Gender difference in allergic airway remodelling and immunoglobulin production in mouse model of asthma

Takeda, Masahide; Tanabe, Masako; Ito, Wataru; Ueki, Shigeharu; Konnno, Yasunori; Chihara, Mami; Itoga, Masamichi; Kobayashi, Yoshiki; Moritoki, Yuki; Kayaba, Hiroyuki; Chihara, Junichi

doi:10.1111/resp.12078

Cited by 95 publications

(71 citation statements)

References 37 publications

(40 reference statements)

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“…It had been proven that VAS positively correlates with the Rhinoconjunctivitis Quality of Life Questionnaire global score and could be used for the quantitative evaluation of the severity of AR. 13 In this study, we found a statistically significant correlation between the grading of the severity (IM, PM, and IMS to PMS) and VAS scores (Spearman r ϭ 0.263; p Ͻ 0.001). The results correspond to the findings that Bousquet reported previously.…”

Section: Discussionmentioning

confidence: 74%

A Multicenter Study of the Clinical Features of Allergic Rhinitis in Central China

Chen

Zhao

et al. 2014

Am J Rhinol�Allergy

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Section: Discussionmentioning

confidence: 74%

A Multicenter Study of the Clinical Features of Allergic Rhinitis in Central China

Chen

Zhao

et al. 2014

Am J Rhinol�Allergy

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“…However, OVA-challenged females had increased airway remodeling and mucus production compared to male mice in some reports (50, 51), but no differences were found in others (52•). Presence of ovarian hormones during the sensitization phase is required for maximal Th2-mediated airway inflammation in female mice.…”

Section: Role Of Sex Hormones In Airway Inflammation – Summary Of Animentioning

confidence: 84%

Mechanisms Driving Gender Differences in Asthma

Fuseini

Newcomb

2017

Curr Allergy Asthma Rep

319

226

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Purpose of Review Many phenotypes of asthma exist, ranging from mild asthma with onset during childhood to severe asthma with later onset, making asthma a broad disease with different pathologies. A gender disparity exists in asthma prevalence. As adults, women have an increased asthma prevalence compared to men. Further, women are more likely to have severe asthma and a later onset of asthma compared to men. Here, we review clinical and animal studies that have defined the role of sex hormones in airway inflammation, smooth muscle contraction, mucus production, and airway mechanics associated with asthma pathogenesis. Recent Findings Clinical evidence shows that increased asthma symptoms occur in females starting at puberty compared to boys. However, after puberty, the role for sex hormones in regulating asthma symptoms during menstruation, pregnancy, and menopause is not as clear. Animal studies have shown that estrogen increases and testosterone decreases Th2-mediated airway inflammation, and that females have increased IL-17A-mediated airway inflammation compared to males. Further, females had increased DC and Mφ function compared to males. However, the mechanisms driving the types of allergic inflammation are not fully elucidated. Summary Overall, ovarian hormones increased and testosterone decreased airway inflammation in asthma, but the mechanisms remain unclear. Delineating these pathways using animal models as well as women and men with various phenotypes of asthma will help determine if women with asthma should take (or avoid) hormonal contraceptives as well as predict changes asthma symptoms during life phases, including pregnancy and menopause, when sex hormones are dramatically changing.

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“…Because of the gender differences in asthma onset and respiratory symptoms (Hansen et al, 2015;Takeda et al, 2013), we stratified the allele frequencies and genotypes by gender. However, no statistically significant differences in genotype or allele frequency distribution were found for rs2228145 and rs12083537 between patients and controls in either males or females (supporting Tables 1 and 2).…”

Section: The Genotype and Allele Frequency Distributions In Patients mentioning

confidence: 99%

The IL6R gene polymorphisms are associated with sIL-6R, IgE and lung function in Chinese patients with asthma

Wang

et al. 2016

Gene

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Gender difference in allergic airway remodelling and immunoglobulin production in mouse model of asthma

Abstract: These results indicate that female mice experience more airway remodelling compared with male mice. These results suggest the involvement of sex hormones and gender differences in cellular functions in airway remodelling.

Cited by 95 publications

References 37 publications

A Multicenter Study of the Clinical Features of Allergic Rhinitis in Central China

A Multicenter Study of the Clinical Features of Allergic Rhinitis in Central China

Mechanisms Driving Gender Differences in Asthma

The IL6R gene polymorphisms are associated with sIL-6R, IgE and lung function in Chinese patients with asthma

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