Gender bias in individual radiosensitivity and the association with genetic polymorphic variations

Almeer, Rafa; Al-Harbi, Najla; Judia, Sara Bin; Al-Buhairi, Muneera; Venturina, Nikki Q.; Moftah, Belal

doi:10.1016/j.radonc.2016.02.034

Cited by 36 publications

(32 citation statements)

References 42 publications

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“…In vitro data showed that human fibroblasts carrying the minor alleles of the rs1801516 polymorphism increased cellular radiosensitivity compared with those carrying the major alleles [51, 52]. Some variants of the ATM gene, including the rs1801516 polymorphism, were reported to be associated with a decreased ATM expression and a reduced capacity of DNA damage recognition [42, 53].…”

Section: Discussionmentioning

confidence: 99%

“…Based on these data, it was difficult to figure out how this single polymorphism might be associated with a decreased cancer risk for individuals who were exposed to radiation. Instead, a gene-gene interaction of the ATM gene with BRCA1 has been reported [28, 52]. Therefore, it could be expected that the polygenic action of unidentified alleles or genes probably played a non-negligible role on the function of the rs1801516 polymorphism.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gene-environment interaction for polymorphisms in ataxia telangiectasia-mutated gene and radiation exposure in carcinogenesis: results from two literature-based meta-analyses of 27120 participants

Zhao

Yang

et al. 2016

Oncotarget

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PurposeWe conducted two meta-analyses of ATM genetic polymorphisms and cancer risk in individuals with or without radiation exposure to determine whether there was a joint effect between the ATM gene and radiation exposure in carcinogenesis.Resultsrs1801516, which was the only ATM polymorphism investigated by more than 3 studies of radiation exposure, was eligible for the present study. The meta-analysis of 23333 individuals without radiation exposure from 24 studies showed no association between the rs1801516 polymorphism and cancer risk, without heterogeneity across studies. The meta-analysis of 3787 individuals with radiation exposure from 6 studies showed a significant association between the rs1801516 polymorphism and a decreased cancer risk, with heterogeneity across studies. There was a borderline-significant difference between the ORs of the two meta-analyses (P = 0.066), and the difference was significant when only Caucasians were included (P = 0.011).Materials and methodsPublications were identified by searching PubMed, EMBASE, Web of Science, and CNKI databases. Odds ratios (ORs) were calculated to estimate the association between ATM genetic polymorphisms and cancer risk. Tests of interaction were used to compare differences between the ORs of the two meta-analyses.ConclusionsOur meta-analyses confirmed the presence of a gene-environment interaction between the rs1801516 polymorphism and radiation exposure in carcinogenesis, whereas no association was found between the rs1801516 polymorphism and cancer risk for individuals without radiation exposure. The heterogeneity observed in the meta-analysis of individuals with radiation exposure might be due to gene-ethnicity or gene-gene interactions. Further studies are needed to elucidate sources of the heterogeneity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gene-environment interaction for polymorphisms in ataxia telangiectasia-mutated gene and radiation exposure in carcinogenesis: results from two literature-based meta-analyses of 27120 participants

Zhao

Yang

et al. 2016

Oncotarget

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“…In the International Commission on Radiological Protection Publication (ICRP) in 2007, after a similar dose of radiation exposure, women have a higher risk of cancer and death than men . One study reported that women and men differ significantly in radiosensitivity ( P = 0.004), which is associated with variations in single nucleotide polymorphisms . A group from Germany reported that estradiol treatment can increase the intrinsic radiosensitivity of breast cancer cells .…”

Section: Discussionmentioning

confidence: 99%

Increased risk of pelvic fracture after radiotherapy in rectal cancer survivors: A propensity matched study

et al. 2019

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To determine whether radiotherapy ( RT ) can increase pelvic fracture risk in rectal cancer survivors. Rectal cancer patients who underwent curative surgery between 1996 and 2011 in Taiwan were retrospectively studied using the National Health Insurance Research Database ( NHIRD ) of Taiwan. ICD ‐9 Codes 808, 805.4‐805.7, 806.4‐806.7, and 820 (including pelvic, sacrum, lumbar, and femoral neck fracture) were defined as pelvic fracture. Propensity scores for RT , age, and sex were used to perform one‐to‐one matches between the RT and non‐ RT group. Risks of pelvic and arm fractures were compared by multivariable Cox regression. Of the 32 689 patients, 7807 (23.9%) received RT , and 1616 suffered from a pelvic fracture (incidence rate: 1.17/100 person‐years). The median time to pelvic fracture was 2.47 years. After matching, 6952 patients each in the RT and non‐ RT groups were analyzed. RT was associated with an increased risk of pelvic fractures in the multivariable Cox model (hazard ratio ( HR ): 1.246, 95% confidence interval ( CI ): 1.037‐1.495, P = 0.019) but not with arm fractures ( HR : 1.013, 95% CI : 0.814‐1.259, P = 0.911). Subgroup analyses revealed that RT was associated with a higher pelvic fracture rate in women ( HR : 1.431, 95% CI : 1.117‐1.834) but not in men, and the interaction between sex and RT was significant ( P = 0.03). The HR of pelvic fracture increased 2‐4 years after RT ( HR : 1.707, 95% CI : 1.150‐2.534, P = 0.008). An increased risk of pelvic fracture is noted in rectal cancer survivors, especially women, who receive RT .

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“…Such results also point to the need of separate epidemiological analyses for men and women after overexposure to ionizing radiation in order to avoid possible bias and incorrect interpretation of data (Alsbeih et al 2016).…”

Section: Induced Genome Damage and Pathology Gender Difference In Genmentioning

confidence: 99%

Follow-up studies on genome damage in children after Chernobyl nuclear power plant accident

et al. 2016

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As children are more susceptible to ionizing radiation than adults, each nuclear accident demands special attention and care of this vulnerable population. The Chernobyl nuclear disaster occurred in a region populated with a large number of children, but despite all efforts and expertise of nuclear specialists, it was not possible to avoid casualties. As vast regions of Ukraine, Belarus and Russia were exposed to doses of ionizing radiation, which are known to be related with different diseases, shortly after the accident medical surveillance was launched, which also included analysis of genome damage. Child population affected by internal and external radiation consisted of subjects exposed prenatally, postnatally (both evacuated and non-evacuated), born by irradiated fathers who worked as liquidators, and parents exposed environmentally. In all groups of children during the last 30 years who were exposed to doses which were significantly higher than that recommended for general population of 1 mSv per year, increased genome damage was detected. Increased genome damage includes statistically higher frequency of dicentric and ring chromosomes, chromated and chromosome breaks, acentric fragments, translocations, and micronuclei. The presence of rogue cells confirmed internal contamination. Genome instability and radiosensitivity in children was detected both in evacuated and continuously exposed children. Today the population exposed to ionizing radiation in 1986 is in reproductive period of life and follow-up of this population and their offspring is of great importance. This review aims to give insight in results of studies, which reported genome damage in children in journals without language restrictions.

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Gender bias in individual radiosensitivity and the association with genetic polymorphic variations

Cited by 36 publications

References 42 publications

Gene-environment interaction for polymorphisms in ataxia telangiectasia-mutated gene and radiation exposure in carcinogenesis: results from two literature-based meta-analyses of 27120 participants

Gene-environment interaction for polymorphisms in ataxia telangiectasia-mutated gene and radiation exposure in carcinogenesis: results from two literature-based meta-analyses of 27120 participants

Increased risk of pelvic fracture after radiotherapy in rectal cancer survivors: A propensity matched study

Follow-up studies on genome damage in children after Chernobyl nuclear power plant accident

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