Gen Regulasi Tanaman Lokal Indonesia: Imunomodulator Covid-19

Aziz, Isna Rasdianah; Armita, Devi; Hajrah, Hajrah; Makmur, Kurnia

doi:10.24252/teknosains.v14i2.15901

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Tahapan pelaksanaan pengabdian disajikan bpada bagan berikut: Berdasarkan penelitian, beberapa tanaman obat memiliki kandungan senyawa imunostimulan yaitu senyawa yang dapat meningkatkan respon imun terhadap infeksi. Tanaman seperti jahe, kunyit, temulawak, kencur, sereh, meniran, kelor, sambiloto, bawang putih, dan salam berdasarkan hasil uji pre klinis dapat berfungsi sebagai imunostim ula n (Lestari et al, 2019); (Aziz et al, 2020).…”

Section: Metode Penelitianunclassified

Edukasi Potensi Toga Sebagai Imunostimulan Untuk Pencegahan Covid-19

Indriasari,

Cahyani

2022

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Kondisi pandemi Covid-19 ini mendorong masyarakat melakukan berbagai upaya untuk mencegah infeksi maupun meminimalkan tingkat keparahan gejala jika terinfeksi virus corona. Salah satu upaya yang dapat dilakukan dalam penanganan dan pencegahan yaitu dengan meningkatkan sistem imun dengan memanfaatkan tanaman berkhasiat obat yang mengandung kurkuminoid, zingiberol, alkaloida, minyak atsiri, dan andografolida. Beberapa jenis tanaman obat yang memiliki potensi sebagai imunostimulan yang mampu meningkatkan respon imun terhadap infeksi, saat ini masih belum banyak diketahui oleh masyarakat luas, termasuk Ibu-ibu PKK di lingkungan RW 01 Kelurahan Karangrejo yang telah melaksanakan program TOGA di sekitar rumah masing-masing. Edukasi melalui penyuluhan tentang obat tradisional, sistem imun, dan potensi berbagai jenis TOGA sebagai imunostimulan diharapkan dapat meningkatkan peran aktif Ibu-ibu PKK di lingkungan RW 01 Kelurahan Karangrejo dalam upaya peningkatan sistem imun dan kualitas kesehatan keluarga di masa pandemi. Peningkatan kualitas ini diiringi dengan peningkatan ilmu pengetahuan umum tentang obat tradisional dan imunitas sebesar 25% dan peningkatan pengetahuan TOGA yang berpotensi sebagai imunostimulan sebesar 16,36%.

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Section: Metode Penelitianunclassified

Edukasi Potensi Toga Sebagai Imunostimulan Untuk Pencegahan Covid-19

Indriasari,

Cahyani

2022

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“…Previous research showed that experts are developing several local Indonesian plants to prevent SARS-CoV-2 infection (Aziz et al, 2020). Previous research results have shown significantly that certain plants increase the body's immunity by increasing the production of competent immune cells.…”

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confidence: 99%

A Network Pharmacology of Brotowali (Tinospora cordifolia) on Immunity Cases

Susanto,

Jamil,

Muchlisin

et al. 2023

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COVID-19 is a disease outbreak related to the human immune system. The process of spreading very quickly makes this outbreak a dangerous pandemic. COVID-19 cases in 2020 in Indonesia, positive cases were reaching 1,089,308 people with a death rate of 20,277 people as of 2 February 2021. Efforts are being made to reduce and prevent virus transmission by boosting the immune system using an immunomodulator. Based on the literature studies that have been conducted, several Indonesian local plants have potential as immunomodulator. The in silico test was carried out because the computer simulation method has scientific validity, is relatively new, and has a high level of accuracy. This study aims to determine the protein network associated with the body's immune system, which is activated due to the administration of Brotowali (Tinospora Cordifolia). The research method used is exploratory descriptive with in silico analysis using a computational model with online databases, including KNApSAck, Dr. Duke, Pubchem, SwissADME, SwissTargetPrediction, Venny, StringDB, and KEGG. Based on the results of pharmacological network analysis, T. Cordifolia contains 33 secondary metabolites, 25 of which have high bioavailability. Proteins associated with T. cordifolia contain 640 compounds, and those related to immunomodulators contain 1380 proteins. The intersection results obtained 191 proteins predicted to interact with T. cordifolia and are related to immunomodulators. Based on KEGG Pathway analysis, there are five critical pathways in the immunomodulatory system, namely Th17 cell differentiation, IL-17 signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, and TNF signaling pathway. 1-hydroxy-2-methyl-anthraquinone can be an immunomodulator because it interacts with five critical pathways in the immunomodulator system.

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