Gender‐biased kidney damage in mice following exposure to tobacco cigarette smoke: More protection in premenopausal females

Kaplan, Abdullah; Abidi, Emna; Habeichi, Nada; Ghali, Rana; Alawasi, Hiam; Fakih, Christina; Zibara, Kazem; Kobeissy, Firas; Husari, Ahmad; Booz, George W.; Zouein, Fouad A.

doi:10.14814/phy2.14339

Cited by 7 publications

(7 citation statements)

References 137 publications

(154 reference statements)

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“…Mice were exposed to CS using an exposure apparatus with single animal modules (ONARES, CH Technologies, NJ, USA) as previously described [27][28][29]. Mice were familiarized with the apparatus over the 7 days prior by daily exposures without CS.…”

Section: Cigarette Smoking Exposurementioning

confidence: 99%

Sex differences in cardiac remodeling post myocardial infarction with acute cigarette smoking

et al. 2022

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Background Whether cigarette smoking affects the heart post-myocardial infarction (MI) in a sex-dependent way remains controversial. Using a mouse model, we investigated cardiac remodeling under the influence of acute cigarette smoke (CS) exposure following ischemic injury in both sexes. Methods Ten cigarettes were smoked twice daily for 2 weeks followed by MI and then 1 additional week post permanent LAD ligation. Cardiac function, histology, and infarct size were assessed, and inflammatory markers quantified by RT–PCR. Statistical comparisons were performed using an unpaired t test or ANOVA followed by Tukey post hoc test. Results We observed that cigarette smoking exacerbated both left and right ventricular remodeling only in males at an early stage of post-MI. Females did not display a significant structural and/or functional alteration within 7 days of cardiac remodeling post-MI upon CS exposure. Worsened right ventricular remodeling in males was independent of pulmonary congestion. CS-exposed males exhibited enhanced increases in left ventricular end systolic and diastolic volumes, as well as reductions in ejection fraction and fractional area changes of left ventricular base. At day 7, infarct size was increased by cigarette smoking in males only, which was accompanied by enhanced collagen deposition in both the infarcted and peri-infarcted areas. Both IL-6 and TNF-α mRNA expression significantly increased in CS-exposed MI male group only at day 7 post-MI suggestive of prolonged inflammation. Conclusions These findings indicate that CS exposure worsens the progression of cardiac remodeling post-MI in male sex in a significant manner compared to female sex at least at early stages.

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Section: Cigarette Smoking Exposurementioning

confidence: 99%

Sex differences in cardiac remodeling post myocardial infarction with acute cigarette smoking

et al. 2022

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Section: Cigarette Smoking Exposurementioning

confidence: 99%

Sex Differences in Cardiac Remodeling Post Myocardial Infarction with Acute Cigarette Smoking

Kaplan

Abidi

Diab

et al. 2022

Preprint

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Background. Whether cigarette smoking affects the heart post-myocardial infarction (MI) in a sex-dependent way remains controversial. Using a mouse model, we investigated cardiac remodeling under the influence of acute cigarette smoke (CS) exposure following ischemic injury in both sexes. Methods. Ten cigarettes were smoked twice daily for 2 weeks followed by MI and then 1 additional week post permanent LAD ligation. Cardiac function, histology, and infarct size were assessed, and inflammatory markers quantified by RT-PCR. Statistical comparisons were performed using an unpaired t-test or ANOVA followed by Tukey post hoc test. Results. We observed that cigarette smoking exacerbated both left and right ventricular remodeling only in males at an early stage of post-MI. Females did not display a significant structural and/or functional alteration within 7 days of cardiac remodeling post-MI upon CS exposure. Worsened right ventricular remodeling in males was independent of pulmonary congestion. CS-exposed males exhibited enhanced increases in left ventricular end systolic and diastolic volumes, as well as reductions in ejection fraction and fractional area changes of left ventricular base. At day 7, infarct size was increased by cigarette smoking in males only, which was accompanied by enhanced collagen deposition in both the infarcted and peri-infarcted areas. Both IL-6 and TNF-α mRNA expression significantly increased in CS-exposed MI male group only at day 7 post-MI suggestive of prolonged inflammation. Conclusions. These findings indicate that CS exposure worsens the progression of cardiac remodeling post-MI in male sex in a significant manner compared to female sex at least at early stages.

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“…Kadmium, timbal, dan nikotin merupakan kandungan asap rokok yang terbukti bersifat nefrotoksik. Nikotin diketahui meningkatkan fibrosis dan inflamasi pada tubulus proksimal dan menginduksi apoptosis sel podosit ginjal 9 . Mukosa hati, ginjal, paru-paru dan mulut adalah organ tubuh yang terlibat dalam pengaturan metabolisme nikotin yang merusak sistem kardiovaskular dan kelenjar endokrin.…”

Section: Pembahasanunclassified

Hubungan Antara Merokok Dengan Gambaran Fungsi Ginjal Pada Karyawan PT.X

Syamsi

Tanra

Hs³

2021

HTJ

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The chronic kidney disease is a global health problem with increasing prevalence and incidence and a poor prognosis. Therefore, those brought about by risk factors are primarily those which can be modified and controlled for their occurrence. One of the risk factor is smoking habit. The objective of this study was to determine the associations between smoking and renal function profiles in PT.X employees. The study was conducted by using descriptive analytical study with a cross sectional design based on smoking habits and blood test samples of employees. The sample were 40 employees in PT.X which determined by consecutive sampling. The results showed that there were no associations between smoking with age (p = 0.222) and azotemia (p = 1.00) but there were associations between smoking and blood creatinine levels (p = 0.001), urea (p = 0.023), eGFR (p. = 0.001), and the stages of chronic kidney disease (p = 0.047). Based on the study results, in can be concluded that there were associations between smoking and renal function profiles among employees of PT. X

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Gender‐biased kidney damage in mice following exposure to tobacco cigarette smoke: More protection in premenopausal females

Cited by 7 publications

References 137 publications

Sex differences in cardiac remodeling post myocardial infarction with acute cigarette smoking

Sex differences in cardiac remodeling post myocardial infarction with acute cigarette smoking

Sex Differences in Cardiac Remodeling Post Myocardial Infarction with Acute Cigarette Smoking

Hubungan Antara Merokok Dengan Gambaran Fungsi Ginjal Pada Karyawan PT.X

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