Gender Difference in Association between Metabolic Factors and Hepatocellular Carcinoma

Chen, Chi‐Ling; Kuo, Ming-Jeng; Yen, Amy Ming‐Fang; Yang, Wei–Shiung; Kao, Jia‐Horng; Chen, Pei‐Jer; Chen, Chien-Jen

doi:10.2139/ssrn.3449356

Cited by 2 publications

(3 citation statements)

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“…Men are more likely to be exposed to environmental risk factors for HCC such as alcohol and smoking [23]. Men are also more likely to have metabolic derangements, such as diabetes and metabolic syndrome, which are among the most dominant risk factors for HCC [24]. There is also recent evidence that estrogen may play a protective role in the development of HCC [22].…”

Section: Discussionmentioning

confidence: 99%

Duodenal Microbiome and Serum Metabolites Predict Hepatocellular Carcinoma in a Multicenter Cohort of Patients with Cirrhosis

et al. 2021

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Background Hepatocellular carcinoma (HCC) is rapidly increasing in the U.S. and is a leading cause of mortality for patients with cirrhosis. Discovering novel biomarkers for risk stratification of HCC is paramount. We examined biomarkers of the gut-liver axis in a prospective multicenter cohort. Methods Patients with cirrhosis without a history of HCC were recruited between May 2015 and March 2020 and prospectively followed at 3 tertiary care hospitals in Los Angeles. Microbiome analysis was performed on duodenal biopsies and metabolomic analysis was performed on serum samples, collected at the time of enrollment. Optimal microbiome-based survival analysis and Cox proportional hazards regression analysis were used to determine microbiota and metabolite associations with HCC development, respectively. Results A total of 227 participants with liver cirrhosis contributed a total of 459.58 person-years of follow-up, with 14 incident HCC diagnoses. Male sex (HR = 7.06, 95% CI = 1.02–54.86) and baseline hepatic encephalopathy (HE, HR = 4.65, 95% CI = 1.60–13.52) were associated with developing HCC over follow-up. Adjusting for age, sex, baseline HE, and alkaline phosphatase, an increased risk of HCC were observed for participants with the highest versus lowest three quartiles for duodenal Alloprevotella (HR = 3.22, 95% CI = 1.06–9.73) and serum taurocholic acid (HR = 6.87, 95% CI = 2.32–20.27), methionine (HR = 9.97, 95% CI = 3.02–32.94), and methioninesulfoxide (HR = 5.60, 95% CI = 1.84–17.10). Being in the highest quartile for Alloprevotella or methionine had a sensitivity and specificity for developing HCC of 85.71% and 60.56%, respectively, with an odds ratio of 10.92 (95% CI = 2.23–53.48). Conclusion Alloprevotella and methionine, methioninesulfoxide, and taurocholic acid predicted future HCC development in a high-risk population of participants with liver cirrhosis. Supplementary Information The online version contains supplementary material available at 10.1007/s10620-021-07299-2.

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Section: Discussionmentioning

confidence: 99%

Duodenal Microbiome and Serum Metabolites Predict Hepatocellular Carcinoma in a Multicenter Cohort of Patients with Cirrhosis

et al. 2021

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“…Obesity has been associated with a higher risk of HCC incidence in men than women, especially in non-Asians [25] . A recent study conducted in an Asian population found a different relationship between BMI and HCC risk according to sex, following a U-shaped and a linear curve in men and women, respectively [26] . Studies reported a stronger risk association between pre-diabetes/diabetes and HCC in men than women [26][27][28] .…”

Section: Interaction Between Sex/gender and Metabolic Risk Factorsmentioning

confidence: 97%

“…Prospective studies indicate that regular alcohol intake, although within safe thresholds, is a risk factor for the progression to HCC among individuals with NAFLD [31] . Moreover, among those with HCC, alcohol use is more frequent in men than in women [26,32] .…”

Section: Interaction Between Sex/gender and Metabolic Risk Factorsmentioning

confidence: 99%

Sex disparity in hepatocellular carcinoma owing to NAFLD and non-NAFLD etiology: epidemiological findings and pathobiological mechanisms

Lonardo¹,

Ballestri²,

Chow³

et al. 2020

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Gender Difference in Association between Metabolic Factors and Hepatocellular Carcinoma

Cited by 2 publications

References 0 publications

Duodenal Microbiome and Serum Metabolites Predict Hepatocellular Carcinoma in a Multicenter Cohort of Patients with Cirrhosis

Duodenal Microbiome and Serum Metabolites Predict Hepatocellular Carcinoma in a Multicenter Cohort of Patients with Cirrhosis

Sex disparity in hepatocellular carcinoma owing to NAFLD and non-NAFLD etiology: epidemiological findings and pathobiological mechanisms

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