Gender difference in the relationship between the ferritin and homeostasis model assessment of insulin resistance in non-diabetic Korean adults

Yoon, Hyun Ju; Kim, Yoon Sik; Lee, Jun Ho; Gi, Mi Young; Ae, Ju; Seong, Jeong-Min

doi:10.1371/journal.pone.0199465

Cited by 3 publications

(2 citation statements)

References 41 publications

(34 reference statements)

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“…High serum ferritin levels increased the risk of moderate/severe periodontitis, and, together with transferrin saturation, increased the risk for higher proportion of sites with CAL ≥4 mm in PM women. This association could be confounded by the higher iron level effects on systemic bone metabolism (Kim et al, 2013), or by insulin resistance and diabetes (Zhao et al, 2012;Yoon et al, 2018) since these factors have been consistently associated with periodontitis (Chapple & Genco, 2013;Penoni et al, 2017). However, the association found by this study was independent of the progressive adjustment for age, years of education, PI, smoking, alcohol, obesity, oestrogen replacement, vitamin D deficiency, low bone mineral density, insulin resistance, and C-reactive protein.…”

Section: Discussionmentioning

confidence: 64%

High serum iron markers are associated with periodontitis in post‐menopausal women: A population‐based study (NHANES III)

Costa

Ribeiro

Moreira

et al. 2021

J Clinic Periodontology

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Aim: To investigate the association between increased serum markers of iron (ferritin and transferrin saturation) and the severity and extent of periodontitis in postmenopausal (PM) women.Materials and Methods: Data from 982 PM women participating in NHANES III were analysed. Exposures were high ferritin (≥300 μg/ml) and transferrin saturation (≥45%). The primary outcome was moderate/severe periodontitis defined according to Centers for Disease Control and Prevention and the American Academy of Periodontology. The extent of periodontitis was also assessed as outcome: proportion of sites affected by clinical attachment loss ≥4 mm and probing depth ≥4 mm. Crude and adjusted prevalence ratio (PR) and mean ratio (MR) were estimated using Poisson regression. Results:The prevalence of moderate/severe periodontitis was 27.56%. High ferritin was associated with moderate/severe periodontitis in the crude (PR 1.55, p = .018) and in the final adjusted model (PR 1.53, p = .008). High ferritin and transferrin saturation levels were associated with a higher proportion of sites with clinical attachment loss ≥4 mm (p < .05). Conclusions:The increasing serum iron markers seem to contribute to periodontitis severity and extent in PM women.

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Section: Discussionmentioning

confidence: 64%

High serum iron markers are associated with periodontitis in post‐menopausal women: A population‐based study (NHANES III)

Costa

Ribeiro

Moreira

et al. 2021

J Clinic Periodontology

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“…In a recent meta-analysis, it has been shown that serum ferritin concentration is connected with fasting plasma glucose, serum insulin concentration (17), and plasma triglycerides (TG) level (18). Additionally, studies revealed that serum ferritin levels are connected with homeostasis model assessment of insulin resistance (HOMA-IR) in a non-diabetic population but not in patients with impaired glucose tolerance (19)(20)(21)(22). Therefore, serum ferritin has been proposed as an early marker of insulin resistance (21).…”

Section: Introductionmentioning

confidence: 99%

The Association Between Serum Ferritin Concentration and Visceral Adiposity Estimated by Whole-Body DXA Scan in Women With Polycystic Ovary Syndrome

et al. 2020

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Objective: Women with polycystic ovary syndrome (PCOS) are characterized by insulin resistance and higher prevalence of obesity. Serum ferritin is increased in obesity and is associated with insulin resistance. The aim of the present study was to evaluate the relationships between serum ferritin concentration with insulin resistance and body composition estimated by dual-energy X-ray absorptiometry (DXA) in PCOS women in comparison to the control group. Patients and Methods: One hundred four women were enrolled to the study−65 women with PCOS and 39 women matched for age and BMI as a control group. Serum ferritin concentration and oral glucose tolerance test (OGTT) were performed. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. DXA was performed to estimate fat, fat-free mass, and visceral adipose tissue (VAT). Results: Women with PCOS have higher serum concentration of ferritin (p = 0.002), insulin at baseline (p = 0.03), at 60 min of OGTT (p = 0.01), at 120 min of OGTT (p = 0.004), HOMA-IR (p = 0.03), and VAT (p = 0.0001) in comparison to the control group. We observed a relationship of serum ferritin with insulin concentration at baseline (r = 0.25, p = 0.04) and at 120 min of OGTT (r = 0.31, p = 0.01) and with HOMA-IR (r = 0.30, p = 0.01) in the PCOS group. We noticed an association between serum ferritin concentration and VAT (r = 0.42, p = 0.001), trunk fat mass (r = 0.25, p = 0.04), and android fat mass (r = 0.25, p = 0.04) in the PCOS group. Multiple regression analysis revealed that ferritin (p = 0.02, β = 0.17), insulin at baseline (p = 0.001, β = 0.30), glucose at the 120 min of OGTT (p = 0.007, β = 0.26), and triglycerides (p = 0.001, β = 0.33) were independent predictors of VAT amount in PCOS women. Conclusions: Elevated serum ferritin concentration is connected with insulin resistance as well as with DXA-estimated VAT, android, and trunk fat mass in PCOS women, and could be a marker of metabolic dysfunction.

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Sex Differences in the Effect of Testosterone on Adipose Tissue Insulin Resistance From Overweight to Obese Adults

Liu

Zhou

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

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Objective Adipose tissue distribution and glucose metabolism differ between men and women. Few studies have investigated sex differences in adipose tissue insulin resistance (adipose-IR). Herein, we investigated sex differences in adipose-IR in adults ranging from overweight to obese and the potential factors associated with sex differences in adipose-IR. Methods A total of 424 adults had their BMI, adipose-IR, and sex hormones evaluated. Based on BMI, males and females were assigned to four groups. Results In total, males (n=156) had higher adipose-IR than females with similar BMIs (n=268) (p<0.05). Adipose-IR progressively increased from overweight to class III obesity in both males and females (all p<0.0001); however, only in the class III obesity group was the adipose-IR significantly higher in males than in females (p=0.025). There were significant differences in testosterone between males and females (all p<0.01); testosterone levels were negatively correlated with adipose-IR (r=-0.333, p<0.001) in males but positively correlated with adipose-IR (r=0.216, p<0.001) in females. For the logistic regression analysis, testosterone was an independent protective factor against adipose-IR in males, with an odds ratio of 0.858 (B= -0.153 [95% CI 0.743-0.991], p=0.037). Conclusions Adipose-IR reflects the progressive deterioration in adipose tissue insulin sensitivity from overweight to obesity in both males and females. Males with class III obesity have more severe adipose-IR than similarly obese females. The sex difference is associated with testosterone, and low testosterone levels may contribute to more severe adipose-IR in obese males.

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Gender difference in the relationship between the ferritin and homeostasis model assessment of insulin resistance in non-diabetic Korean adults

Cited by 3 publications

References 41 publications

High serum iron markers are associated with periodontitis in post‐menopausal women: A population‐based study (NHANES III)

High serum iron markers are associated with periodontitis in post‐menopausal women: A population‐based study (NHANES III)

The Association Between Serum Ferritin Concentration and Visceral Adiposity Estimated by Whole-Body DXA Scan in Women With Polycystic Ovary Syndrome

Sex Differences in the Effect of Testosterone on Adipose Tissue Insulin Resistance From Overweight to Obese Adults

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