GEMS: Underwater spectrometer for long-term radioactivity measurements

Sartini, Ludovica; Simeone, F.; Pani, P.; Bue, Nadia Lo; Marinaro, G.; Grubich, A. O.; Лобко, А. С.; Etiope, Giuseppe; Capone, A.; Favali, P.; Gasparoni, F.; Bruni, F.

doi:10.1016/j.nima.2010.06.248

Cited by 216 publications

(8 citation statements)

References 9 publications

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“…The dosimetric system was calibrated under reference conditions according to the International Atomic Energy Agency Technical Reports Series No. 398 “Absorbed Dose Determination in External Beam Radiotherapy” [74].…”

Section: Methodsmentioning

confidence: 99%

Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line

Cammarata

Torrisi

Forte

et al. 2019

IJMS

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Glioblastoma Multiforme (GBM) is the most common of malignant gliomas in adults with an exiguous life expectancy. Standard treatments are not curative and the resistance to both chemotherapy and conventional radiotherapy (RT) plans is the main cause of GBM care failures. Proton therapy (PT) shows a ballistic precision and a higher dose conformity than conventional RT. In this study we investigated the radiosensitive effects of a new targeted compound, SRC inhibitor, named Si306, in combination with PT on the U87 glioblastoma cell line. Clonogenic survival assay, dose modifying factor calculation and linear-quadratic model were performed to evaluate radiosensitizing effects mediated by combination of the Si306 with PT. Gene expression profiling by microarray was also conducted after PT treatments alone or combined, to identify gene signatures as biomarkers of response to treatments. Our results indicate that the Si306 compound exhibits a radiosensitizing action on the U87 cells causing a synergic cytotoxic effect with PT. In addition, microarray data confirm the SRC role as the main Si306 target and highlights new genes modulated by the combined action of Si306 and PT. We suggest, the Si306 as a new candidate to treat GBM in combination with PT, overcoming resistance to conventional treatments.

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Section: Methodsmentioning

confidence: 99%

Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line

Cammarata

Torrisi

Forte

et al. 2019

IJMS

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show abstract

“…To obtain timely radiation data for emergency responses, as in the case of the Fukushima Daiichi nuclear accident [ 3 ], on-site radionuclide identification techniques for underwater environments have been developed. Most techniques focused on gamma-ray spectrometry based on NaI(Tl) crystal as a high-energy gamma-ray wavelength shifter [ 4 , 5 , 6 , 7 , 8 ]. In addition to NaI(Tl) crystals, other materials such as LaBr 3 (Ce) [ 9 ], Gd 3 Al 2 Ga 3 O 12 (Ce) [ 10 ], and CeBr 3 [ 11 ] have been tested to improve optical properties such as energy resolution, light yield, and/or stability.…”

Section: Introductionmentioning

confidence: 99%

Gamma-Ray Sensor Using YAlO3(Ce) Single Crystal and CNT/PEEK with High Sensitivity and Stability under Harsh Underwater Conditions

Lee

Kim

2021

Sensors

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A new gamma-ray sensor, which could be employed in harsh underwater conditions, was developed using YAlO3(Ce) single crystal and carbon nanotube reinforced polyetheretherketone (CNT/PEEK). The sensor is compact, highly sensitive and stable, by providing real-time gross counts and an accumulated spectrum for fresh, saline, or contaminated water conditions. The sensor was tested in a water tank for quantification of the limit of detections. The Φ51 × 51 mm2 YAlO3(Ce) crystal exhibits a nearly perfect proportionality with a correlation of over 0.999 in terms of light yield per energy and possesses a high energy resolution. The chemically stable CNT/PEEK window material further enhances the detection efficiency by minimizing the background counts from penetrating gamma-rays. Data timeliness was obtained for regulation-based minimum detectable activity targets within 300 s. For a source-detector distance of up to 300 mm in water, the gross counts demonstrate the existence of radionuclides (Cs-137 and Co-60), owing to their higher efficiency (max. ~15 times) than those of the photopeak counts. Such differences between efficiency values are more likely in water than in air because of the high density of water, resulting in an increased build-up of scattered photons. The proposed sensor is suitable for autonomous underwater systems.

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“…Zařízení potřebná k zásobování přístroje elektrickou energií a k vyhodnocení odezvy detektoru jsou umístěna na voru plujícím na vodní hladině. Podle požadované citlivosti přístrojů jsou voleny různé varianty detektorů, typem detektoru je zase podmíněna volba elektrického napájení [10][11][12][13].…”

Section: Monitorovací Systém Sagma a Síť Scomo V Kontextu Havarijního Monitorováníunclassified

Systém pro kontinuální monitorování radioaktivní kontaminace povrchových vod

Fejgl¹,

Hýža²,

Hůlka³

2019

VTEI

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GEMS: Underwater spectrometer for long-term radioactivity measurements

Cited by 216 publications

References 9 publications

Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line

Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line

Gamma-Ray Sensor Using YAlO3(Ce) Single Crystal and CNT/PEEK with High Sensitivity and Stability under Harsh Underwater Conditions

Systém pro kontinuální monitorování radioaktivní kontaminace povrchových vod

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