Gender Differences in Age-Stratified Early Outcomes in Patients With Transcatheter Aortic Valve Implantation

Zhou, Chi; Xia, Zongyi; Chen, Bing; Song, Yanxu; Lian, Zhexun

doi:10.1016/j.amjcard.2022.10.038

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Other subgroups of patients in which women had an increased mortality were very elderly, frail patients as well as those with pulmonary hypertension ( 21 , 42 ). The longer waiting times for TAVI observed in women were also associated with higher rates of mortality and hospitalizations for heart failure and reduced mobility ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Sex discrepancies in pathophysiology, presentation, treatment, and outcomes of severe aortic stenosis

Stehli,

Zaman,

Stähli

2023

Front. Cardiovasc. Med.

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This review gives an overview of sex-based differences in aortic valve stenosis, spanning from pathophysiological mechanisms and disease progression, clinical presentation, presence of comorbidities, and diagnostic assessment, to treatment and outcomes. In particular, sex-related differences in the degree of aortic valve calcification, the response of the left ventricle to pressure overload, as well as in the referral to procedures, with women being less frequently referred for surgical aortic valve replacement and experiencing longer waiting times for transcatheter procedures, will be discussed. Sex-related differences are also particularly evident in outcomes of patients with severe aortic stenosis undergoing surgical or transcatheter procedures. The apparent sex paradox seen in women undergoing transcatheter aortic valve implantation refers to the phenomenon of women experiencing higher rates of short-term mortality and bleeding events, but demonstrating improved long-term survival as compared to men. Women who undergo surgical aortic valve replacement have generally worse outcomes as compared to men, which is reflected by the inclusion of female sex in surgical risk calculation scores. Hence, a thorough understanding of sex-related differences in aortic valve stenosis is important to provide optimal and personalized patient care.

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Section: Introductionmentioning

confidence: 99%

Sex discrepancies in pathophysiology, presentation, treatment, and outcomes of severe aortic stenosis

Stehli,

Zaman,

Stähli

2023

Front. Cardiovasc. Med.

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Gender Disparities in Valvular Heart Disease and Treatment in the Aging Population

Desmarais,

Dichiacchio,

Fanous

et al. 2024

Curr Geri Rep

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Percutaneous pulmonary valve implantation in children and adults with an age and gender-specific analysis

Kotidis,

Nirmal,

Kantzis

2024

Cardiol Young

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Background: There are limited studies with medium-term follow-up following percutaneous pulmonary valve implantation and no studies with a gender-specific analysis. Aims: To report clinical outcomes up to five years following percutaneous pulmonary valve implantation using the two most common balloon expandable valves in a mixed population of paediatric and adult patients with an age and gender-specific analysis. Methods: This was a single-centre retrospective observation study. Relevant data were obtained retrospectively from the case files. Age and gender- specific analysis was performed using SPSS. Results: Totally, 58 patients (13 children, 45 adults) underwent percutaneous pulmonary valve implantation. Statistically significant reduction in median right ventricular outflow tract flow velocity following valve implantation was maintained for the whole five years in adults but not in children. There were no gender-specific differences despite the study being adequately powered. Independent of valve type used, there was significant reduction of the right ventricular outflow tract flow velocity in the immediate post valve implantation period (Edwards P = 0.001, Melody P = 0.013). There was a significant negative correlation between implanted valve Z-score and subsequent right ventricular outflow tract gradient during the first two years following valve implantation. Conclusion: Gender does not significantly affect valve function following percutaneous pulmonary valve implantation. It is important to consider patients’ age and body surface area in relation to existing right ventricular outflow tract size during decisions for percutaneous pulmonary valve implantation.

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Gender Differences in Age-Stratified Early Outcomes in Patients With Transcatheter Aortic Valve Implantation

Cited by 4 publications

References 33 publications

Sex discrepancies in pathophysiology, presentation, treatment, and outcomes of severe aortic stenosis

Sex discrepancies in pathophysiology, presentation, treatment, and outcomes of severe aortic stenosis

Gender Disparities in Valvular Heart Disease and Treatment in the Aging Population

Percutaneous pulmonary valve implantation in children and adults with an age and gender-specific analysis

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