Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults

Seong, Jeong-Min; Yoon, Yo Sang; Lee, Kyu Su; Bae, Nan Young; Gi, Mi Young; Yoon, Hyun Ju

doi:10.1371/journal.pone.0177722

Cited by 20 publications

(23 citation statements)

References 48 publications

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“…Our cohort consisted of mostly middle aged Asians with higher socioeconomic and education levels and urban habitation with the highest annual PM concentrations in the world. Thus, these characteristics can contribute to more increase in the amount of mobilized iron especially in men than women in our cohort [8,[21][22][23][24][25][26]. The large difference in serum ferritin level between men and women can contribute to much higher lifetime iron stores in men than in women.…”

Section: Study Design and Populationmentioning

confidence: 82%

Decreased lung function is associated with elevated ferritin but not iron or transferrin saturation in 42,927 healthy Korean men: A cross-sectional study

et al. 2020

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Objectives Though elevated ferritin level and decreased lung function both predispose people to cardio-metabolic disease, few reports have investigated the association between them. Furthermore, it remains unclear whether the association reflects a change in iron stores or an epiphenomenon reflecting metabolic stress. Therefore, we looked for possible associations between ferritin, iron, and transferrin saturation (TSAT) and lung function to clarify the role of iron-related parameters in healthy men. Methods We conducted a cohort study of 42,927 healthy Korean men (mean age: 38.6 years). Percent predicted forced expiratory volume in one second (FEV1%) and forced vital capacity (FVC%) were categorized into quartiles. Adjusted odds ratios (aORs) and 95% confidence intervals (using the highest quartile as reference) were calculated for hyperferritinemia, high iron, and high TSAT after controlling for potential confounders. Results The median ferritin level was 199.8 (141.5-275.6) ng/mL. The prevalence of hyperferritinemia (defined as >300 ng/mL) was 19.3%. Subjects with hyperferritinemia had lower FEV1% and FVC% than those with normal ferritin level with a slight difference, but those were statistically significant (99.22% vs.99.61% for FEV1%, p = 0.015 and 98.43% vs. 98.87% for

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Section: Study Design and Populationmentioning

confidence: 82%

Decreased lung function is associated with elevated ferritin but not iron or transferrin saturation in 42,927 healthy Korean men: A cross-sectional study

et al. 2020

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“…None of the above studies had considered potential confounders in the association of vitamin D with SF. A recent analysis of the Korea National Health and Nutrition Survey did consider confounders and reported an inverse association between serum 25(OH)D and SF among Korean men [29]. The authors also reported this association for premenopausal women [29] and for women without metabolic syndrome [28], but not for post-menopausal women [29] and women with metabolic syndrome [28].…”

Section: Discussionmentioning

confidence: 99%

“…A recent analysis of the Korea National Health and Nutrition Survey did consider confounders and reported an inverse association between serum 25(OH)D and SF among Korean men [29]. The authors also reported this association for premenopausal women [29] and for women without metabolic syndrome [28], but not for post-menopausal women [29] and women with metabolic syndrome [28]. The latter, to some extent, seems consistent with the observation of the present study that an association between vitamin D and SF was observed among under/normal weight Canadians, but not among those with overweight and obesity.…”

Section: Discussionmentioning

confidence: 99%

“…While our study found an inverse association between serum 25(OH)D and elevated SF among Canadians, a causal relationship cannot be established due to cross-sectional nature of the CHMS. Whereas we considered various confounders, and more so that other studies did, we may not exclude the role of additional confounding factors such as dietary factors, menopausal status, genetic mutations or unknown causes [14, 29, 45, 73], because this information was not available or because our statistical models could not accommodate more confounders. Caution is therefore warranted when interpreting the results.…”

Section: Discussionmentioning

confidence: 99%

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The association of serum 25-hydroxyvitamin D concentrations with elevated serum ferritin levels in normal weight, overweight and obese Canadians

Munasinghe¹,

Ekwaru²,

Mastroeni³

et al. 2019

PLoS ONE

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In light of the growing body of literature suggesting a beneficial effect of vitamin D on inflammatory response, we hypothesized that vitamin D affects serum ferritin (SF), a biomarker of inflammation. The objective of the present study is to examine the association of serum 25-hydroxyvitamin D [25(OH)D] with elevated SF concentrations indicative of inflammation as no earlier study has done so. Data from 5550 Canadian adults who participated in the 2012/2013 and the 2014/2015 Canadian Health Measures Surveys were analysed. We observed that 9.4% of Canadian adults have elevated SF concentrations and that 35.6% were vitamin D insufficient. Among Canadians with under/normal body weights, those with serum 25(OH)D ≥ 75 nmol/L relative to those with serum 25(OH)D < 50 nmol/L, were substantially less at risk for elevated SF concentrations (OR = 0.24; 95% CI = 0.06, 0.89; p = 0.034). We did not observe this association for overweight and obese Canadians. Canadians of older age, non-white ethnicity, males, those with income above $100,000, those who consumed alcohol, and those with high total cholesterol concentrations and elevated blood pressures were more likely to have elevated SF concentrations. Serum 25(OH)D ≥ 75 nmol/L is likely to provoke anti-inflammatory benefits, but intervention studies that achieve high 25(OH)D concentrations and with long follow up are needed to establish the role of vitamin D on SF.

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“…However, the potential influence of vitamin D on SF concentrations, as an inflammation marker, has received relatively little attention. Conclusions from existing and mostly cross-sectional studies are inconsistent [2,17,18,19,20,21,22,23]. Therefore, the objective of this study is to shed more light on the cross-sectional associations of serum 25-hydroxyvitamin D (25(OH)D) with SF concentrations, and, importantly, to examine whether temporal increases in serum 25(OH)D concentrations are paralleled by the reduction in the SF concentrations.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Serum 25-Hydroxyvitamin D on Serum Ferritin Concentrations: A Longitudinal Study of Participants of a Preventive Health Program

et al. 2019

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Various studies have suggested a role of vitamin D in inflammation. However, its effect on ferritin, a biomarker of inflammation, has received relatively little attention. Therefore, we aimed to assess the association of serum 25-hydroxyvitamin D (25(OH)D) with serum ferritin (SF) concentrations, and to examine whether temporal increases in serum 25(OH)D concentrations are paralleled by a reduction in SF concentrations. Data from a community sample of Canadian adults who participated in a preventive health program (n = 6812) were analyzed. During the follow-up, serum 25(OH)D concentrations increased from 80.7 to 115.0 nmol/L whereas SF concentrations decreased from 122.0 to 92.0 µg/L (median follow-up time was 11.67 months). Cross-sectional analyses revealed that compared to participants with 25(OH)D concentrations of <50 nmol/L, those with 25(OH)D concentrations of 75 to <100, 100 to <125, and ≥125 nmol/L had SF concentrations that were 13.00, 23.15, and 27.59 µg/L lower respectively (p < 0.001). Compared to those without temporal improvements in 25(OH)D concentrations between baseline and follow-up, participants who improved their 25(OH)D concentrations with ≥50 nmol/L decreased their SF concentrations with 5.71 µg/L. For participants for whom the increase in 25(OH)D concentrations was less than 50 nmol/L, decreases in SF concentrations were less pronounced and not statistically significant. These observations suggest that despite strong associations between 25(OH)D and SF concentrations, interventions aiming to lower SF concentrations through sun-exposure and vitamin D supplementation should target substantial increases in 25(OH)D concentrations.

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Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults

Cited by 20 publications

References 48 publications

Decreased lung function is associated with elevated ferritin but not iron or transferrin saturation in 42,927 healthy Korean men: A cross-sectional study

Decreased lung function is associated with elevated ferritin but not iron or transferrin saturation in 42,927 healthy Korean men: A cross-sectional study

The association of serum 25-hydroxyvitamin D concentrations with elevated serum ferritin levels in normal weight, overweight and obese Canadians

The Effect of Serum 25-Hydroxyvitamin D on Serum Ferritin Concentrations: A Longitudinal Study of Participants of a Preventive Health Program

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