Gender, age, and body weight are the major predictive factors for bone mineral density in Crohn's disease: a case-control cross-sectional study of 113 patients

Abstract

Gender, age, and body weight are the major determinants of bone mineral density in patients with Crohn's disease. As in healthy individuals, the combined effect of these factors account for up to 50% of the variability in bone mineral density.

Chronobiological aspects of adult-onset Crohn disease

“…In contrast, a study of patients in Italy [26] does not mention a relationship of age to BMD, but found the femur T-score to be significantly inversely related to disease duration. No predictive value for BMD was ascribed to disease duration by the Danish [23] and Canadian [25] groups mentioned above. The latter group adjusted disease duration for age.…”

“…However, in Canada relapses of Crohn disease peaked in autumn and winter, with a summer trough [22]. Researchers in Denmark [23], southern Norway [24] and Toronto, Canada [25] have recently reported a negative association of bone mineral density with age, at least in some locations of DEXA measurements. This is in partial agreement with the nonsignificant decrease of T-score with age in patients with active disease in our study, but not quite with the borderline significant increase of T-score in patients with inactive disease up to age 35 followed by its borderline significant decrease thereafter.…”

Fracture-Associated Hospitalizations in Patients with Inflammatory Bowel Disease

“…Although there is some information supporting the relationship between steroid use and osteoporosis [6], the data regarding the translation of this into elevated fracture risk in the IBD population are unclear, as are data regarding the influence of disease duration or extent. Card et al found a significant association between corticosteroid use and fractures in IBD patients [13,28], but other studies failed to support this association [14,15,18,29] and found equal prevalence and cumulative dose of steroid use between IBD patients who developed fractures and controls. Similarly, disease duration or extent have not been consistently associated with fractures in IBD patients as a whole, but may play a role in select subgroups [7,18].…”

“…Card et al found a significant association between corticosteroid use and fractures in IBD patients [13,28], but other studies failed to support this association [14,15,18,29] and found equal prevalence and cumulative dose of steroid use between IBD patients who developed fractures and controls. Similarly, disease duration or extent have not been consistently associated with fractures in IBD patients as a whole, but may play a role in select subgroups [7,18]. Another limitation of our study includes restriction of our analysis to patients and controls with fractures requiring hospitalization.…”

“…Some studies identified a 30-60% increase in the incidence of fractures [12,13,17], while others found no difference in fracture rate between IBD and non-IBD cohorts [14][15][16]. The influence of disease and treatment factors on fracture risk has also yielded contrasting results [7,13,[16][17][18][19]. In addition, none of these studies compared characteristics of IBD patients with fractures with those of non-IBD fracture patients.…”