Gender difference of serum angiotensin-converting enzyme (ACE) activity in DD genotype of ACE insertion/deletion polymorphism in elderly Chinese

Abstract

Introduction: In this study we investigated the gender difference of serum angiotensin-converting enzyme (ACE) activity in a population of Hong Kong-dwelling elderly Chinese. Materials and methods: A total of 1767 (843 male, 924 female) Hong Kong-dwelling elderly Chinese were recruited. ACE I/D genotypes were identified by polymerase chain reaction amplification and serum ACE activity was determined using a commercially available kinetic kit. ACE I/D genotype distribution was compared by chi-square test, the correlation between ACE I/D polymorphism and serum ACE activity was analysed by ANOVA test and gender difference of serum ACE activity of different genotypes was compared by independent sample t-test. Results: No statistically significant difference of genotype distribution between male and female subjects was found. Serum ACE activity was significantly correlated with ACE genotype. Overall, there was no gender difference of serum ACE activity; however, when sub-grouping the subjects by ACE I/D genotype, male subjects with DD genotype had higher serum ACE activity than female subjects with DD genotype. Conclusions: No significant gender difference of genotype distribution was found in elderly Chinese. Serum ACE activity was significantly correlated with ACE I/D polymorphism in elderly Chinese. Male subjects with DD genotype had higher serum ACE activity than female subjects with DD genotype.

Effects of eNOS rs1799983 and ACE rs4646994 polymorphisms on the therapeutic efficacy of salvianolate injection in Chinese patients with coronary heart disease

“…There is an association between ACE gene polymorphism and the occurrence of CHD because the ACE D allele mutation results in higher ACE levels around blood vessels, generating more AngII and less bradykinin, leading to reductions in NO and prostacyclin. Other studies have confirmed this . Together, all these observations may explain, in part, the results regarding the therapeutic efficacy of salvianolate in the present study.…”

Genetic variants in rheumatic fever and rheumatic heart disease

“…Angiotensin I converting enzyme (ACE) is a zinc metallopeptidase, which suggest that ACE could be involved in different physiological processes. The ACE serum level can be influenced by genetic factors (Zhang et al, ). The ACE I/D SNP has been significantly associated with serum ACE activity (Zhang et al, ).…”

“…The ACE serum level can be influenced by genetic factors (Zhang et al, ). The ACE I/D SNP has been significantly associated with serum ACE activity (Zhang et al, ). The ACE gene (I/D) was recently reviewed by Tian et al, consistent with HuGENet™ review study design and recommendations (Tian et al, ).…”

The angiotensin converting enzyme (ace) gene polymorphism: Insight study of the renal regulation of the arterial blood pressure

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“…Some studies point to the gender-dependent effect of ACE I/D polymorphism on blood ACE levels (20,21,22). Zhang et al suggested that in Asian population differences in blood ACE levels between DD genotype and other genotypes were more pronounced in men than in women (21). Contrary, a study conducted by Biller and associates on Caucasian population reported the opposite results (22).…”