Gender Difference in the Relationships between Inflammatory Markers, Serum Uric Acid and Framingham Risk Score

Huang, Jui-Hua; Li, Ren-Hau; Huang, Shu-Wei; Sia, Hon-Ke; Yu, Chao-Hung; Tang, Feng-Cheng

doi:10.3390/ijerph18137103

Cited by 4 publications

(4 citation statements)

References 49 publications

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“…In addition, vascular parameters are usually higher in males than in females [ 31 ]. Due to a gender difference in the relationship between sUA and Framingham Risk Score, sUA can only be used as marker of risk of future CVD events in males [ 32 ]. Gender differences in CVD pathophysiology, clinical presentation, prevention, and management have also been observed [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Serum Uric Acid and Exercise Capacity in Older Adults Hospitalized for Worsening Cardiovascular Disease

Hirashiki,

Shimizu,

Kamihara

et al. 2024

JCDD

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Elevated serum uric acid (sUA) is associated with the risk of developing cardiovascular disease (CVD). Here, we examined the prognostic significance of sUA and exercise capacity in 411 Japanese adults (age, ≥65; mean, 81 years) hospitalized for worsening CVD. When the patients were stratified by sUA into three groups (<5.3, 5.4–6.9, >7.0 mg/dL), the high-sUA group had a significantly worse peak VO2 and composite endpoint (rehospitalization due to worsening CVD and all-cause mortality) compared with low- and moderate-sUA groups (p < 0.001). When the patients were stratified by sUA into five groups (sUA < 3.9, 4.0–5.9, 6.0–7.9, 8.0–8.9, and >10.0 mg/dL), the incidence of the composite endpoint was significantly higher in the highest sUA group compared with that in the reference group, but only in women. Univariate Cox regression analysis, but not a multivariate analysis, indicated that sUA was significantly associated with the composite endpoint. Although sUA and exercise capacity may have some degree of prognostic significance in older patients with CVD, this significance may differ between men and women.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Serum Uric Acid and Exercise Capacity in Older Adults Hospitalized for Worsening Cardiovascular Disease

Hirashiki,

Shimizu,

Kamihara

et al. 2024

JCDD

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“…Age is one of the important phenomenological variables in determining and evaluating life, this will determine how a person will behave [17]. The age range of 60-65 years has a mature personality so that it can take precautions related to increased uric acid levels [18].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Attitude and Preventive Behavior of Increased Uric Acid Levels in the Elderly

Yuswatiningsih¹,

Maunaturrohmah²

2022

Babali Nurs. Res.

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Introduction: The increase in the number and life expectancy of the elderly causes problems and various needs of the elderly. Increasing age makes physiological functions decrease due to degenerative processes (aging). One of the diseases experienced by the elderly is gout. The purpose of this study was to analyze the relationship between attitudes and behavior to prevent increased uric acid levels in the elderly. Methods: The design of this research is analytic with a cross-sectional approach. The population in this study were all the elderly in Ngudirejo Village, Diwek District, Jombang Regency as many as 120 elderly and the number of samples was 92 respondents using a simple random sampling technique. Collecting data using a questionnaire about attitudes and behavior to prevent an increase in uric acid. Data processing by editing, coding, scoring, tabulating, and analysis using the Spearman Rank Correlation statistical test with an alpha of 0.05. Results: The results showed that the attitudes of the elderly were positive as many as 62 respondents (67%) and negative as many as 30 respondents (33%), while for the prevention behavior of increasing uric acid levels both 29 respondents (32%), enough were 42 respondents (46%) and less as many as 21 respondents (22%). The results of the analysis test showed that the value of p = 0.000 was smaller than the alpha value of 0.05 so the alternative hypothesis was accepted. Conclusion: The conclusion in this study is that there is a relationship between attitudes and behavior to prevent an increase in uric acid levels in the elderly. The results of this study imply the importance of attitudes and behavior in preventing an increase in uric acid levels in the elderly.

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“…In addition, vascular parameters are usually higher in males than in females [34]. Due to a gender difference in the relationship between sUA and Framingham Risk Score, sUA can be used as marker of risk of future CVD events in males only [35]. Gender differences in CVD pathophysiology, clinical presentation, prevention, and management have also been observed [36,37].…”

Section: Gender Differencesmentioning

confidence: 99%

Prognostic Significance of Serum Uric Acid and Exercise Capacity in Older Adults Hospitalized for Worsening Cardiovascular Disease

MD,

Shimizu,

Kamimura

et al. 2024

Preprint

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Elevated serum uric acid (sUA) is associated with risk of developing cardiovascular disease (CVD). Here, we examined the prognostic significance of sUA and exercise capacity in 411 Japanese adults (age, ≥65; mean, 81 years) hospitalized for worsening CVD. Mean sUA was significantly higher in the 23% of patients on an sUA-lowering agent than in those not. When the patients were stratified by sUA into three groups (7.0 mg/dL), the high sUA group had significantly worse peak VO2 and composite endpoint (rehospitalization due to worsening CVD and all-cause mortality) compared with low and moderate sUA groups (P < 0.001). When the patients were stratified by sUA into five groups (sUA 10.0 mg/dL), the incidence of the composite endpoint was significantly higher in the highest sUA group compared with that in the reference group, but only in women. Univariate Cox regression analysis, but not a multivariate analysis, indicated that sUA was significantly associated with the composite endpoint. Although sUA and exercise capacity may have some degree of prognostic significance in older patients with CVD, this significance may differ between men and women.

show abstract

Gender Difference in the Relationships between Inflammatory Markers, Serum Uric Acid and Framingham Risk Score

Cited by 4 publications

References 49 publications

Prognostic Significance of Serum Uric Acid and Exercise Capacity in Older Adults Hospitalized for Worsening Cardiovascular Disease

Prognostic Significance of Serum Uric Acid and Exercise Capacity in Older Adults Hospitalized for Worsening Cardiovascular Disease

Relationship between Attitude and Preventive Behavior of Increased Uric Acid Levels in the Elderly

Prognostic Significance of Serum Uric Acid and Exercise Capacity in Older Adults Hospitalized for Worsening Cardiovascular Disease

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