Gen supresor de tumores p53 en neoplasias digestivas

Roa, Juan Carlos; E, Iván Roa; O, Juan C Araya; H, Miguel A Villaseca; A, Angélica Melo; S, Luis Burgos

doi:10.4067/s0034-98872000001100013

Cited by 2 publications

(4 citation statements)

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“…Current evidence indicates that alterations of P53 at the gene level occur late in the pathogenesis of cancer and that the most frequent mechanism of inactivation corresponds to mutation of one allele followed by the deletion of the remaining allele (Gallego et al, 2010). As a result, TP53 gene alterations are useful signals of many types of cancer in humans (Roa et al, 2002). Likewise, in a recent study using exome sequencing in twelve types of cancer, P53 was the most frequently mutated gene in most cancer types studied (Duffy et al, 2017).…”

Section: P53 Variations Databases: Uniprotmentioning

confidence: 97%

Tp53 Pathogenic Variants Related to Cancer

Rosero

Mejia

Corredor

2019

BAG

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TP53 or P53 is a tumor suppressor gene known as the “genome guardian”, responsible for inducing cell response to DNA damage, by stopping the cell cycle in case of mutation, activating DNA repair enzymes, initiating senescence and activation of apoptosis. Mutations in the gene sequence can cause non-synonymous mutations or errors in the reading frame by insertion, deletion or displacement of nucleotides: e.g., c.358A>G mutation in exon 4 and variants located in exons 9 and 10 of the TD domain. Therefore, in this review, we will see that changes in the reading frame, including the loss of one or two base pairs could prevent accurate transcription or changes in the structure and function of the protein, and could completely impair reparation function. These changes promote self-sufficiency in growth signaling, insensitivity to anti-growth signals, and evasion of apoptosis, resulting in limitless replication and induction of metastatic angiogenesis, generating as a consequence the proliferation of tumor, neoplastic, and lymphoid cells. Taking into account the importance of TP53 in the regulation of the cell cycle, the objective of this review is to update information related to the role of this gene in the development of cancer and the description of genetic variations. Key words: Neoplasms, nuclear phosphoprotein p53, Tumor Suppressor, mutation, Clinvar, Uniprot

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Section: P53 Variations Databases: Uniprotmentioning

confidence: 97%

Tp53 Pathogenic Variants Related to Cancer

Rosero

Mejia

Corredor

2019

BAG

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Section: P53 Variations Databases: Uniprotmentioning

confidence: 98%

“…Cancer is the result of the accumulation of multiple alterations in the genes that regulate cell growth and are considered critical for the progressive transformation of non-cancerous cells to malignant cells (Sánchez, 2006;Pierce, 2009;Herrera et al, 2010;Risueño, 2012). Some alterations include point mutations, chromosome disruption, repair interruption, epigenetic alterations, and oncogene rearrangements as well as loss or alteration in the function of tumor suppressor genes (Roa et al, 2000;Pierce, 2009). Among the tumor suppressor genes most commonly altered in various cancers, the tumor suppressor gene TP53 is notable.…”

Section: T P 5 3 I N T H E D E V E L O P M E N T O F C a N C E Rmentioning

confidence: 99%

“…A homozygous TP53 deletion is a rare event, possibly due to its close relationship with genes essential for the cell (e.g., POLR2A) (Donehower et al, 2019). As a result, TP53 gene alterations are useful signals of many types of cancer in humans (Roa et al, 2002). Likewise, in a recent study using exome sequencing in twelve types of cancer, TP53 was the most frequently mutated gene in most cancer types studied (Duffy et al, 2017).…”

Section: A R I a T I O N Smentioning

confidence: 99%

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CONGRESO ALAG 2019 (6 AL 9 DE OCTUBRE. MENDOZA, ARGENTINA). RESÚMENES OMITIDOS y MODIFICACIONES SOLICITADAS POR LOS AUTORES EN RESÚMENES PUBLICADOS

2019

BAG

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Spike fertility index (SF) has been well established as an ecophysiological trait related to grain number per unit area and a promising selection target in wheat breeding programs.Scarce information on the molecular basis of SF is available thus far. In this study, a preliminary molecular marker analysis was carried out in a RIL population derived from the cross between two Argentinean cultivars with contrasting SF to identify candidate genomic regions associated with SF. Twenty-four microsatellites and two functional markers that had been found to co-segregate with SF in a bulked-segregant analysis of the F 3 generation of the population were analyzed. Phenotypic data were collected from three field experiments carried out during 2013, 2014 and 2015 growing seasons at Balcarce, Argentina. Two genomic regions associated with SF in chromosomes 5BS and 7AS were detected, which merit further investigation.

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Gen supresor de tumores p53 en neoplasias digestivas

Cited by 2 publications

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Tp53 Pathogenic Variants Related to Cancer

Tp53 Pathogenic Variants Related to Cancer

CONGRESO ALAG 2019 (6 AL 9 DE OCTUBRE. MENDOZA, ARGENTINA). RESÚMENES OMITIDOS y MODIFICACIONES SOLICITADAS POR LOS AUTORES EN RESÚMENES PUBLICADOS

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