In Nigeria, the prevalence of irregular migration, human trafficking, and modern slavery reflects a socio-political deficiencies and a pure socio-economic imbalance between the rich and the poor. As a result, this study investigated the determinants and consequences of irregular migration, human trafficking, and modern slavery in Nigeria in the context of national and international perspectives. Several variables were believed to be determining factors of these events based on what is apparent in the existing literature reviewed, including poverty, low standard of living, insecurity, wealth disparity, leadership flaws, and a low level of education. This paper then concludes that, given the globalising nature of these events (irregular migration, human trafficking, and modern slavery), it would be extraordinarily impossible for any single country to adequately address the tremendous consequences emanating from these social events.