

Effect of Amphetamine on Adult Male and Female Rats Prenatally Exposed to Methamphetamine

et al. 2014

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Abstract:The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to adult amphetamine (AMP) treatment in male and female rats. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male and female offspring (prenatally MA-or saline-exposed) were administered with AMP (5 mg/kg) or saline (1 ml/kg) in adulthood. Behaviour in unknown environment was examined in open field test (Laboras), active drug-seeking behaviour in conditioned place preference test (CPP), spatial memory in the Morris water maze (MWM), and levels of corticosterone (CORT) were analyzed by enzyme immunoassay (EIA). Our data demonstrate that in Laboras test, AMP treatment in adulthood increased general locomotion (time and distance travelled) regardless of the prenatal exposure and sex, while AMP increased exploratory activity (rearing) only in prenatally MA-exposed animals. AMP induced sensitization only in male rats, but not in females when tested drug-seeking behaviour in the CPP test. In the spatial memory MWM test, AMP worsened the performance only in Prague Medical Report / Vol. 115 (2014) No. 1-2, p. 43-59 females, but not in males. On the other hand, males swam faster after chronic AMP treatment regardless of the prenatal drug exposure. EIA analysis of CORT levels demonstrated higher level in females in all measurement settings. In males, prenatal MA exposure and chronic adult AMP treatment decreased CORT levels. Thus, our data demonstrated that adult AMP treatment affects behaviour of adult rats, their spatial memory and stress response in sex-specific manner. The effect is also influenced by prenatal drug exposure. 44)

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“…Em nosso estudo verificamos que o gênero não interfere no comportamento locomotor. Alguns autores verificaram que roedores fêmeas se locomovem mais que machos em diferentes medidas (BENVENGA et al, 2011;SCHUTOVÁ et al, 2012 WINGFIELD et al, 1990;SAPOLSKI, 1991;OLIVEIRA et al, 1996;STRIER et al, 1999;BROCKMAN et al, 2001, MULLER;WRANGHAM, 2004, SANNEN et al, 2004 (SCHEDLOWSKI et al, 1993b;BROSSCHOT et al, 1994;DHABHAR et al, 1995b;MILLS et al, 1995;BOSCH et al, 2003;STEFANSKI;GRÜNER, 2006 …”

Section: Comparando Gêneros Diferentesunclassified

Relação entre gênero e perfil comportamental de cães e seu sistema imunológico

Akamine¹

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amor, apoio incondicional, por terem me dado todas as oportunidades que nunca tiveram, por deixar que eu traçasse meu caminho, me dando conselhos, mas não impedindo que eu errasse, pois com meus erros aprendi. Todos os passos que dou, penso em como vocês os dariam. Se acertei, foi pelos ensinamentos que me deram; se errei, foi porque ainda não aprendi direito, mas continuo lutando. Espero um dia ter um milésimo da inteligência do meu pai, e a mesma parte da persistência e garra da minha mãe. Somados ao amor e respeito ao próximo que me ensinaram a ter, e ao caráter que me deram, eu terei um futuro brilhante garantido.Ao meu irmão, Cleber Akira Akamine, que me acompanhou de perto em todas as fases. Boas e ruins. Que sempre me apoiou e torceu por mim. Que sempre me fez enxergar a realidade, e a minha realidade, por melhor ou pior que fosse. Pela convivência, ainda que hoje seja rara, fisicamente, saiba que você está sempre em meus pensamentos.Ao meu namorado Bruno Dias Rosa, por todo amor e dedicação. Pela enorme paciência. Por me aceitar como eu sou. Por aguentar os meus momentos ausentes, minhas falhas. Por me fazer feliz, todos os dias.Aos meus grandes amigos, ainda que poucos, ainda que loucos, por todos os momentos felizes. Obrigada por todo carinho e por me ajudarem nessa longa jornada. AGRADECIMENTOSAo Prof. Dr. Frederico Azevedo da Costa Pinto pela orientação neste trabalho. Por me ter aberto as portas da academia. Por ter acreditado em mim. E mesmo que não tenha estado presente fisicamente em todos os momentos, saiba que meu pai também não esteve fisicamente em todos os momentos da minha vida. Nem por isso aprendi menos, ou o amei menos. Sempre o tive, e tenho você, como norte nas minhas decisões. E sei que posso contar com ambos, quando e onde estiverem. Você, assim como ele, me fez caminhar com minhas próprias pernas, e hoje tenho segurança de andar em qualquer terreno. Agradeço também à Carol, por ter tido a idéia de nos apresentar, e por acreditar que eu estava à altura deste lugar, pela sua amizade e ajuda, durante todo esse tempo. À Profa. Dra. Cristina de Oliveira Massoco Salles Gomes pelo apoio, pelos conselhos, e por tornar essa fase mais simples. Por ter contribuído com meu crescimento pessoal e acadêmico.Por ter ajudado tanto nesta reta final, sem você não sei como seria.Ao Prof. Dr. João Palermo Neto por abrir as portas do Grupo de Neuroimunomodulação, e me deixar fazer parte deste grupo de trabalho com pessoas tão capacitadas, por me ensinar cotidianamente, e por ter contribuído com a minha formação.Ao Programa de Pós-Graduação em Patologia Experimental e Comparada, do Departamento de Patologia desta faculdade, por permitirem que esse trabalho fosse realizado e pela estrutura oferecida.Aos funcionários do Departamento de Patologia, técnicos de laboratórios, secretárias, auxiliares gerais, por terem tornado meus dias mais tranquilos e agradáveis, por fazerem seus trabalhos dignamente, para que este departamento funcione da maneira como tem que ser. A todos os colegas da pós-graduação pela conv...

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Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood

Cited by 37 publications

References 46 publications

Prenatal methamphetamine differentially alters myocardial sensitivity to ischemic injury in male and female adult hearts

Prenatal methamphetamine differentially alters myocardial sensitivity to ischemic injury in male and female adult hearts

Effect of Amphetamine on Adult Male and Female Rats Prenatally Exposed to Methamphetamine

Relação entre gênero e perfil comportamental de cães e seu sistema imunológico

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