Gender differences in associations of cognitive impairments with homocysteine in schizophrenia

Zhou, Sumiao; Huang, Yuanyuan; Kuang, Qijie; Yan, Shuicheng; Feng, Yangdong; Li, Hehua; Wu, Kai; Wu, Fengchun; Huang, Xingbing

doi:10.1016/j.ajp.2022.103214

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…IN the present study, we found that (1) FEDN individuals with schizophrenia had higher serum Hcy levels than healthy controls, (2) serum concentrations of Hcy were positively correlated with the PANSS general psychopathology subscale and PANSS total scores for patients, and (3) male patients had significantly higher Hcy levels than female patients. To the best of our knowledge, few studies have reported the sex difference in serum Hcy levels in FEDN individuals with schizophrenia of Chinese ethnicity [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Increased serum homocysteine in first episode and drug-naïve individuals with schizophrenia: sex differences and correlations with clinical symptoms

Yang

et al. 2022

BMC Psychiatry

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Background Accumulating evidence shows that homocysteine (Hcy) is implicated in the pathophysiology of schizophrenia, and plays an important role in clinical characteristics. This study evaluated the relationships between Hcy levels and clinical features in first-episode, Chinese Han, drug-naïve (FEDN) patients with schizophrenia. Methods FEDN individuals (119 with schizophrenia and 81 healthy controls matched for age, sex, education, and body mass index (BMI)) were enrolled. The serum Hcy levels were determined by enzyme cycle assay experiments. Severities of clinical symptoms were rated on the Positive and Negative Syndrome Scale (PANSS). Results FEDN individuals with schizophrenia had higher Hcy levels compared with healthy controls (F = 46.865, P < 0.001). Correlation analysis and multiple stepwise regression analyses showed that serum Hcy levels in FEDN schizophrenia individuals were positively correlated with PANSS general psychopathology subscale (r = 0.294, P = 0.001) and PANSS total score (r = 0.273, P = 0.003). No significant association was found between Hcy and age, BMI, PANSS positive subscale, and the PANSS negative subscale (all, P > 0.05). Male individuals had significantly higher serum Hcy levels than female individuals (F = 7.717, P = 0.006) after controlling for confounding factors (F = 0.759, P = 0.011). Conclusions Serum Hcy levels were increased in FEDN individuals with schizophrenia, and Hcy levels may be involved in pathophysiological mechanisms. Sex differences in Hcy levels were observed, with higher levels in male FEDN individuals compared to females.

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Section: Discussionmentioning

confidence: 99%

Increased serum homocysteine in first episode and drug-naïve individuals with schizophrenia: sex differences and correlations with clinical symptoms

Yang

et al. 2022

BMC Psychiatry

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“…Multiple studies have indicated that OS plays a role in the development of early cognitive impairment in SCZ [22]. We previously established a correlation between OS markers and cognitive function, gender, and obesity in individuals diagnosed with SCZ, setting the stage for additional research on the link between antioxidant levels and cognitive function in patients with SCZ [23,24]. Although previous investigations have con rmed the correlation between cognitive function and OS in patients with SCZ, most were laboratory studies.…”

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confidence: 99%

Association between cognitive function, antioxidants, and clinical variables in Chinese patients with schizophrenia

Li,

Huang,

et al. 2024

Preprint

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Objective Cognitive dysfunction is a prevalent and intricate manifestation of schizophrenia (SCZ) that may be associated with distinct clinical factors and the presence of antioxidants, which relationship is unclear. The study aimed to investigate cognitive function and its influencing factors in Chinese patients with SCZ. Methods A group of 133 patients with SCZ and 120 healthy controls (HCs) were recruited. The MATRICS Consensus Cognitive Battery (MCCB) was utilized to evaluate cognitive ability, and the Positive and Negative Syndrome Scale (PANSS) was used to assess clinical symptoms. Levels of plasma superoxide dismutase (SOD), serum albumin (ALB) and uric acid (UA) were assessed. Results Compared with HCs, patients with SCZ exhibited lower cognitive performance as indicated by MCCB scores, including the dimensions of speed of processing, attention/vigilance, working memory, verbal learning, and visual learning. In the SCZ group, total PANSS scores were negatively associated with all MCCB dimensions (all p < 0.05), except for the attention/vigilance score. The PANSS-negative and PANSS-cognitive subscores were negatively associated with speed of processing, verbal learning, and visual learning scores (all p < 0.05). The PANSS-excited subscores showed a negative correlation with working memory and visual learning scores (all p < 0.05). ALB levels significantly decreased, and their UA and SOD levels were notably elevated compared to HCs (all p < 0.05). ALB levels and PANSS-negative factors were correlated with to speed of processing, working memory, and visual learning dimensions. SOD levels were independent contributors to the attention/vigilance dimension. Conclusions The cognitive function was decreased in SCZ. The degree of cognitive impairment was closely related to ALB, SOD levels and negative clinical symptoms.

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Sulfur-containing amino acids and risk of schizophrenia

Wu,

Ao,

et al. 2023

Schizophrenia Research

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Gender differences in associations of cognitive impairments with homocysteine in schizophrenia

Cited by 3 publications

References 9 publications

Increased serum homocysteine in first episode and drug-naïve individuals with schizophrenia: sex differences and correlations with clinical symptoms

Increased serum homocysteine in first episode and drug-naïve individuals with schizophrenia: sex differences and correlations with clinical symptoms

Association between cognitive function, antioxidants, and clinical variables in Chinese patients with schizophrenia

Sulfur-containing amino acids and risk of schizophrenia

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