Gemeinsame Studie zur Erstellung von Richtwerten für klinisch-chemische Kenngrößen im Kindesalter

Witt, I.; Trendelenburg, Chr.

doi:10.1515/cclm.1982.20.4.235

Cited by 20 publications

(8 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For all other probands blood samples were taken after written consent was obtained from their parents, who were informed as to the purpose of the tests. (9), which permit the assembly of a reliable reference sample at a justifiable expense. Only those neonates with a birthweight between 2500 and 4000 g and a full term gestation time between 37 and 40 weeks were admitted to the 5-day-old age group.…”

Section: Methodsmentioning

confidence: 99%

Establishment of Reference Ranges for Ferritin in Neonates, Infants, Children and Adolescents

Wiedemann

Jonetz-Mentzel²

1993

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

Ferritin was determined in the sera of 631 healthy neonates, infants, children and adolescents (age range 5 days to 18 years), using the IMx from Abbott Laboratories. The applied test was a microparticle enzyme immunoassay (MEIA). The proband collective was divided into 9 age groups, and each group into males and females. In accordance with the recommendations of the International Federation of Clinical Chemistry, the 95% scatter range was taken as the reference range. Only a few reference groups showed a normal Gaussian distribution. In addition to the 50th percentile, the 2.5th and 97.5th percentile were calculated for all reference groups, and the minimal and maximal values were also reported. Significantly different reference ranges were found for males and females in the age group 16 -18 years. The U-test of Mann & Whitney was used to test for significant differences between individual reference groups. Groups showing no significant differences were combined, and the corresponding reference ranges for serum ferritin were then calculated.

show abstract

Section: Methodsmentioning

confidence: 99%

Establishment of Reference Ranges for Ferritin in Neonates, Infants, Children and Adolescents

Wiedemann

Jonetz-Mentzel²

1993

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

show abstract

“…The age composition of the proband collective is summarized in table 1. Individuals were included or excluded according to the exclusion criteria of Witt & Trendelenburg (6), which permit the assembly of a reliable random reference sample at a justifiable expense. Only those neonates with a birth weight between 2500 and 4000 g and a full term gestation time between 37 and 40 weeks were admitted to the 5-day-old age group.…”

Section: Methodsmentioning

confidence: 99%

Establishment of Reference Ranges for Thyrotropin, Triiodothyronine, Thyroxine and Free Thyroxine in Neonates, Infants, Children and Adolescents

Wiedemann

Jonetz-Mentzel²,

Panse³

1993

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

Summary: Thyrotropin, triiodothyronine, thyroxine and free thyroxine were determined in the sera of 714 euthyreotic neonates, infants, children and adolescents (age range 5 days to 18 years), using the IMx from Abbott Laboratories. Thyrotropin, triiodothyronine and free thyroxine were determined with microparticle enzyme immunoassays (MEIA). Thyroxine was determined with a fluorescence polarization immunoassay (FPIA). The proband collective was divided into 9 age groups, and each age group into males and females. In accordance with the recommendations of the International Federation of Clinical Chemistry, the 95% scatter range was taken as the reference range. In the different age groups, the ranges of some hormones showed significant differences between males and females. When no significant difference existed between the sexes, the results for males and females were evaluated statistically as a single group. Only a few reference groups showed normal Gaussian distributions. Therefore, in addition to the 50th percentile, the 2.5th and 97.5th percentiles were also calculated for all reference groups. Minimal and maximal values were also determined. The U-test of Mann & Whitiiey was used to test for significant differences between individual reference groups, and groups showing no significant differences were combined. The corresponding references ranges were then calculated.

show abstract

“…(1) The methods used for enzyme measurements are often not comparable with today's stan dardised assays [24,25]. (2) Most investiga tions pooled the results of very imprecise time intervals, as a rule the first week of life, so that the important time interval of the first hours of life could not be assessed [8,26]. (3) Many studies included only small numbers of test subjects (e.g., 22-33 pro bands), so that any statistical analysis is questionable [9,27],…”

mentioning

confidence: 99%

Serum Enzyme Activities in Full-Term Asphyxiated and Healthy Newborns: Enzyme Kinetics during the First 144 Hours of Life

Lackmann¹,

Töllner²,

Mader³

1993

Enzyme Protein

View full text Add to dashboard Cite

Little is known about the kinetics of most serum enzymes during the first hours of life, and even less about the effect on such enzyme activities of perinatal hypoxia-ischaemia. It was the aim of the present study to evaluate the serum kinetics of seven differently located cell enzymes in healthy and asphyxiated newborns during the 1st week of life. The serum activities of cytoplasmic and mitochondrial [aspartate aminotransferase (ASAT), creatine kinase (CK), glutamate dehydrogenase (GLDH), lactate dehydrogenase (LDH), and hydroxybutyrate dehydrogenase (HBDH)] and membrane-bound (γ-glutamyltransferase and leucine arylaminidase) enzymes were prospectively measured in full-term asphyxiated (n = 49) and healthy (n = 87) newborns during the first 144 h of life. The blood samples were taken serially at five fixed times; 0 (cord), 12,24,72, and 144 h postpartum. The asphyxiated newborns had significantly increased serum activities of ASAT, LDH, and HBDH up to 72 h postpartum, whereas healthy newborns showed higher CK and GLDH activities. Only the activities of ASAT, LDH, and HBDH seemed to depend on the oxygen supply of the fetus or newborn. If other causes of increased serum enzyme activities, e.g. liver diseases, haemolytic disorders, tumours, or inborn errors of metabolism, are excluded, elevated serum activities of ASAT, LDH, and HBDH should draw one’s attention to a perinatal hypoxic-ischaemic insult of the newborn.

show abstract

Gemeinsame Studie zur Erstellung von Richtwerten für klinisch-chemische Kenngrößen im Kindesalter

Cited by 20 publications

References 3 publications

Establishment of Reference Ranges for Ferritin in Neonates, Infants, Children and Adolescents

Establishment of Reference Ranges for Ferritin in Neonates, Infants, Children and Adolescents

Establishment of Reference Ranges for Thyrotropin, Triiodothyronine, Thyroxine and Free Thyroxine in Neonates, Infants, Children and Adolescents

Serum Enzyme Activities in Full-Term Asphyxiated and Healthy Newborns: Enzyme Kinetics during the First 144 Hours of Life

Contact Info

Product

Resources

About