Gender difference in hepatic AMPK pathway activated lipid metabolism induced by aged polystyrene microplastics exposure

Yang, Xiaona; Jiang, Jin; Wang, Qing; Duan, Jicheng; Chen, Na; Wu, Di; Xia, Yankai

doi:10.1016/j.ecoenv.2022.114105

Cited by 18 publications

(3 citation statements)

References 59 publications

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“…Notably, and in light of this disconnect, a common trend across lab studies was the lack of any rationale for the concentrations of microplastic that were administered. The 11 studies that did provide justification chose concentrations that were based either on the concentrations of microplastic found in rivers (Liu et al, 2022), or on existing in vivo studies (Choi et al, 2021, Hou et al, 2021; Li et al, 2020; Lou et al, 2019; Mu et al, 2022; Shi et al, 2022; Wang et al, 2022; Wang et al, 2022; Yang et al, 2019; Yang et al, 2022). For instance, Yang et al (2019) and Mu et al (2022), both based their study designs on work on mice by Deng et al (2017).…”

Section: Resultsmentioning

confidence: 99%

The need for ecologically realistic studies on the health effects of microplastics

Mills

Savanagouder

Ferraz

et al. 2022

Preprint

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Plastic pollution is now so widespread that microplastics are consistently detected in every biological sample surveyed for their presence. Despite their pervasiveness, very little is known about the effects of microplastics on the health of terrestrial species. While emerging studies are showing that microplastics represent a potentially serious threat to animal health, data have been limited to in vivo studies on laboratory rodents that were force fed plastics. The extent to which these studies are representative of the conditions that animals and humans might actually experience in the real world is largely unknown. Here, we review the peer-reviewed literature in order to understand how the concentrations and types of microplastics being administered in lab studies compare to those found in terrestrial soils. We found that lab studies have heretofore fed rodents microplastics at concentrations that were hundreds of thousands of times greater than they would be exposed to in nature. Furthermore, health effects have been studied for only 10% of the microplastic polymers that are known to occur in soils. The plastic pollution crisis is arguably one of the most pressing ecological and public health issues of our time, yet existing lab-based research on the health effects of terrestrial microplastics does not reflect the conditions that free-ranging animals are actually experiencing. Going forward, performing more true-to-life research will be of the utmost importance to understand the impacts of microplastics and maintain the public's faith in the scientific process.

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Section: Resultsmentioning

confidence: 99%

The need for ecologically realistic studies on the health effects of microplastics

Mills

Savanagouder

Ferraz

et al. 2022

Preprint

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“…Although few studies investigated the sex differences associated with MPs/NPs exposure, evidence suggests that liver metabolic and toxic effects may be worse for females [ 180 , 181 ], given the major impact of these plastic particles and their associated chemical additives (i.e., EDCs) on female reproductive parameters and functions [ 181 , 182 , 183 , 184 ].…”

Section: Nutrition Environmental Pollutants and Nafldmentioning

confidence: 99%

Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution

Dolce

Torre

2023

Nutrients

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Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease and represents an increasing public health issue given the limited treatment options and its association with several other metabolic and inflammatory disorders. The epidemic, still growing prevalence of NAFLD worldwide cannot be merely explained by changes in diet and lifestyle that occurred in the last few decades, nor from their association with genetic and epigenetic risk factors. It is conceivable that environmental pollutants, which act as endocrine and metabolic disruptors, may contribute to the spreading of this pathology due to their ability to enter the food chain and be ingested through contaminated food and water. Given the strict interplay between nutrients and the regulation of hepatic metabolism and reproductive functions in females, pollutant-induced metabolic dysfunctions may be of particular relevance for the female liver, dampening sex differences in NAFLD prevalence. Dietary intake of environmental pollutants can be particularly detrimental during gestation, when endocrine-disrupting chemicals may interfere with the programming of liver metabolism, accounting for the developmental origin of NAFLD in offspring. This review summarizes cause–effect evidence between environmental pollutants and increased incidence of NAFLD and emphasizes the need for further studies in this field.

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“…However, there is a strong heterogeneity in the dynamic changes of female reproductive endocrine related hormones caused by MPs/NPs. In an experiment using aged polystyrene microplastics (PSMPs), it was found that PSMPs could stimulate the production and release of estradiol (E2) and increase the expression of estrogen receptor ( Yang et al, 2022b ). This is controversial in light of the results obtained with primary MPs, which may be due to the modifications in the properties of plastic particles ( Wang et al, 2019 ).…”

Section: Endocrine Interference Of Mps/npsmentioning

confidence: 99%

Toxicity of microplastics and nanoplastics: invisible killers of female fertility and offspring health

Geng,

Liu,

et al. 2023

Front. Physiol.

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Microplastics (MPs) and nanoplastics (NPs) are emergent pollutants, which have sparked widespread concern. They can infiltrate the body via ingestion, inhalation, and cutaneous contact. As such, there is a general worry that MPs/NPs may have an impact on human health in addition to the environmental issues they engender. The threat of MPs/NPs to the liver, gastrointestinal system, and inflammatory levels have been thoroughly documented in the previous research. With the detection of MPs/NPs in fetal compartment and the prevalence of infertility, an increasing number of studies have put an emphasis on their reproductive toxicity in female. Moreover, MPs/NPs have the potential to interact with other contaminants, thus enhancing or diminishing the combined toxicity. This review summarizes the deleterious effects of MPs/NPs and co-exposure with other pollutants on female throughout the reproduction period of various species, spanning from reproductive failure to cross-generational developmental disorders in progenies. Although these impacts may not be directly extrapolated to humans, they do provide a framework for evaluating the potential mechanisms underlying the reproductive toxicity of MPs/NPs.

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Gender difference in hepatic AMPK pathway activated lipid metabolism induced by aged polystyrene microplastics exposure

Cited by 18 publications

References 59 publications

The need for ecologically realistic studies on the health effects of microplastics

The need for ecologically realistic studies on the health effects of microplastics

Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution

Toxicity of microplastics and nanoplastics: invisible killers of female fertility and offspring health

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