Gender and Bladder Cancer: A Collaborative Review of Etiology, Biology, and Outcomes

Dobruch, Jakub; Daneshmand, Siamak; Fisch, Margit; Lotan, Yair; Noon, Aidan P.; Resnick, Matthew J.; Shariat, Shahrokh F.; Zlotta, Alexandre R.; Boorjian, Stephen A.

doi:10.1016/j.eururo.2015.08.037

Cited by 501 publications

(412 citation statements)

References 93 publications

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“…Previous evidence refers that bladder cancer occurs at any age both in male and female, but the incidence is three to four times greater in male than in female [31, 32]. AR was involved in the biology of various diseases, including bladder cancer [32, 33]. Boorjian et al revealed that AR is inversely correlated with bladder cancer pathologic tumor stage [34].…”

Section: Discussionmentioning

confidence: 99%

“…Statistics have shown that morbidity for bladder cancer is high among the urinary system malignancies [30]. Previous evidence refers that bladder cancer occurs at any age both in male and female, but the incidence is three to four times greater in male than in female [31, 32]. AR was involved in the biology of various diseases, including bladder cancer [32, 33].…”

Section: Discussionmentioning

confidence: 99%

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The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR)

Xiong

Wang

et al. 2017

Cell Physiol Biochem

101

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Backgrounds/Aims: Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is involved in the progression of several tumors. The interaction between lncRNA and miRNA or miRNA’s target genes is reported to play crucial roles in malignancy. In addition, Androgen receptor (AR) is considered to be involved in bladder cancer progression. In this study, we investigated the role of XIST in human bladder cancer and its interaction with miR-124 and AR. Methods: XIST and AR expression was detected in bladder tumor samples and cell lines. Effects of XIST and AR on bladder cancer cells growth, invasion and migration were analyzed. Bioinformatic analysis and luciferase assays were used to identify the interaction among XIST, AR and miR-124. The correlations of miR-124 with XIST and AR in bladder cancer samples were statistically analyzed. Results: XIST and AR were upregulated in bladder cancer tissues and positively correlated. Higher XIST and AR expression were related to poorer TNM stage of bladder cancer. XIST knockdown reduced bladder cancer cells’ proliferation, invasion and migration. While this inhibitory effect could be partially restored by AR overexpression. XIST inhibited miR-124 expression by directly targeting. Moreover, miR-124 could bind to the 3’UTR of AR to regulate its expression. MiR-124 inhibition partially restored the XIST knockdown-induced reduction of AR, c-myc, p27, MMP13 and MMP9 expression. In bladder cancer tissues, miR-124 level was inversely correlated with the expression of XIST and AR, respectively. Conclusion: These findings indicated that XIST might be an oncogenic lncRNA that promoted the bladder cancer growth, invasion and migration via miR-124 dependent AR regulation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR)

Xiong

Wang

et al. 2017

Cell Physiol Biochem

101

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“…Bladder cancer has been known as one of the most frequent urological malignancies with a high incidence and mortality rate (1,2). Although recent advances in treatment have led to increased survival rates for patients with bladder cancer, the incidence and mortality rates are still increasing (3,4).…”

Section: Introductionmentioning

confidence: 99%

Induction of apoptosis by ethanol extract of <i>Citrus unshiu</i> Markovich peel in human bladder cancer T24 cells through ROS-mediated inactivation of the PI3K/Akt pathway

Ahn

Choi

Kwon

et al. 2017

BST

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“…Interestingly, it has been reported that the incidence of bladder cancer is 3-4 times greater in men than in women (5). Lifestyle or environmental factors, such as cigarette smoke and industrial chemicals, are believed to be responsible for the gender-specific disparity in bladder cancer morbidity and aggressiveness (6).…”

Section: Introductionmentioning

confidence: 99%

Expression and clinical significance of androgen receptor in bladder cancer: A meta-analysis

Chen

Liu

et al. 2017

Molecular and Clinical Oncology

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Abstract. Emerging evidence has demonstrated that androgen receptor (AR) is a promising therapeutic target for bladder cancer. However, the relationship between AR expression and its clinical significance remains controversial. The present in-depth meta-analysis aimed to investigate the correlation between AR expression and clinicopathological features, as well as prognostic value in bladder cancer. A systematic search was performed from PubMed, Web of Knowledge, Embase and the Cochrane Central Search Library by January 2017. The correlation between AR expression and tumor stage, tumor grade, recurrence free survival and progression free survival for patients with bladder cancer was evaluated. A total of 12 relevant studies with 1,652 patient samples were included. AR expression positively correlated with low tumor grade [odds ratio (OR), 1.95; 95% confidence interval (CI), 1.36-2.81], low tumor stage (OR, 2.06; 95% CI, 1.02-4.16) and low recurrence rate [hazard ratio (HR), 0.48; 95% CI, 0.31-0.75] in Caucasian patients. While, its expression had no significant impact on cancer susceptibility (OR, 1.62; 95% CI, P= 0.44) and progression-free survival (HR, 1.20; 95% CI, P=0.77). The present meta-analysis indicated that AR expression correlates with tumor grade, clinical stage and recurrence rates in the specified population and classification system.Further studies are required to determine the precise role of AR in bladder cancer.

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Gender and Bladder Cancer: A Collaborative Review of Etiology, Biology, and Outcomes

Cited by 501 publications

References 93 publications

The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR)

The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR)

Induction of apoptosis by ethanol extract of <i>Citrus unshiu</i> Markovich peel in human bladder cancer T24 cells through ROS-mediated inactivation of the PI3K/Akt pathway

Expression and clinical significance of androgen receptor in bladder cancer: A meta-analysis

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