Gender and duration of untreated psychosis: a systematic review and meta‐analysis

Cascio, Maria Teresa; Cella, Matteo; Preti, Antonio; Meneghelli, Anna; Cocchi, Angelo

doi:10.1111/j.1751-7893.2012.00351.x

Cited by 70 publications

(55 citation statements)

References 90 publications

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“…Males are reported to have an earlier onset of the disorder, or earlier detection of the symptoms than females (Angermeyer and Kuhn, 1988;Cascio et al, 2012). Earlier onset of schizophrenia in male patients was consistently found in Western countries (Angermeyer and Kuhn, 1988;Faraone et al, 1994;Häfner, 2003;Hambrecht et al, 1992;Szymanski et al, 1995) and in non-Western countries (Gureje, 1991;Hambrecht et al, 1992;Tang et al, 2007;Zhang et al, 2012).…”

Section: Introductionmentioning

confidence: 87%

Sex differences in first-episode psychosis and in people at ultra-high risk

Cocchi¹,

Lora²,

Meneghelli³

et al. 2014

Psychiatry Research

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Section: Introductionmentioning

confidence: 87%

Sex differences in first-episode psychosis and in people at ultra-high risk

Cocchi¹,

Lora²,

Meneghelli³

et al. 2014

Psychiatry Research

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“…For example, men have an earlier age of disease onset, more deficit symptoms and a poorer response to antipsychotic drug treatment (Lindamer et al, 1997). Additionally, sex differences also exist regarding structural and functional brain abnormalities that may underlie the disease pathology (Cascio et al, 2012;Kulkarni et al, 2012;Gonzalez-Rodriguez et al, 2014). However, In the present study, we aimed at further characterizing the effects of prenatal LPS exposure on 5-HT 2A and mGlu2/3 receptor function in the adult rat offspring.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 94%

Maternal lipopolysaccharide treatment differentially affects 5-HT2A and mGlu2/3 receptor function in the adult male and female rat offspring

et al. 2015

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“…For example, reviews and meta-analyses have shown that men have a 1.15-1.4:1 higher incidence of schizophrenia compared to women [16][17][18][19] . Men also have an earlier age of onset compared to women across varying definitions of onset (e.g., first psychotic symptoms, first diagnosis, first hospitalization) [20,21] . Women on average have a better treatment response to antipsychotic medications compared to men, including a more rapid treatment response and lower required dose to achieve a response [12,22] .…”

Section: Introductionmentioning

confidence: 99%

Facial emotion perception in schizophrenia: Does sex matter?

Mote

Kring

2016

WJP

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AIM:To review the literature on sex differences in facial emotion perception (FEP) across the schizophrenia spectrum. METHODS:We conducted a systematic review of empirical articles that were included in five separate meta-analyses of FEP across the schizophrenia spectrum, including meta-analyses that predominantly examined adults with chronic schizophrenia, people with early (onset prior to age 18) or recent-onset (experiencing their first or second psychotic episode or illness duration less than 2 years) schizophrenia, and unaffected first-degree relatives of people with schizophrenia. We also examined articles written in English (from November 2011 through June 2015) that were not included in the aforementioned metaanalyses through a literature search in the PubMed database. All relevant articles were accessed in full text. We examined all studies to determine the sample sizes, diagnostic characteristics, demographic information, methodologies, results, and whether each individual study reported on sex differences. The results from the meta-analyses themselves as well as the individual studies are reported in tables and text. RESULTS:We retrieved 134 articles included in five separate meta-analyses and the PubMed database that examined FEP across the schizophrenia spectrum. Of these articles, 38 examined sex differences in FEP. Thirty of these studies did not find sex differences in FEP in either chronically ill adults with schizophrenia, early-onset or recently diagnosed people with schizophrenia, or first-degree relatives of people with schizophrenia. Of the eight studies that found sex differences in FEP, three found that chronically ill women outperformed men, one study found that girls with early-onset schizophrenia outperformed boys, and two studies found that women (including first-degree relatives, adults with schizophrenia, and the healthy control group) outperformed men on FEP tasks. In total, six of the eight studies that examined sex differences in FEP found that women outperformed men across the SYSTEMATIC REVIEWS Core tip: People with schizophrenia exhibit deficits in facial emotion perception (FEP) compared to healthy controls. These deficits are associated with poorer functioning and more severe symptoms. Although the literature to date suggests that there are few sex differences in FEP in schizophrenia, continued assessment of sex differences in FEP can help researchers and clinicians better understand other sex differences in the disorder and assist in treatment development aimed at improving functioning in people with schizophrenia. This review summarizes and critically evaluates the literature on FEP across the schizophrenia spectrum, focusing on the evidence related to sex differences in FEP.Mote J, Kring AM. Facial emotion perception in schizophrenia: Does sex matter? World J Psychiatr 2016; 6(2): 257-268

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Gender and duration of untreated psychosis: a systematic review and meta‐analysis

Abstract: Earlier age at first contact and larger incidence in males support the existence of specific gender differences in first-episode psychosis; however, these are not associated with DUP length.

Cited by 70 publications

References 90 publications

Sex differences in first-episode psychosis and in people at ultra-high risk

Sex differences in first-episode psychosis and in people at ultra-high risk

Maternal lipopolysaccharide treatment differentially affects 5-HT2A and mGlu2/3 receptor function in the adult male and female rat offspring

Facial emotion perception in schizophrenia: Does sex matter?

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