Gender Difference in Alcoholic Liver Disease

Shimizu, Ichiro; Kamochi, Mari; Yoshikawa, Hideshi; Nakayama, Yoshiyuki

doi:10.5772/27178

Cited by 17 publications

(24 citation statements)

References 75 publications

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“…We found higher male gender predilection, which may be partially related to higher alcohol consumption. 26 Of the 33 patients with alcoholic liver disease, identified in this review, 88% were male. Other possible hormonal, genetic or acquired factors may be in play.…”

Section: Discussionmentioning

confidence: 96%

Peribiliary cysts: a systematic review and proposal of a classification framework

Bazerbachi

Haffar²,

Sugihara

et al. 2018

BMJ Open Gastroenterol

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ObjectivePeribiliary cysts are usually benign, although severe complications and mortality may occur, and they may be confounded with other diseases. No classification delineating their different characteristics exists.DesignWe performed a systematic review of the frequency and clinical manifestations of peribiliary cysts. Two reviewers identified studies after searching multiple databases on 2 August 2017.ResultsThese cysts were prevalent in cirrhosis (9%). A total of 135 patients were reported in 72 papers with sufficient clinical data (10 countries, 65% from Japan, median age 63 years (range: 4–88), and 80% were males). Symptoms were present in 70%. Misdiagnosis occurred in 40%, and 33% underwent therapeutic misadventures. Cysts were solitary in 10%. Obstructive features and cholangitis were observed in 36% and 12.5%, respectively. Cysts progression was observed in 37.5% over a median of 18 months. Mortality was 24%, mostly due to cirrhosis. A classification framework is proposed, wherein type I includes hepatic, type II extrahepatic and type III mixed hepatic and extrahepatic cysts, each having distinct features. Specifically, type II was more frequent in females, solitary, without cirrhosis, presenting with obstructive jaundice, more difficult to diagnose and required more surgical interventions (all p<0.05).ConclusionAlthough rarely studied in the literature, peribiliary cysts were frequent in studies designed to evaluate their prevalence, and were mostly asymptomatic. Inaccurate diagnosis, therapeutic misadventures, cysts progression and cysts-related complications are frequent. In a novel classification framework based on location, extrahepatic peribiliary cysts have distinct characteristics and require a special approach for diagnosis and management.

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Section: Discussionmentioning

confidence: 96%

Peribiliary cysts: a systematic review and proposal of a classification framework

Bazerbachi

Haffar²,

Sugihara

et al. 2018

BMJ Open Gastroenterol

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“…The observed age distribution could be reflective of the overall Ugandan population, where 21.2% of the Ugandan population was found to be between 15–24 years and 25.5% between 25–54 years (Uganda Demographics Profile of 2013, Uganda bureau of statistics). The male gender predisposition could be a result of disparity in distribution of the etiological factors that influence UGIB in both genders such as gastritis, PUD and liver cirrhosis caused by viral hepatitis and alcohol abuse 14 , 16 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence, short term outcome and factors associated with survival in patients suffering from upper gastrointestinal bleeding in a resource limited-setting, the case of Mulago hospital in Kampala, Uganda

et al. 2020

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Background: Upper gastrointestinal bleeding (UGIB) is a common cause of admission and death in the gastroenterology service. The prevalence, risk factors and the case fatality rate of UGIB may differ by settings. Objectives: Our objective was to determine the prevalence of symptoms and the case fatality rate of UGIB among patients at the gastroenterology service of Mulago Hospital in Kampala, Uganda and to describe the clinical and laboratory risk fac- tors associated with the survival of these patients. Methods: In a cross-sectional study performed between September 2013 and April 2014, patients were screened for UGIB symptoms. Data was collected on socio-demographic characteristics, clinical presentation and patient’s outcome within one week of admission. Bivariate, multivariate, and survival analysis were performed to identify variables that were significantly associated with mortality. Results: Out of 1085 patients screened, we identified the prevalence of UGIB symptoms in 220 patients (20.3%). Among these, 150 met the inclusion criteria for our study. The majority were males (70.7%) and 40 years of age or less (60%). The most prevalent clinical diagnosis were gastritis (39.3%), esophageal varices (17.3%) and peptic ulcer disease (PUD) (16%). Among patients who underwent endoscopy, esophageal varices (42.2%), PUD (26.3%) and gastritis (15.8%) were the lead- ing causes of bleeding. The overall case fatality rate was 16.7% (25/150). Uremia remained associated with mortality after controlling for confounders. Survival was significantly reduced for males as well as for patients with uremia and malignancy. Conclusion: the prevalence of symptoms and the case fatality rate of UGIB among patients admitted to the gastroenter- ology ward in Mulago hospital were higher than in developed countries and similar to other resource-limited setting. The majority of patients were young men and presented with both hematemesis and melena. The most common causes of UGIB were esophageal varices, gastritis and PUD. Survival analysis indicate that male gender, uremia, and malignancy are associated with reduced survival. Keyword: Upper gastrointestinal bleeding; gastroenterology; survival; Uganda; Africa.

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“…Overall men consume alcohol more than women. 30 The combined effects of alcohol and obesity may synergistically induce hepatocellular injury, inflammation, fibrosis and the development of cancer. 31 Even at moderate doses alcohol exacerbates the pathological effects of obesity on the liver, as the threshold for hepatotoxic alcohol effects in obese populations is lower than for normal weight individuals.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics vary between women and men in 67,524 patients with moderate obesity preoperative for laparoscopic adjustable gastric band (LAGB)

Bashian¹,

Schwartz²,

Perry³

et al. 2020

AOWMC

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Background: As of 2018, LAGB represents <2% of weight loss operations, but with excellent long-term outcomes in selected patients. Thus, every clinical insight can help in selecting LAGB patients and planning surgery. While more women than men undergo bariatric surgery, differences between the sexes in obesity-related clinical conditions pre-operatively among patients seeking LAGB have not been investigated. The objective of this study was to identify variations in obesity-related co-morbidities among women and men who chose laparoscopic adjustable gastric band (LAGB). Methods: Pre-operative data on 53,292 women and 14,222 men undergoing LAGB were examined retrospectively from the Surgical Review Corporation’s Bariatric Outcomes Longitudinal Database (BOLD). Results: Women were more frequently African American and on Medicaid while men were more frequently Caucasian insured with Medicare. Men were older, heavier, and used alcohol, tobacco, and illicit substances more frequently. Men had higher rates of cardiovascular and pulmonary disease, diabetes, gout, impaired functional status, abdominal hernia, and liver disease. Women had higher rates of asthma, cholelithiasis, urinary incontinence, panniculitis, and mental health. Conclusion: Pre-operative characteristics of LAGB patients vary by sex. This clinical knowledge may aid physicians and surgeons in facilitating anticipatory management of patients with moderate obesity

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Gender Difference in Alcoholic Liver Disease

Cited by 17 publications

References 75 publications

Peribiliary cysts: a systematic review and proposal of a classification framework

Peribiliary cysts: a systematic review and proposal of a classification framework

Prevalence, short term outcome and factors associated with survival in patients suffering from upper gastrointestinal bleeding in a resource limited-setting, the case of Mulago hospital in Kampala, Uganda

Clinical characteristics vary between women and men in 67,524 patients with moderate obesity preoperative for laparoscopic adjustable gastric band (LAGB)

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