Gender Difference in Intraocular Pressure and Incidence of Metabolic Syndrome: A Community-Based Cohort Study in Matsu, Taiwan

Kuo, Raymond Nien-Chen; Yang, Chia Ching; Yen, Amy Ming Fang; Liu, Tzeng Ying; Lin, Ming; Chen, Sam Li Sheng

doi:10.1089/met.2018.0131

Cited by 8 publications

(11 citation statements)

References 13 publications

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“…IOP can be influenced by many systemic conditions, including blood pressure [ 26 , 27 ], fasting glucose [ 28 ], atherosclerotic diseases [ 26 ], chronic kidney disease [ 29 ], and thyroid hormone [ 21 ]. In addition, previous studies also discovered a gender difference of IOP in various populations [ 15 , 16 , 17 , 18 ]. In our study, the risk of high IOP was significantly associated with the higher tertiles of serum total calcium levels in the female population.…”

Section: Discussionmentioning

confidence: 89%

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Serum Calcium Level as a Useful Surrogate for Risk of Elevated Intraocular Pressure

Chang

Chen

Tai

et al. 2021

JCM

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Background: Uncontrolled intraocular pressure (IOP) plays a principal role in the deterioration of glaucoma, and the intraocular pressure is also accepted as the most important modifiable factor. Calcium ion has been found to play a vital role in regulating the resistance of the trabecular meshwork in humans. However, the relationship between serum total calcium and IOP has not been well-established. Methods: We investigated the association between serum total calcium and the IOP in a large population (14,037 eligible participants, consisting of 7712 men and 6325 women, were included) at the Tri-Service General Hospital from 2010 to 2016. Several models of covariate adjustments associated with IOP were designed. Univariate and multivariate regression analysis was performed for gender differences in the association between the serum total calcium level and IOP. Results: There was a significant relationship between serum total calcium levels and IOP in women and men with a β coefficient of 0.050 (95% confidence interval (CI), 0.030–0.069) and 0.025 (95%CI, 0.007–0.043). Notably, participants in the highest tertiles of serum total calcium levels had significantly higher IOP, in both the male and female participants. Conclusions: Our study shows that IOP is significantly associated with serum total calcium levels in a large Asian population. This study supports the notion that serum total calcium may play an important role in groups at high risk for elevated IOP.

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Section: Discussionmentioning

confidence: 89%

“…Gender difference in IOP was found in many studies. Some studies revealed the IOP was higher in the male group than in the female group [ 15 , 16 ]. However, some studies proposed the opposite view [ 17 , 18 ].…”

Section: Methodsmentioning

confidence: 99%

Serum Calcium Level as a Useful Surrogate for Risk of Elevated Intraocular Pressure

Chang

Chen

Tai

et al. 2021

JCM

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“…Gender differences in insomnia and related health issues have been widely examined (23)(24)(25)(26)(27). Such differences are not only associated with the etiological and pathophysiological processes, but also associated with the treatments and prognosis of insomnia (24).…”

Section: Introductionmentioning

confidence: 99%

Gender Difference in the Prevalence of Insomnia: A Meta-Analysis of Observational Studies

et al. 2020

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Objective: Insomnia is a major health challenge in the general population, but the results of the gender differences in the epidemiology of insomnia have been mixed. This is a meta-analysis to examine the gender difference in the prevalence of insomnia among the general population.Methods:Two reviewers independently searched relevant publications in PubMed, EMBASE, PsycINFO, Web of Science from their inception to 16 April 2019. Studies that reported the gender-based prevalence of insomnia according to the international diagnostic criteria were included for analyses using the random-effects model.Results:Eventually 13 articles were included in the meta-analysis. The pooled prevalence of insomnia in the general population was 22.0% [n = 22,980, 95% confidence interval (CI): 17.0–28.0%], and females had a significantly higher prevalence of insomnia compared with males (OR = 1.58, 95% CI: 1.35, 1.85, Z = 5.63, p < 0.0001). Subgroup analyses showed that greater gender difference was associated with the use of case-control study design and consecutive sampling method. Meta-regression analyses also revealed that higher proportion of females and better study quality were significantly associated with greater gender difference.Conclusions:This meta-analysis found that the prevalence of insomnia in females was significantly higher than males in the included studies. Due to the negative effects of insomnia on health, regular screening, and effective interventions should be implemented in the general population particularly for females.

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“…However, the same is difficult to achieve because of substantial heterogeneity across the studies in terms of criteria used for diagnoses of metabolic syndrome, the methods of sample selection and different units used for reporting incidence rates. Nevertheless, from Western Pacific region, the reported incidence rates for metabolic syndrome using NCEP ATP III criteria from East China, Japan and South Korea are 37.7, 22 and 40.9 per 1000 person years, respectively [ 19 – 21 ]. These rates are similar to the current study and reflect Asian being the predominant ethnicity in all these countries.…”

Section: Discussionmentioning

confidence: 99%

Incidence and predictors of metabolic syndrome in Asian-Indians: a 10-year population-based prospective cohort study

Jayant

Gupta

Rastogi

et al. 2023

Int J Diabetes Dev Ctries

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Background Metabolic syndrome represents aggregation of risk factors associated with an increased risk of developing type 2 diabetes mellitus (DM) and atherosclerotic cardiovascular disease (ASCVD). Assessing its incidence is an effective way for estimating the future burden of DM and ASCVD and understanding their secular trends and effect of public health measures on halting the evolution of risk factors. The present study aimed to estimate the incidence of metabolic syndrome and its predictors using a population-based cohort. Methods A subset of Chandigarh Urban Diabetes Study cohort ( n = 1023) without diabetes or metabolic syndrome was prospectively evaluated after a mean of 10.7 years. Metabolic syndrome was defined as per International Diabetes Federation criteria and diabetes as per American Diabetes Association standards. The incidence was calculated in 1000 person years, and multivariate logistic regression was used to estimate the strength of association between incident metabolic syndrome and risk factors. Results In the followed-up individuals ( n = 303), incidence of metabolic syndrome was 32.1 per 1000 person years (95% CI 26.3–38.7 per 1000 person years). Amongst those developing metabolic syndrome, ≥4 components were present in 52% individuals, with low HDL-C being the most common abnormality. Those with metabolic syndrome had a five-time higher risk of diabetes (OR: 4.94; 95% CI: 2.27–9.96; p < 0.001) and a threefold higher risk of hypertension (OR: 2.67; 95% CI: 1.30–5.48; p = 0.006). Conclusion Asian-Indians have a high incidence rate of metabolic syndrome, which is associated with sedentary lifestyle and consequent central obesity.

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Gender Difference in Intraocular Pressure and Incidence of Metabolic Syndrome: A Community-Based Cohort Study in Matsu, Taiwan

Cited by 8 publications

References 13 publications

Serum Calcium Level as a Useful Surrogate for Risk of Elevated Intraocular Pressure

Serum Calcium Level as a Useful Surrogate for Risk of Elevated Intraocular Pressure

Gender Difference in the Prevalence of Insomnia: A Meta-Analysis of Observational Studies

Incidence and predictors of metabolic syndrome in Asian-Indians: a 10-year population-based prospective cohort study

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