Gender differences in albumin and ascorbic acid in the vitreous antioxidant system

Schwab, Christoph; Paar, Margret; Fengler, Vera H.; Ivastinović, Domagoj; Haas, Anton; Seidel, Gerald; Glatz, Wilfried; Malle, Eva-Maria; Weger, Martin; Velikay-Parel, Michaela; Faustmann, Gernot; Wedrich, Andreas; Reibnegger, Gilbert; Winklhofer‐Roob, Brigitte M.; Oettl, Karl

doi:10.1016/j.freeradbiomed.2019.11.008

Cited by 7 publications

(4 citation statements)

References 33 publications

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“…Fourthly, the gender and ethnicity of the patients may influence plasma concentrations of vitamin C and subsequent responsiveness. In this context, studies showed that gender might affect vitamin C tissue distribution and pharmacokinetics [96,97]. Lastly, but not the least, the optimal dosage regimen of vitamin C in treating sepsis remains poorly characterized.…”

Section: Clinical Perspectivesmentioning

confidence: 99%

Vitamin C for sepsis intervention: from redox biochemistry to clinical medicine

Zhu

2021

Mol Cell Biochem

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Vitamin C, also known as ascorbic acid or ascorbate, is a water-soluble vitamin synthesized in plants as well as in animals except humans and several other animal species. Humans obtain vitamin C from dietary sources and via vitamin supplementation. Vitamin C possesses important biological functions, including serving as a cofactor for many enzymes, acting as an antioxidant and anti-inflammatory compound, and participating in regulating stem cell biology and epigenetics. The multifunctional nature of vitamin C contributes to its essentialness in maintaining and safeguarding physiological homeostasis, especially regulation of immunity and inflammatory responses. In this context, vitamin C has been investigated for its efficacy in treating diverse inflammatory disorders, including sepsis, one of the major causes of death globally and for which currently there is no cure. Accordingly, this Mini-Review surveys recent major research findings on the effectiveness of vitamin C and the underling molecular mechanisms in sepsis intervention in both experimental animal models and randomized controlled trials. To set a stage for discussing the effects and mechanisms of vitamin C in sepsis intervention, this Mini-Review begins with an overview of vitamin C redox biochemistry and its multifunctional properties.

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Section: Clinical Perspectivesmentioning

confidence: 99%

Vitamin C for sepsis intervention: from redox biochemistry to clinical medicine

Zhu

2021

Mol Cell Biochem

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“…With respect to blood parameters, plasma albumin concentrations did not differ between males and females [ 20 ] in healthy patients, but they were lower in our women with obesity, and this could be due to pathological obesity. Albumin levels were involved in appetite regulation because they could serve as carrier ligands for molecular substances, such as ghrelin, involved in stimulating appetite [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 71%

Gender and Liver Steatosis Discriminate Different Physiological Patterns in Obese Patients Undergoing Bariatric Surgery: Obesity Center Cohort

Donghia,

Schiano Di Cola,

Cesaro

et al. 2023

Nutrients

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Background: Obesity is a major public health problem worldwide. Bariatric surgery can reduce body weight, and it is one of the better ways to improve metabolic disease and lifestyle. The aim of this study was to explore a new cohort of patients with obesity and evaluate the gender differences and the steatosis status within the gender group. Methods: A cohort of 250 adult obese patients with BMI ≥ 30 and age >18 years, eligible for gastric bariatric surgery at Pineta Grande Hospital, Castel Volturno (Italy) was studied. Results: The prevalence in women was higher (72.40%) than men (27.60%). Overall, results indicated many statistically significant gender differences in hematological and clinical parameters. Analysis of the subcohorts based on the severity of steatosis revealed differences of this condition between the genders. Steatosis was more prevalent in the male subcohort, but female patients revealed greater within-group differences. Conclusions: Many differences were found not only in the total cohort but also between the gender subcohorts, both in the presence and absence of steatosis. We can conclude that the pathophysiological, genetic, and hormonal patterns affecting these patients delineate different individual profiles.

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“…Of note, an article reported that, in schizophrenia patients, women have generally higher cholesterol plasma levels compared to men especially with advancing of age [ 61 ]. Similarly, the plasma levels of albumin resulted to be lower in female patients than male ones although no gender differences are reported in general population [ 62 ]. Albumin has antioxidant properties and current literature shows that patients affected by schizophrenia result to have lower albumin plasma levels than those with other psychotic disorders [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Gender differences in clinical and biochemical parameters among patients hospitalized for schizophrenia: towards precision medicine

Esposito

Cagna

Caldiroli

et al. 2023

Eur Arch Psychiatry Clin Neurosci

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Background The scientific literature shows some gender differences in the clinical course of schizophrenia. The aim of this study is to identify gender differences in clinical and biochemical parameters in subjects affected by schizophrenia. This would allow for the implementation of individualized treatment strategies. Methods We examined a large set of clinical and biochemical parameters. Data were obtained from clinical charts and blood analyses from a sample of 555 schizophrenia patients consecutively admitted for exacerbation of symptoms to the inpatient clinic of Fondazione IRCCS Policlinico (Milan) or ASST Monza in Italy from 2008 to 2021. Univariate analyses, binary logistic regression, and a final logistic regression model were performed with gender as dependent variable. Results The final logistic regression models showed that male patients (compared to females) were more prone to lifetime substance use disorders (p = 0.010). However, they also had higher GAF (global functioning) mean scores (p < 0.001) at the time of hospitalization. Univariate analyses showed that male patients (with respect to females) had an earlier age at onset (p < 0.001), a more frequent family history of multiple psychiatric disorders (p = 0.045), were more often smokers (p < 0.001), had a more frequent comorbidity with at least one psychiatric disorder (p = 0.001), and less often suffered from hypothyroidism (p = 0.011). In addition, men had higher levels of albumin (p < 0.001) and bilirubin (t = 2.139, p = 0.033), but lower levels of total cholesterol (t = 3.755, p < 0.001). Conclusions Our analyses indicate a less severe clinical profile in female patients. This is evident especially in the early years of the disorder, as suggested by less comorbidity with psychiatric disorders or later age at onset; this is consistent with the related literature. In contrast, female patients seem to be more vulnerable to metabolic alterations as demonstrated by more frequent hypercholesterolemia and thyroid dysfunction. Further studies are needed to confirm these results in the framework of precision medicine.

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Gender differences in albumin and ascorbic acid in the vitreous antioxidant system

Cited by 7 publications

References 33 publications

Vitamin C for sepsis intervention: from redox biochemistry to clinical medicine

Vitamin C for sepsis intervention: from redox biochemistry to clinical medicine

Gender and Liver Steatosis Discriminate Different Physiological Patterns in Obese Patients Undergoing Bariatric Surgery: Obesity Center Cohort

Gender differences in clinical and biochemical parameters among patients hospitalized for schizophrenia: towards precision medicine

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