Gender and Clinical Presentation in Adult Celiac Disease

Ciacci, Carolina; Cirillo, Massimo; Sollazzo, R; Savino, Gustavo; Sabbatini, F; Mazzacca, G

doi:10.3109/00365529509101610

Cited by 158 publications

(95 citation statements)

References 12 publications

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“…The outcomes of long-standing unestablished CD in IDA are that these patients are at risk of preventable problems. The majority of patients (59.5%) were female, a finding comparable to previous studies conducted in the other area of Iran, United States, Europe and the Middle East (14,23) . Such a higher frequency rate of CD amongst women might be attributed to the higher incidence of autoimmune diseases found in the female population.…”

Section: Discussionsupporting

confidence: 76%

The Prevalence of Celiac Disease in Patients With Iron-Deficiency Anemia in Center and South Area of Iran

Baghbanian

Farahat

Vahedian

et al. 2015

Arq. Gastroenterol.

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-Background -Celiac disease is an immune-mediated enteropathy due to a permanent sensitivity to gluten in genetically susceptible people. Iron-deficiency anemia is the most widely experienced anemia in humans. Iron-deficiency anemia additionally is a common extra intestinal manifestation of celiac disease. Objective -To investigate correlation between tTg levels and histological alterations and then to determine the prevalence of celiac disease in Center and South area patients of Iran with iron deficiency anemia. Methods -A total of 402 patients aged 12-78 years who presented with iron-deficiency anemia were included in this study. Hemoglobin, mean corpuscular volume and serum ferritin were determined. Venous blood samples for anti-tissue transglutaminase antibody immunoglobuline A and G were obtained from these patients. Upper gastrointestinal endoscopy was recommended to patients who had positive serology.

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Section: Discussionsupporting

confidence: 76%

The Prevalence of Celiac Disease in Patients With Iron-Deficiency Anemia in Center and South Area of Iran

Baghbanian

Farahat

Vahedian

et al. 2015

Arq. Gastroenterol.

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“…[17][18][19][20] Like other autoimmune diseases, 21 CD is more frequent in females than in males, with a ratio of around 2.5:1. 22 Conversely, T1DM is the only major organ-specific autoimmune disorder that does not show a strong female bias, while it is predominant in males, in particular, in countries with a high incidence. 23 The previous literature reported contradictory results between the sexes for the prevalence of CD in T1DM.…”

Section: Epidemiologymentioning

confidence: 99%

Dietary gluten and the development of celiac disease and type 1 diabetes

Ciacci¹,

Zingone²

2016

NDS

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Abstract:The objective of this study was to perform a review of the present knowledge on the epidemiology and pathogenesis of the association between celiac disease (CD) and type 1 diabetes mellitus (T1DM). Results from this review show that the estimated prevalence rate of CD in T1DM ranges from 4% to 11.5%, which seems higher in children than in adults, while there is no sex predominance in the prevalence of CD in T1DM. On the basis of the previous literature, screening for CD should be considered at diabetes diagnosis in all subjects and again within 2 and 5 years after diagnosis, even in the absence of symptoms. The anti-islet antibodies detection test, instead, is not recommended in CD, just as in the general population, except for CD patients having a relative with T1DM. Both genes and environmental factors seem to play a role in this association. HLADQ2 has been found to be the most frequent allele in the patients with both CD and T1DM, while gluten may be considered the trigger that induces the production of autoantibodies and the development, in genetically predisposed individuals, of both diseases.

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“…CD prevalence rates have also been reported as many as one in 86 men and 52 women based on new serology and genetic testing [6]. CD also appears to be more severe and develops more rapidly in women [7]. While histological, genetic, incidence and prevalence of disease and quality of life research studies are replete in the extant literature, up until recently, neurological and psychological manifestations have also been studied among this cohort in relation to CD.…”

Section: Introductionmentioning

confidence: 99%

Neuropsychiatric Features of Celiac Disease

Arnone

Conti²

2016

IJCD

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Celiac disease (CD) is a T-cell mediated genetically inherited autoimmune disease that has evolved over time. Formerly considered a pediatric disease, the rate of occurrence is now observed in individuals ranging from early childhood to senescence. Strict adherence to a gluten-free diet is the only currently available treatment for CD in order for individuals to avert future complications and malignancies. In the United States, the disease has shown widespread incidence and prevalence rates and affects 1% of the total population in not-at-risk groups. This number translates into 1 out of 133 people in the United States affected, making the disease almost 100 times more common than previously considered. While histological, genetic, incidence and prevalence of disease and quality of life research studies are replete in the extant literature, up until recently, neurological and psychological manifestations have also been studied among this cohort in relation to CD. Neurological conditions such as ataxia and neuropathy in CD have received the most research attention while much less attention has been paid to psychiatric conditions and cognitive functioning. The findings on cognitive functioning in CD have revolved largely around anecdotal reports and small clinical trials totaling approximately 200 patients of varying ages. Studies reporting neuropsychological test data are few and often do not include comprehensive test batteries in which to draw further conclusions on specific cognitive deficits. Larger, well-controlled studies are needed in order to form optimal diagnosis and implementation of specific support measures for individuals living with CD across the lifespan.

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Gender and Clinical Presentation in Adult Celiac Disease

Cited by 158 publications

References 12 publications

The Prevalence of Celiac Disease in Patients With Iron-Deficiency Anemia in Center and South Area of Iran

The Prevalence of Celiac Disease in Patients With Iron-Deficiency Anemia in Center and South Area of Iran

Dietary gluten and the development of celiac disease and type 1 diabetes

Neuropsychiatric Features of Celiac Disease

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