Gender and Irritable Bowel Syndrome

Miller, Vivien; Whitaker, Kim; Morris, Julie; Whorwell, Peter J.

doi:10.1097/00004836-200408000-00004

Cited by 33 publications

(36 citation statements)

References 10 publications

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“…However, IBS considerably reduces quality of life to the same degree of impairment as major chronic diseases, including diabetes, congestive heart failure, renal insufficiency and hepatic cirrhosis (17)(18)(19)(20)(21). Besides the increased morbidity caused by IBS, the syndrome is an economic burden to society in varying forms, for example by increasing the incidence of sick leave and the over-consumption of healthcare resources (1).…”

Section: Introductionmentioning

confidence: 99%

Low-grade inflammation in the rectum of patients with sporadic irritable bowel syndrome

Gundersen¹,

Hatlebakk

Hausken

2013

Molecular Medicine Reports

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Abstract. Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder that considerably reduces quality of life and is an economic burden on society. The pathogenesis of IBS is unknown. However, intestinal low-grade inflammation has been proposed as one of the factors contributing to the development of IBS. The present study aimed to examine the possible occurrence of low-grade inflammation in the rectum of patients with sporadic IBS. In total, 50 patients (42 females and 8 males with an average age of 34 years) with sporadic IBS fulfilling the Rome III Criteria were recruited for this study. Of these, 30 patients had IBS with diarrhoea as the predominant symptom (IBS-D) and 20 patients had IBS with constipation as the predominant symptom (IBS-C). A total of 27 control subjects (19 females and 8 males with an average age of 53 years) were included. The patients and controls underwent colonoscopy with rectal biopsies. The biopsies were immunostained for total leucocytes, lymphocytes, monocytes, macrophages and mast cells. The mucosal density of these cells was quantified by computer image analysis. The number of intraepithelial leucocytes and the density of the leucocytes in the lamina propria of the IBS patients did not differ from that of the controls. Similarly, there was no difference in the cell density of the mast cells in the lamina propria between the patients and the controls. The numbers of mucosal lymphocytes, macrophages and monocytes were low in the patients and the controls. These findings oppose low-grade inflammation as a pathogenic factor in sporadic IBS. Low-grade inflammation may, however, play an important role in the pathogenesis of a subset of IBS, namely post-infectious IBS (PI-IBS).

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Section: Introductionmentioning

confidence: 99%

Low-grade inflammation in the rectum of patients with sporadic irritable bowel syndrome

Gundersen¹,

Hatlebakk

Hausken

2013

Molecular Medicine Reports

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“…This phenomenon might be interpreted as a defect in the system that regulates testosterone functions. Previous studies have suggested that male sex hormones might protect against IBS [5, 11]. However, the previously reported altered sex hormones were LH and testosterone, not SHBG.…”

Section: Discussionmentioning

confidence: 93%

“…Most explanations of IBS have focused on the concept that women might be more susceptible, in some way, but little attention has been given to the possibility that there may be a protective effect for males [11]. Moreover, there are few reports regarding the role of sex hormones in male patients with IBS.…”

Section: Discussionmentioning

confidence: 99%

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Male Sex Hormones May Influence the Symptoms of Irritable Bowel Syndrome in Young Men

et al. 2008

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Aims: To evaluate the sex hormone status of young male patients with irritable bowel syndrome (IBS) and to investigate whether there were any differences in bowel symptoms related to the hormone levels. Methods: Thirty-eight young male patients with IBS were compared with 20 healthy young men. Details of symptoms were collected by a structured questionnaire. Each subject underwent a blood test and colonoscopy. The blood test included serum testosterone, free testosterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone and luteinizing hormone. Based on the questionnaire, patients were classified as having diarrhea-predominant IBS (IBS-D) or constipation-predominant IBS (IBS-C). Results: Among the 38 patients with IBS, 24 had IBS-D and 14 had IBS-C. The patients had higher levels of testosterone and SHBG than did the controls (p = 0.04 and p = 0.03, respectively). However, there was no significant difference between the IBS-D and IBS-C group with regard to the testosterone and SHBG levels (p > 0.05). There was also no difference in the duration and severity of symptoms between these 2 groups (p > 0.05). Conclusions: Sex hormone status in young men differ from those in older men and may play an important role in the pathophysiology of IBS, regardless of the dominant symptom type.

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“…17 Other studies have found that men with IBS have more nurturing traits and reduction in the male-trait score. 18,19 Psychological Factor and Abuse A history of abuse predisposes patients to IBS. In addition to having a history of abuse of varying types; emotional, sexual, or physical and/or a history of stressful life events, social stress or anxiety and having a maladaptive coping style, affect the severity and clinical course of IBS.…”

Section: Gender and Hormonesmentioning

confidence: 99%

Changing the way we think about irritable bowel syndrome

Coron¹,

Boucard²,

Brelvi³

2006

TMF

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Gender and Irritable Bowel Syndrome

Abstract: Men with irritable bowel syndrome exhibit less male characteristics and it remains to be determined whether this is cause or effect. Whatever the explanation, this study adds another dimension to the role of gender in functional gastrointestinal disorders.

Cited by 33 publications

References 10 publications

Low-grade inflammation in the rectum of patients with sporadic irritable bowel syndrome

Low-grade inflammation in the rectum of patients with sporadic irritable bowel syndrome

Male Sex Hormones May Influence the Symptoms of Irritable Bowel Syndrome in Young Men

Changing the way we think about irritable bowel syndrome

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