Gender Difference in the Association Between Serum Uric Acid Level and Metabolic Syndrome and Components: A Cross-Sectional Analysis among Chinese Young Adults

Abstract

Background: This study aimed to investigate the associations between serum uric acid (SUA) levels and metabolic syndrome (MetS) and MetS components in Chinese young adults. Methods: A cross-sectional survey was conducted among 3044 young adults (1266 men and 1778 women). The anthropometric index, lipid profile, fasting blood glucose and SUA levels were measured. Male and female participants were grouped according to the quartiles of SUA level separately. Multiple logistic regression analyses were performed to evaluate the association of SUA quartiles with MetS and its components. Results: The overall prevalence of hyperuricemia and MetS was 29.7% and 2%, respectively. Multiple logistic regression analysis revealed that compared with the lowest 2 quartiles of SUA together, the highest quartile showed an association with the prevalence of MetS and high triglyceride in males, and OR (95% CI) were 3.438(1.090-10.841) and 4.364(2.133-8.930) respectively after adjustments confounding factors. In terms of abdominal obesity, compared with the lowest 2 quartiles of SUA together, the OR (95% CI) was 1.976(1.128-3.459) for those in the third quartile and 1.766(1.020-3.057) for those in the highest quartile after adjustments confounding factors in females. Conclusions: This study suggested a significant positive relationship between SUA and MetS and its components among young adults. Hence, routine measurement of SUA is recommended to prevent hyperuricemia and its related complications.