Gender and skeletal muscle characteristics in subjects with chronic obstructive pulmonary disease

Torres, Sonia H.; de, María Montes; Loeb, Eduardo; Mata, Abdón; Hernández, Noelina

doi:10.1016/j.rmed.2010.05.010

Cited by 15 publications

(18 citation statements)

References 33 publications

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“…Secondly, the subjects recruited in the present study were all males. Although Lopez Varela et al [32] reported that women with COPD showed greater physical limitations than men, Torres et al [33] reported that gender differences in skeletal muscle characteristics were not found in COPD patients. The importance of the validation study, however, is the difference between the absolute activity and the measured activity.…”

Section: Discussionmentioning

confidence: 99%

Validation of a Compact Motion Sensor for the Measurement of Physical Activity in Patients with Chronic Obstructive Pulmonary Disease

et al. 2011

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Background: The DynaPort Activity Monitor (DAM) has been reported to be useful to evaluate the activity in healthy subjects and patients with chronic obstructive pulmonary disease (COPD). However, it is difficult to estimate the activity of COPD patients using DAM, because its battery works only for several hours and sensors should be worn at two parts of the body. A newly developed compact, single-position triaxial accelerometer (Actimarker) can measure the activity for >1 month, but has not been validated for COPD patients. Objectives: The validity of the Actimarker was evaluated in COPD patients. Methods: In study 1, the validity of the device was tested in 14 stable COPD patients by comparing it with DAM. In study 2, the influence of the weather on activity was examined. In study 3, the number of measurement days required to ensure repeatability was determined. Results: The durations of activity measured by the Actimarker and DAM were significantly correlated at intensity values ≧2.0, ≧2.5 and ≧3.0 METs. The duration of activity on rainy days was significantly shorter than that on non-rainy days. The values of intraclass correlation coefficients were >0.8 in 3-, 4- or 5-day measurements, and there was no systematic bias at any number of days or intensities with Bland-Altman plots. Conclusions: The validity of the Actimarker was confirmed, and repeatability was obtained when the data from at least 3 non-rainy weekdays were analyzed. Actimarker appears to be useful as a simplified method to evaluate the physical activity of COPD patients.

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Section: Discussionmentioning

confidence: 99%

Validation of a Compact Motion Sensor for the Measurement of Physical Activity in Patients with Chronic Obstructive Pulmonary Disease

et al. 2011

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“…Higher muscle fatigue in COPD patients may be due to lower levels of high-energy phosphates, lower mitochondrial density, early lactacidemia, or reduced muscle perfusion 43. However, in men and women with COPD with similar exercise capacity, no differences have been found in fiber type composition, mitochondrial density, and muscle enzyme activities in the quadriceps femoris muscle 44. On the other hand, Janaudis-Ferreira et al20 found more pronounced thigh muscle dysfunction, including muscle fatigue, among women than among men with COPD.…”

Section: Discussionmentioning

confidence: 99%

Experience of fatigue, and its relationship to physical capacity and disease severity in men and women with COPD

Tödt¹,

Skargren²,

Kentson³

et al. 2013

COPD

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IntroductionSeveral differences have been reported in the clinical characteristics of chronic obstructive pulmonary disease (COPD) between men and women. Differences have been found in the association between respiratory symptoms and lung function, and in the factors associated with dyspnea. This raises the question of whether there are differences between the sexes in the relationship between fatigue, the second most prevalent symptom, and the variables of physical capacity and disease severity.ObjectivesTo examine the experience of fatigue and its relationship to physical capacity and disease severity in men and women with COPD.MethodsIn a cross-sectional study 121 patients with COPD (54 men and 67 women), the experience of fatigue (frequency, duration, and severity) and physical capacity (lung function, 6-minute walk distance [6MWD], grip strength, and timed-stand test) were assessed. Disease severity was graded according to the Body mass index, airway Obstruction, Dyspnoea and Exercise capacity (BODE) index. Two multiple logistic regression models were tested, both of which were performed separately in men and women, to examine the association between the experience of fatigue and variables of physical capacity and the BODE index.ResultsEighty-nine (73.6%) patients experienced fatigue, with similar proportions in men and women. The men with fatigue had worse physical capacity and more severe disease than did the men without fatigue: for men with and without fatigue, respectively, the percent of predicted forced expiratory volume in 1 second (FEV1) (mean [standard deviation]) was 47 (14) vs 64 (17); the 6MWD (mean [standard deviation]) was 398 (138) vs 539 (105) m; and the BODE index (median [quartile 1–3]) was 3 (2–5) vs 1 (0–1) (P<0.01). In women, only higher leg fatigue post-6MWD was seen among those experiencing fatigue compared with women without fatigue: for women with and without fatigue, respectively, leg fatigue (median [quartile 1–3]) was 4 (3–5) vs 2 (0–3) (P<0.001). The regression models showed that the 6MWD and the BODE index were associated with fatigue in both men and women, but in women, leg fatigue remained an independent associate in both models.ConclusionExercise capacity and disease severity were associated with fatigue in both men and women. In women, leg fatigue was strongly associated with fatigue, which warrants further investigation.

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“…A fibre-type switch towards a less fatigue-resistant phenotype (from slow-twitch to fast-twitch fibres) is a major feature in the vastus lateralis of patients with advanced COPD [33][34][35][36] . Furthermore, fast-twitch fibres are also of smaller size in patients with advanced COPD and poor muscle mass [33][34][35] , thus contributing to muscle weakness.…”

Section: Quadriceps Muscle Dysfunctionmentioning

confidence: 99%

“…2016;2 inflammation 48 , hypoxia inducible factor-1 signalling pathway 49 , oxidative stress 50,51 , and reduced oxidative enzyme capacity and capillary numbers 36,52 . Hypercapnia, which may worsen during exacerbations, may also play a role in COPD muscle dysfunction through acidosis as it enhances ubiquitin-proteasome proteolytic system activity and/or through a reduction in protein anabolism 53 (Fig.…”

Section: Quadriceps Muscle Dysfunctionmentioning

confidence: 99%

Skeletal Muscle Dysfunction: From Chronic Respiratory Disease to Critically Ill Patients

Barreiro¹

2016

BRN

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Muscle dysfunction, defined as the loss of either strength or endurance properties of muscles, is a prominent comorbidity in chronic obstructive pulmonary disease (COPD) that leads to impairment of the patients' exercise capacity and quality of life. Chronic obstructive pulmonary disease skeletal muscle dysfunction may affect both respiratory and limb muscles. However, the latter are usually more severely affected. Importantly, survival and COPD mortality are negatively influenced by dysfunction of the lower limb muscles and poor muscle mass as measured by mid-thigh cross-sectional area. In the current review, we discuss the effects of skeletal muscle dysfunction and wasting on the outcome of COPD. Additionally, whether muscle dysfunction takes place in respiratory disorders other than COPD, such as cystic fibrosis, idiopathic pulmonary fibrosis, scoliosis, and pulmonary arterial hypertension along with critical illness, is also reviewed herein. Identification of skeletal muscle dysfunction should be included in the routine assessment of patients with chronic respiratory disorders and in critical care settings and should be considered as a relevant target for treatment. Corresponding author: Esther Barreiro, ebarreiro@imim.es

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Gender and skeletal muscle characteristics in subjects with chronic obstructive pulmonary disease

Cited by 15 publications

References 33 publications

Validation of a Compact Motion Sensor for the Measurement of Physical Activity in Patients with Chronic Obstructive Pulmonary Disease

Validation of a Compact Motion Sensor for the Measurement of Physical Activity in Patients with Chronic Obstructive Pulmonary Disease

Experience of fatigue, and its relationship to physical capacity and disease severity in men and women with COPD

Skeletal Muscle Dysfunction: From Chronic Respiratory Disease to Critically Ill Patients

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